Others

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

• HY-Y0873

  PEG300	25322-68-3
  PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1][2].

  

• HY-17031

  SBE-β-CD	182410-00-0
  SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents[1].

  

• HY-Y1888

  Corn oil	8001-30-7
  Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules.

  

• HY-Y1891

  Tween 80	9005-65-6
  Tween 80 (Polysorbate 80), a surfactant, has been widely used as a solvent for pharmacological experiments. Tween 80 can also reduce bacterial attachment and inhibit biofilm formation.

  

• HY-D0940

  H2DCFDA	4091-99-0
  H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm)[1].

  

• HY-Y0873A

  PEG400
  PEG400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances. PEG400 is widely used in a variety of pharmaceutical formulations.

  

• HY-Y1893

  Polyethylene glycol 12-hydroxystearate	61909-81-7
  Polyethylene glycol 12-hydroxystearate, a Macrogol 15 hydroxy stearate, is a permeability enhancer[1].

  

• HY-15979A

  H-89 dihydrochloride	130964-39-5	99.34%
  H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.

  

• HY-12270

  T-5224	530141-72-1	99.59%
  T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription[1][2].

  

• HY-Y1890

  Cremophor EL	61791-12-6	99.52%
  Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of drugs[1].

  

• HY-12222

  Obeticholic acid	459789-99-2
  Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

  

• HY-15534

  JC-1	3520-43-2
  JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585nm, Em=590nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=514nm, em=529nm)[1].

  

• HY-D0718

  Nile Red	7385-67-3	98.15%
  Nile red (Nile blue oxazone) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm[1].

  

• HY-D0938

  CFDA-SE	150347-59-4
  CFSE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFSE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus[1]. CFSE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488nm, and can be used to detect the proliferation of cells[1].

  

• HY-D0843

  N-Ethylmaleimide	128-53-0
  N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides[1][2][3].

  

• HY-15917

  DL-dithiothreitol	3483-12-3
  DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized.

  

• HY-66019

  FITC	3326-32-7
  FITC (Fluorescein 5-isothiocyanate) is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu2+-sensitive fluorescence dye[1][2].

  

• HY-D0815

  Propidium Iodide	25535-16-4
  Propidium Iodide is a red-fluorescent dye that can be used to stain cells.

  

• HY-Y1903

  Phosal 50 PG	774594-96-6
  Phosal 50 PG is a cosolvent (standardised phosphatidylcholine concentrate). Phosal 50 PG as a carrier for lipophilic compounds, can improve the absorption, efficacy and therapeutic index of the active ingredient[1].

  

• HY-Y0703

  Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)	9004-32-4
  Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

  

• HY-108331

  3-TYP	120241-79-4	99.93%
  3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).

  

• HY-138489

  Lats-IN-1	1424635-83-5
  Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].

  

• HY-12591B

  D-Luciferin potassium	115144-35-9
  D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and drug screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

  

• HY-15924

  Thiazolyl Blue	298-93-1
  Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis[1].

  

• HY-15921

  IPTG	367-93-1
  IPTG is a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon, and it is therefore used to induce protein expression where the gene is under the control of the lac operator.

  

• HY-B0496

  PMSF	329-98-6
  PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.

  

• HY-W009724

  2-Aminoethyl diphenylborinate	524-95-8	98.36%
  2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].

  

• HY-12451

  FICZ	172922-91-7
  FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.

  

• HY-128868A

  FITC-Dextran (MW 4000)	60842-46-8
  FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption[1][2][3].

  

• HY-15680

  O-Propargyl-Puromycin	1416561-90-4	98.68%
  O-Propargyl-Puromycin, an alkyne analog of puromycin, is a potent protein synthesis inhibitor.

  

• HY-P0319A

  3X FLAG peptide TFA		99.79%
  3X FLAG peptide TFA is a synthetic peptide with a 3-time repeated DYKXXD motif[1].

  

• HY-D0814

  DAPI dihydrochloride	28718-90-3
  DAPI dihydrochloride (4',6-diamidino-2-phenylindole) is a fluorescent stain by binding in the minor grove of A-T rich sequences of DNA.

  

• HY-112210

  Shield-1	914805-33-7	99.46%
  Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3].

  

• HY-128868

  FITC-Dextran (MW 10000)	60842-46-8
  FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption[1][2][3].

  

• HY-W011500

  TCEP hydrochloride	51805-45-9
  TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry[1][2][3][4].

  

• HY-B2247

  PLGA (50:50)	34346-01-5
  PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.

  

• HY-112758

  DLin-KC2-DMA	1190197-97-7
  DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies[1][2].

  

• HY-D0079

  Dihydroethidium	104821-25-2
  Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red (Ex/Em=518/616 nm).

  

• HY-103087

  FIN56	1083162-61-1	99.27%
  FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase[1].

  

• HY-12591A

  D-Luciferin	2591-17-5	99.87%
  D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and drug screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

  

• HY-D0083

  DiI	41085-99-8
  DiI is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins[2].

  

• HY-101896

  Fluo-4 AM	273221-67-3
  Fluo-4 AM is a cell-permeable Ca2+ indicator[1].

  

• HY-W010918

  Adenosine 5'-diphosphate	58-64-0
  Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

  

• HY-D0218

  Thioflavin T	2390-54-7
  Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections.

  

• HY-D0985A

  TMRE	115532-52-0
  Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1].

  

• HY-D0711

  Indocyanine green	3599-32-4
  Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography.

  

• HY-12821

  AEBSF hydrochloride	30827-99-7
  AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

  

• HY-D0842

  Bovine Serum Albumin	9048-46-8
  Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications.

  

• HY-W090090

  BODIPY 493/503	121207-31-6
  BODIPY 493/503 (Pyrromethene 546) is a fluorescent neutral lipid dye (Ex/Em: 493/503 nm). BODIPY 493/503 can facilitate quantification of neutral lipid content by flow cytometry and observation of lipid droplets (LDs) by microscopy[1].

  

• HY-13813

  Blebbistatin	674289-55-5
  Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration[1][2].

  

• HY-12591

  D-Luciferin sodium	103404-75-7
  D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and drug screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP[1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

  

• HY-116215

  2-NBDG	186689-07-6
  2-NBDG is a fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues. It is also used as a topical contrast reagent for the detection of neoplasia. 2-NBDG can be used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry. The probe can be excited by the Argon laser at 488 nm to give the environment-sensitive fluorescence. It has lower photostability than the rhodamine-based fluorescent probes.

  

• HY-15559

  Hoechst 33342	23491-52-3
  Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA.

  

• HY-114158

  Pronase E (Activity ≥ 7000 U/mg)	9036-06-0
  Pronase E (Activity ≥ 7000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids[1].

  

• HY-B0332

  Menadione	58-27-5	99.88%
  Menadione, a naphthoquinone, can be converted to active vitamin K2 in vivo.

  

• HY-13248

  AR-C155858	496791-37-8	99.62%
  AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.

  

• HY-111444

  Auxinole	86445-22-9	99.89%
  Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.

  

• HY-101879

  Acridine Orange hydrochloride	65-61-2	99.86%
  Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm)[1][2][3].

  

• HY-16714

  4-Azido-L-phenylalanine	33173-53-4	99.84%
  4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

  

• HY-100168

  BAPTA	85233-19-8
  BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2].

  

• HY-P0319

  3X FLAG peptide	402750-12-3	98.32%
  3X FLAG Peptide is a synthetic peptide with a 3-time repeated DYKXXD motif.

  

• HY-107910

  Hyaluronidase	37326-33-3
  Hyaluronidase (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is a naturally occurring enzyme that depolymerizes hyaluronic acid by cleavage of glycosidic bonds and has been utilized in ophthalmic surgery[1][2].

  

• HY-B1102

  Evans Blue	314-13-6
  Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).

  

• HY-111382

  Diphenylterazine	344940-63-2
  Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background, leading to excellent signal-to-background ratios[1].

  

• HY-15559A

  Hoechst 33342 trihydrochloride	875756-97-1	99.81%
  Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain.

  

• HY-A0181

  Adenosine monophosphate	61-19-8
  Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.

  

• HY-100947

  VH-298	2097381-85-4	99.83%
  VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.

  

• HY-D0903

  1,8-Diazafluoren-9-one	54078-29-4
  1,8-Diazafluoren-9-one (DFO) is a chemical that is used to find fingerprints on porous surfaces.

  

• HY-W013636

  2-Ketoglutaric acid	328-50-7
  2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[1].

  

• HY-D0831

  WST-8	193149-74-5
  WST-8 is a water-soluble tetrazolium dye, WST-8 enhances sensitivity of the WST-8-based assay over the conventional MTS-based assay.

  

• HY-125658

  Biotinyl tyramide	41994-02-9	99.73%
  Biotinyl tyramide is a biotin derivative used for tyramide signal amplification (TSA), as a reagent to amplify both immunohistochemical signals and in situ hybridization protocols[1][2][3][4].

  

• HY-18569

  3-Indoleacetic acid	87-51-4	99.97%
  3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

  

• HY-119706

  Barbadin	356568-70-2
  Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis[1][2].

  

• HY-112641A

  AkaLumine hydrochloride	2558205-28-8
  AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant Fluc protein.

  

• HY-15915

  DTNB	69-78-3
  DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups[1].

  

• HY-111534

  SBI-115	882366-16-7	99.57%
  SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1].

  

• HY-D0821

  CY5	146368-11-8	99.66%
  CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

  

• HY-D0040

  Calcein	1461-15-0
  Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.

  

• HY-D0819

  CY5-SE	146368-14-1
  Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

  

• HY-D0972

  Thioflavine S	1326-12-1
  Thioflavine S is a fluorescent histochemical marker of dense core senile plaques.

  

• HY-D0086

  DIDS sodium salt	67483-13-0
  DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.

  

• HY-145405

  C12-200	1220890-25-4
  C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids. C12-200 is commonly used for mRNA delivery[1][2].

  

• HY-D0969

  3,3'-Dioctadecyloxacarbocyanine perchlorate	34215-57-1
  DiO is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins[2].

  

• HY-Y1892

  Gelucire 44/14	121548-04-7
  Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery.

  

• HY-16671

  CFTR(inh)-172	307510-92-5	99.25%
  CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.

  

• HY-B1247

  Protoporphyrin IX	553-12-8
  Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.

  

• HY-D0802

  Biotin NHS	35013-72-0
  Biotin NHS is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides.

  

• HY-114158A

  Pronase E (Activity ≥ 4000 U/mg)	9036-06-0
  Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids[1].

  

• HY-P0059

  Teriparatide	52232-67-4	99.92%
  Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research[1].

  

• HY-D0150

  Thiazole Orange	107091-89-4	99.78%
  Thiazole orange is an unsymmetrical cyanine dye which can be conjugated to oligonucleotides (ONs) to create fluorogenic hybridisation probes. Thiazole orange can be used for reticulocyte analysis[1][2].

  

• HY-100041

  Bromobimane	71418-44-5
  Bromobimane (Monobromobimane) is a nonfluorescent and converts into fluorescent products when reacts with thiols. Bromobimane has potential applications in labeling thiols[1][2].

  

• HY-138193

  Lauryl maltose neopentyl glycol	1257852-96-2
  Lauryl maltose neopentyl glycol (LMNG) is a detergent that can solubilize and stabilize membrane proteins. Lauryl maltose neopentyl glycol extracts integral membrane proteins from membranes, and improves substantially the stability of various membrane proteins, including G protein-coupled receptors and respiratory complexes[1][2].

  

• HY-103006

  NAI-N3	1612756-29-2
  NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment)[1].

  

• HY-112757

  DLinDMA	871258-12-7
  DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery[1].

  

• HY-15435

  CHAPS	75621-03-3
  CHAPS, a derivative of Cholic acid, is a zwitterionic detergent for solubilizing membrane proteins. CHAPS is used for stabilization of various protein-DNA complexes and can retain biochemical activity of proteins in solution[1][2].

  

• HY-103466

  FM4-64	162112-35-8
  FM4-64 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM4-64 is widely used in endocytic and exospic membrane structure markers.

  

• HY-131614

  TPC2-A1-N	136186-07-7	99.90%
  TPC2-A1-N is a powerful and Ca2+-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells[1][2].

  

• HY-15934

  X-GAL	7240-90-6	99.88%
  X-GAL is a widely used chromogenic β-galactosidase substrate. β-galactosidase cleaves X-gal and produce an insoluble blue compound, which is detectable.

  

• HY-131442

  Alkyne tyramide	1694495-59-4	99.44%
  Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne tyramide substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne tyramide also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins[1].

  

• HY-114299

  Salcaprozate sodium	203787-91-1	99.72%
  Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

  

• HY-12695

  Guanosine 5'-triphosphate trisodium salt	36051-31-7
  Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) is an activator of signal transduction of G proteins[1].

  

• HY-101894

  Dihydrorhodamine 123	109244-58-8
  Dihydrorhodamine 123 (DHR 123) is a fluorescent probe (λex=488 nm, λem=525 nm)[1].

  

• HY-D0937

  Methoxy-PMS	65162-13-2
  Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes[1][2].

  

• HY-108717

  Proteinase K	39450-01-6
  Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection[1][2][3][4].

  

• HY-111772

  Elexacaftor	2216712-66-0	99.50%
  Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].

  

• HY-131615

  TPC2-A1-P		99.77%
  TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3].

  

• HY-A0104

  Hypromellose	9004-65-3
  Hypromellose is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.

  

• HY-111391

  Resazurin sodium	62758-13-8
  Resazurin sodium (Diazoresorcinol sodium) is commonly used to measure bacterial and eukaryotic cell viability through its reduction to the fluorescent product resorufin.

  

• HY-110284

  BAM 15	210302-17-3	99.92%
  BAM 15 is a mitochondrial protonophore uncoupler. BAM 15 is an oxidative phosphorylation (OXPHOS) uncoupler[1].

  

• HY-Y1889

  Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s)	9004-32-4
  Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

  

• HY-N0326

  L-Methionine	63-68-3
  L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

  

• HY-D1027

  Dansylcadaverine	10121-91-2	98.62%
  Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].

  

• HY-128699

  D-Desthiobiotin	533-48-2
  D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography. D-Desthiobiotin also can be used for protein and cell labeling, detection and isolation[1].

  

• HY-B2227

  Lactate	50-21-5
  Lactate (Lactate acid) is the product of glycolysis. Lactate is produced by oxygen lack in contracting skeletal muscle in vivo, and can be removed under fully aerobic conditions. Lactate can be as a hemodynamic marker in the critically ill[1][2].

  

• HY-D1028

  DiD perchlorate	127274-91-3
  DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins[2].

  

• HY-D0090

  MQAE	162558-52-3	99.95%
  MQAE is a novel chloride ion fluorescence probe excited by ultraviolet light. MQAE, binding bromine ion as ligand, can be used to detect the activity of chloride. MQAE exhibits a reduction of fluorescence intensity with the increase of intracellular Cl- concentration. MQAE has a pH-independent fluorescence intensity basically at a Cl- concentration <50 nM. MQAE has high water solubility and cell permeability, MQAE has been used for fluorescence detection such as confocal microscopy and flow cytometry. Ex/Em=350/460 nm[1].

  

• HY-D0857

  HEPES	7365-45-9
  HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[1][2][3].

  

• HY-N0091

  Hypoxanthine	68-94-0
  Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

  

• HY-Y0252

  L-Proline	147-85-3
  L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

  

• HY-Y0781

  Pyruvic acid	127-17-3
  Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.

  

• HY-102023

  GNF351	1227634-69-6	99.90%
  GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1].

  

• HY-15902

  ABTS diammonium salt	30931-67-0	99.83%
  ABTS diammonium salt is a substrate for horseradish peroxidase (HRP) conjugate.

  

• HY-D0098

  Fluorescein-5-maleimide	75350-46-8	99.05%
  Fluorescein-5-maleimide is a fluorescent thiol-reactive dye used to conjugate fluorescein to proteins (excitation: 494 nm, emission: 519 nm).

  

• HY-116677

  Tris(benzyltriazolylmethyl)amine	510758-28-8
  Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand that acts as a biochemical tool for the tagging of proteins and enzymes[1].

  

• HY-N0322A

  Cholesterol (Water Soluble)
  Cholesterol Water Soluble can be used for the research of the effects of cholesterol on the potassium currents in inner hair cells (IHCs). Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer[1][2].

  

• HY-16968

  SW033291	459147-39-8	99.74%
  SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration[1].

  

• HY-N1914

  Ergothioneine	497-30-3
  Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].

  

• HY-Y0842

  Formamide	75-12-7
  Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

  

• HY-B1161

  Methoprene	40596-69-8
  Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[1][2].

  

• HY-W004544

  o-Phenanthroline	66-71-7
  o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].

  

• HY-B2235

  Lecithin	8002-43-5
  Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

  

• HY-Y0016

  Rhodamine B	81-88-9
  Rhodamine B is a staining fluorescent dye, commonly used for dyeing textiles, paper, soap, leather, and drugs.

  

• HY-110251

  DFHBI-1T	1539318-36-9	98.82%
  DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells[1][2].

  

• HY-112292

  GW806742X	579515-63-2
  GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2].

  

• HY-Y0921

  (±)-1,2-Propanediol	57-55-6
  (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs.

  

• HY-W011664

  1,3-Diphenylisobenzofuran	5471-63-6
  1,3-Diphenylisobenzofuran (DPBF) is a fluorescent probe which possesses a highly specific reactivity towards singlet oxygen (1O2) forming an endoperoxide which decomposes to give 1,2-dibenzoylbenzene. 1,3-Diphenylisobenzofuran can detect the generation of reactive oxygen species (ROS)[1][2].

  

• HY-W034551

  DOTA-tri(t-butyl ester)	137076-54-1
  DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging[1].

  

• HY-N0018

  Daidzin	552-66-9	99.77%
  Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.

  

• HY-W040193

  1,2-Distearoyl-sn-glycero-3-phosphorylcholine	816-94-4
  1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

  

• HY-N0098

  Vanillin	121-33-5
  Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.

  

• HY-D0021

  Ethidium bromide	1239-45-8	99.85%
  Ethidium bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis.

  

• HY-129832

  Biotin-azide	908007-17-0	99.92%
  Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry[1][2].

  

• HY-D0984A

  TMRM Perchlorate	115532-50-8
  Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1].

  

• HY-B0400

  D-Sorbitol	50-70-4
  D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

  

• HY-128918

  SIS17	2374313-54-7	99.65%
  SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs[1].

  

• HY-103447

  Zearalenone	17924-92-4	98.50%
  Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts[1][2].

  

• HY-113279

  7-Dehydrocholesterol	434-16-2
  7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

  

• HY-137179

  Glyco-diosgenin	1402423-29-3
  Glyco-diosgenin is a synthetic surfactant and detergent for extracting proteins from membranes for structure and function studies, and single-particle cryo-electron microscopy (cryoEM) studies of membrane proteins[1][2].

  

• HY-113424A

  1,2-Dioleoyl-sn-glycero-3-phosphocholine	4235-95-4
  1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.

  

• HY-15925

  Nitro blue tetrazolium chloride	298-83-9
  Nitro blue tetrazolium chloride (NBT) is a substrate for dehydrogenases; is used with the alkaline phosphatase substrate 5-Bromo-4-Chloro-3-Indolyl Phosphate (BCIP) in western blotting and immunohistological staining procedures.

  

• HY-B1142

  Lipoamide	940-69-2
  Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of lipoic acid with ammonia. Lipoamide as a coenzyme to transfer acetyl group and hydrogen in the process of pyruvate deacylation[1][2].

  

• HY-P3152

  Streptavidin	9013-20-1
  Streptavidin is a ∼60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ∼ 0.01 pM[1]. Streptavidin has an immunosuppressive role[2].

  

• HY-139087

  Erastin2	1695533-44-8	99.25%
  Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2].

  

• HY-B0764A

  Bucladesine calcium	938448-87-4	99.52%
  Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.

  

• HY-P1002

  Suc-Leu-Leu-Val-Tyr-AMC	94367-21-2	99.20%
  Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate.

  

• HY-111496

  Sulfo-NHS-SS-Biotin sodium	325143-98-4
  Sulfo-NHS-SS-biotin is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin can be used for the labeling and purifying of cell-surface protein[1].

  

• HY-D1451

  PKH 26	154214-55-8
  PKH 26 is a lipophilic membrane dye and widely used to determine cell proliferation in heterogeneous cells by flow cytometry. It is a red‐fluorescent dye (Ex/Em=551/567nm)[1][2].

  

• HY-15928

  PNPP disodium	4264-83-9
  PNPP (Para-nitrophenyl phosphate) disodium is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays.

  

• HY-D0719

  Fluorescein Diacetate	596-09-8	99.87%
  Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.

  

• HY-12837

  EN460	496807-64-8	99.73%
  EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation[1].

  

• HY-A0083

  Methacholine chloride	62-51-1
  Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].

  

• HY-B1411

  i-Inositol	87-89-8
  i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.

  

• HY-111653

  CycLuc1	1247879-16-8	98.16%
  CycLuc1 is a brain penetrant luciferase substrate.

  

• HY-N0394

  L-Cystine	56-89-3
  L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.

  

• HY-D0717

  DAF-FM DA	254109-22-3
  DAF-FM DA is a reagent to detect and quantify low concentrations of nitric oxide (NO); DAF-FM fluorescence can be detected by any instrument that can detect fluorescein, including flow cytometers, microscopes, fluorescent microplate readers and fluorometers.

  

• HY-D0714

  Tetrazolium Red	298-96-4	99.85%
  Tetrazolium Red(2,3,5-Triphenyltetrazolium chloride; TPTZ) is used to visualize dehydrogenase enzyme activity; initially the tetrazolium solution is colorless but changes to red when it comes into contact with hydrogen.

  

• HY-N1132

  D-(+)-Trehalose	99-20-7
  D-(+)-Trehalose,which is widespread, can be used as a food ingredient and pharmaceutical excipient.

  

• HY-110250

  DFHBI	1241390-29-3	99.39%
  DFHBI is a small molecule that resembles the chromophore of green fluorescent protein (GFP). Spinach and DFHBI are essentially nonfluorescent when unbound, whereas the Spinach-DFHBI complex is brightly fluorescent both in vitro and in living cells.

  

• HY-14929A

  Migalastat hydrochloride	75172-81-5
  Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.

  

• HY-B0430

  D-Pantothenic acid	79-83-4
  D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

  

• HY-16735

  Avoralstat	918407-35-9
  Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].

  

• HY-18756

  NSC-87877	56990-57-9
  NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

  

• HY-34477

  2-Iodoacetamide	144-48-9
  2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2].

  

• HY-W004500

  All-trans-retinal	116-31-4
  All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions, all-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal.

  

• HY-107500

  UVI 3003	847239-17-2	99.72%
  UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.

  

• HY-P1125

  4-CMTB	300851-67-6	99.35%
  4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].

  

• HY-112730

  PEO-IAA	6266-66-6	99.11%
  PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs).

  

• HY-D0837

  Imidazole	288-32-4
  Imidazole is a planar 5-membered ring.

  

• HY-10912

  Fexaramine	574013-66-4	99.29%
  Fexaramine is a potent and selective FXR agonist with an EC50 of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors[1][2].

  

• HY-102055

  JAK2 JH2 Tracer	2101955-00-2	98.03%
  JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2].

  

• HY-112094

  WNK-IN-11	2123489-30-3	99.44%
  WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.

  

• HY-128974

  N-Dodecyl-β-D-maltoside	69227-93-6
  N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a derivatives of pyrene (Py), and it is a alkyl maltopyranoside detergent, especially in transporters and respiratory complexes. N-Dodecyl-β-D-maltoside has also been employed in applications such as in the purification and stabilization of RNA polymerase and detection of protein-lipid interactions[1].

  

• HY-133520

  HBC620	2530162-07-1	99.32%
  HBC620 is a HBC analog. HBC is nonfluorescent in solution, but emits strong fluorescence upon forming tight complex with Pepper RNA aptamer. HBC-Pepper complex can be used to visualize RNA dynamics in live cells[1].

  

• HY-W006057

  3-Methyl-2-oxobutanoic acid	759-05-7
  3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.

  

• HY-N0771

  L-Isoleucine	73-32-5
  L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

  

• HY-W012530

  Phenylpyruvic acid	156-06-9
  Phenylpyruvic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase.

  

• HY-W015806

  3-Pyridineacetic acid	501-81-5
  3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids)[1][2].

  

• HY-P0019A

  Z-Gly-Gly-Arg-AMC acetate	2070009-61-7	99.88%
  Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

  

• HY-15927

  PNPG	2492-87-7	99.91%
  PNPG(4-Nitrophenyl-β-D- glucopyranoside) is a chromogenic β-D-glucosidase substrate, producing a yellow solution upon cleavage.

  

• HY-Y1311

  Malic acid	6915-15-7
  Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.

  

• HY-100612

  T16Ainh-A01	552309-42-9
  T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].

  

• HY-113081

  1-Methyladenosine	15763-06-1
  1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.

  

• HY-P1902A

  Cardiotoxin Analog (CTX) IV (6-12) (TFA)		99.88%
  Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin[1].

  

• HY-W050026

  Phenylacetylglutamine	28047-15-6
  Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

  

• HY-W051723

  (R)-3-Hydroxybutanoic acid	625-72-9
  (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].

  

• HY-B0964

  Riboflavin phosphate sodium	130-40-5
  Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism[1][2]. Riboflavine phosphate sodium is a very effective NAD+-recycling agent[3].

  

• HY-D0178

  1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride	25952-53-8
  1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2].

  

• HY-101464

  ML329	19992-50-8
  ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.

  

• HY-N0717

  L-Valine	72-18-4
  L-Valine (Valine) is a new nonlinear semiorganic material[1].

  

• HY-107353

  Gadopentetic acid	80529-93-7
  Gadopentetic acid (Gd-DTPA) is a paramagnetic contrast agent. Gadopentetic acid commonly implemented by a bolus intravenous injection in Dynamic contrast-enhanced MRI (DCE-MRI) studies. Gadopentetic acid also can be used for the research of nephrogenic systemic fibrosis (NSF)[1][2].

  

• HY-113485

  Melanin	8049-97-6
  Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.

  

• HY-136151

  UNC10217938A	1347749-97-6	99.27%
  UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides[1].

  

• HY-113253A

  N8-Acetylspermidine dihydrochloride	34450-15-2
  N8-Acetylspermidine dihydrochloride is a polyamine.

  

• HY-D0822

  CY3	146368-13-0
  Cy3 (Sulfo-Cyanine3) is an orange-fluorescent label for protein and nucleic acid (λex=554, λem=568).

  

• HY-N2041

  Myristic acid	544-63-8
  Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.

  

• HY-101398

  Coproporphyrin III	14643-66-4
  Coproporphyrin III (Zincphyrin) is a naturally occurring porphyrin derivative that is mainly found in urine[1][2].

  

• HY-112904

  XRK3F2	2375193-43-2	98.85%
  XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain.

  

• HY-138171

  Lipid 5	2089251-33-0
  Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].

  

• HY-W009362

  DL-Isocitric acid trisodium salt	1637-73-6
  DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is a substrate in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products, including fruit juices.

  

• HY-104009A

  GSK2807 Trifluoroacetate	2245255-66-5
  GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM[1][2].

  

• HY-D0989

  Rhod-2 AM	145037-81-6
  Rhod-2 is a high-affinity visible light excitation wavelength CaCa2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm[1].

  

• HY-66022

  5-FAM	76823-03-5	99.56%
  5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm[1].

  

• HY-112634

  SIRT5 inhibitor 1	2166487-21-2
  SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.

  

• HY-113128

  sn-Glycerol 3-phosphate	17989-41-2
  sn-Glycerol 3-phosphate is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis.

  

• HY-D0824A

  CY7-SE triethylamine
  CY7-SE triethylamine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

  

• HY-D0825

  CY7	943298-08-6
  CY7 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

  

• HY-101895

  Fluorescein di(β-D-galactopyranoside)	17817-20-8
  Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).

  

• HY-D1300

  LysoTracker Red	231946-72-8	98.38%
  LysoTracker Red is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes[1].

  

• HY-136386

  N-Acetyl-D-cysteine	26117-28-2
  N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1].

  

• HY-16670

  Dafadine-A	1065506-69-5	98.94%
  Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).

  

• HY-P0069

  D-JNKI-1	1445179-97-4	99.07%
  D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

  

• HY-18850

  MAPK13-IN-1	229002-10-2	99.63%
  MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.

  

• HY-19700

  trans-Zeatin	1637-39-4	99.83%
  trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.

  

• HY-D0080

  Laurdan	74515-25-6	99.66%
  Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase.

  

• HY-D0184

  2'-Deoxycytidine	951-77-9
  2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).

  

• HY-D0799

  Sulfo-NHS-LC-Biotin sodium	191671-46-2
  Sulfo-NHS-LC-Biotin sodium is an amine-reactive biotinylation reagent that can be used for antibody labeling[1].

  

• HY-108630

  U-73343	142878-12-4
  U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC[1][2].

  

• HY-B0577

  Latanoprost	130209-82-4	99.81%
  Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

  

• HY-F0002

  NADP sodium salt	1184-16-3
  NADP sodium salt (Sodium NADP), a nicotinamide adenine dinucleotide, is a redox cofactor. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH)[1][2].

  

• HY-108465

  Pyr3	1160514-60-2	99.90%
  Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.

  

• HY-N0379

  D-Mannose	3458-28-4
  D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylation of specific proteins.

  

• HY-N0391

  L-Citrulline	372-75-8
  L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.

  

• HY-N0563

  Alizarin	72-48-0	99.17%
  Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings[1].

  

• HY-N8573

  β-Phellandrene	555-10-2
  β-Phellandrene is obtained from Carum petroselinum. β-Phellandrene can be used to essential oil additives[1].

  

• HY-131033

  L-Azidonorleucine hydrochloride	1454334-76-9
  L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants [1][2].

  

• HY-123533A

  Resorufin sodium salt	34994-50-8	98.83%
  Resorufin sodium salt (NSC 12097 sodium salt) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte[1].

  

• HY-W008772

  4-Hydroxymephenytoin	61837-65-8
  4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate.

  

• HY-12659

  LX7101	1192189-69-7	99.75%
  LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM.

  

• HY-12693

  R(+)-IAA-94	54197-31-8	99.03%
  R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef)[1][2][3].

  

• HY-B1028

  Pantethine	16816-67-4
  Pantethine is a dimeric form of pantothenic acid, is an intermediate in the production of Coenzyme A, is available as a dietary supplement, and is used to treat acne and improve the blood-cholesterol profile.

  

• HY-100230A

  ML133 hydrochloride	1222781-70-5	99.90%
  ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

  

• HY-111919

  3-Nitrocoumarin	28448-04-6
  3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor[1].

  

• HY-125924

  DSPE-PEG(2000)-Amine	474922-26-4
  DSPE-PEG(2000)-Amine, an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents[1][2][3].

  

• HY-W020044

  DL-alpha-Tocopherol	10191-41-0	99.57%
  DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].

  

• HY-50694

  Senicapoc	289656-45-7	99.88%
  Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM[1].

  

• HY-15922

  Luminol	521-31-3
  Luminol is a chemical that exhibits chemiluminescence with pKa values of 6.74 and 15.1. Luminol exhibits chemiluminescence (CL) at 425 nm λmax. Luminol is commonly used in forensics as a diagnostic tool for the detection of blood stains[1].

  

• HY-D0023

  Pyranine	6358-69-6
  Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu+ ion(λex=450 nm, λem=510 nm)[1][2][3].

  

• HY-N0668

  Rubusoside	64849-39-4
  Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.

  

• HY-Y0030

  3-Hydroxypicolinic acid	874-24-8
  3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

  

• HY-101794

  2-(Pyridyldithio)ethylamine hydrochloride	106139-15-5
  2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.

  

• HY-113061

  Pseudouridine	1445-07-4	99.93%
  Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation[1][2][3][4].

  

• HY-114202

  delta-Valerobetaine	6778-33-2
  delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO).

  

• HY-139200

  DOTMA	104872-42-6
  DOTMA, as a tetra-methylated DOTA analogue, is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction[1][2][3].

  

• HY-N0615

  Notoginsenoside R1	80418-24-2
  Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].

  

• HY-D0971

  Pyronin Y	92-32-0
  Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells[1][2][5].

  

• HY-N0568

  Madecassoside	34540-22-2
  Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.

  

• HY-N7131

  Coumarin 6	38215-36-0
  Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems[1].

  

• HY-Y0051

  5-Hydroxymethylfurfural	67-47-0
  5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.

  

• HY-125746

  BODIPY-Cholesterol	878557-19-8
  BODIPY-cholesterol is an intrinsically lipophilic, and cell-permeable analog of cholesterol with a fluorescent BODIPY group. BODIPY-cholesterol can be used to monitor sterol uptake and inter-organelle sterol flux in cells. (Excitation/Emission: 480/508 nm)[1].

  

• HY-130015

  HKSOX-1 (5/6-mixture)		98.99%
  HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical[1].

  

• HY-131034

  LP-922056	1365060-22-5	98.08%
  LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats[1][2].

  

• HY-13019

  BI605906	960293-88-3	99.70%
  BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.

  

• HY-12542A

  Dantrolene sodium hemiheptahydrate	24868-20-0
  Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.

  

• HY-D0183

  ATP-polyamine-biotin	1800401-93-7	99.63%
  ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells[1].

  

• HY-D0858

  MES	4432-31-9
  MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments[1][2].

  

• HY-N0658

  L-Threonine	72-19-5
  L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].

  

• HY-Z0816

  Dehydronitrosonisoldipine	87375-91-5
  Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders[1].

  

• HY-112633

  SMN-C3	1449597-34-5	99.89%
  SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA).

  

• HY-113217

  Cholesteryl oleate	303-43-5
  Cholesteryl oleate is an esterified form of Cholesterol. Cholesteryl oleate can be used in the generation of solid lipid nanoparticle (SLN, a nanoparticle-based method for gene therapy)[1][2].

  

• HY-113414

  Deoxycorticosterone	64-85-7	99.57%
  Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.

  

• HY-108943

  Sabinene	3387-41-5
  Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2].

  

• HY-15944

  5(6)-TAMRA	98181-63-6	99.72%
  5(6)-TAMRA contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; bright, orange-fluorescent dye produces conjugates with absorption/emission maxima of ~555/580 nm.

  

• HY-129217

  Naringinase	9068-31-9
  Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis[1][2].

  

• HY-135056

  MitoTracker Green FM	201860-17-5
  MitoTracker Green FM is a green-fluorescent dye that can selectively accumulate in the mitochondrial matrix. MitoTracker Green FM covalently binds to mitochondrial proteins by reacting with free thiol groups of cysteine residues[1].

  

• HY-D0819A

  CY5-SE triethylamine salt	1497420-70-8
  Cy5-SE (Cy5 NHS Ester) triethylamine salt is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Cy5-SE triethylamine salt is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides Ex=649 nm; Em=670 nm)[1].

  

• HY-D1005A

  Poloxamer 188	691397-13-4	99.60%
  Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models[1].

  

• HY-W048205

  N6-Diazo-L-Fmoc-lysine	159610-89-6	99.36%
  N6-Diazo-L-Fmoc-lysine is an active compand and can be used in a variety of chemical studies.

  

• HY-16686

  α-Tocopherol phosphate	38976-17-9
  α-Tocopherol phosphate is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from plant sources.

  

• HY-107985A

  (R)-FT671	1959551-27-9	98.57%
  (R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective USP7 inhibitor[1].

  

• HY-D0893

  NSP-SA-NHS	199293-83-9
  NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed[1].

  

• HY-D0986

  TMA-DPH	115534-33-3
  TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm).

  

• HY-D0987

  Stains-All	7423-31-6	99.91%
  Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP)[1][2].

  

• HY-131166

  Curdlan	54724-00-4
  Curdlan is a polysaccharide produced by bacteria and a homopolymer of glucose with β-1,3-glucosidic linkage[1].

  

• HY-W009884

  Acetosyringone	2478-38-8	99.53%
  Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself[1]. Acetosyringone enhances efficient Dunaliella transformation of Agrobacterium strains[2].

  

• HY-W042416

  N,N-Dimethylacetamide	127-19-5
  N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent.

  

• HY-D0720

  Lucigenin	2315-97-1
  Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm[1].

  

• HY-N0787

  Cryptochlorogenic acid	905-99-7	99.88%
  Cryptochlorogenic acid is a natural product.

  

• HY-116522

  AR420626	1798310-55-0	98.58%
  AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin-induced changes in motility of isolated muscle strips from rat colon and suppresses serotonin-induced fecal output in rats[1].

  

• HY-U00451

  ATP-Red 1	1847485-97-5
  ATP-Red 1 is a multisite-binding switchable fluorescent probe, and can selectively and rapidly responds to intracellular concentrations of ATP in living cells.

  

• HY-P3267

  Transferrins	11096-37-0
  Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron[1][2][3].

  

• HY-101792

  RG7800	1449598-06-4	99.86%
  RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

  

• HY-D0915

  Brilliant Blue FCF	3844-45-9
  Brilliant Blue FCF has the appearance of a reddish-blue powder.

  

• HY-N1463

  Luteolin 7-O-glucuronide	29741-10-4
  Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

  

• HY-P1029

  MLCK inhibitor peptide 18	224579-74-2	99.66%
  MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

  

• HY-100486

  BTTAA	1334179-85-9
  BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.

  

• HY-W004260

  Arachidic acid	506-30-9
  Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

  

• HY-W010970

  5'-Guanylic acid disodium salt	5550-12-9
  5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes[1].

  

• HY-F0002A

  NADP disodium salt	24292-60-2	99.12%
  NADP disodium salt (Disodium NADP), a nicotinamide adenine dinucleotide, is a redox cofactor. NADP disodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH)[1][2].

  

• HY-D0236

  Congo Red	573-58-0
  Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.

  

• HY-14799

  Palovarotene	410528-02-8	99.49%
  Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.

  

• HY-40135

  L-Hydroxyproline,BioReagent, suitable for cell culture	51-35-4
  L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

  

• HY-B1384

  Retinyl palmitate	79-81-2
  Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations.

  

• HY-D0214

  Rose Bengal sodium	632-69-9
  Rose Bengal sodium, a synthetic fluorescein derivative, and is a crimson-coloured dye with the principal component being 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. Rose Bengal sodium has been widely used as an ophthalmic diagnostic agents, and can detect desiccated or damaged cells on the ocular surface. Rose Bengal sodium exhibits antiviral activities[1][2].

  

• HY-D0826

  Cy2-SE (iodine)	186205-33-4
  Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

  

• HY-P2295

  Dabcyl-KTSAVLQSGFRKME-Edans TFA		99.48%
  Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection[1][2][3].

  

• HY-Y1275

  N-Methylpyrrolidone	872-50-4
  N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2].

  

• HY-10167A

  Tecalcet Hydrochloride	177172-49-5	99.74%
  Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].

  

• HY-101899

  Monochlorobimane	76421-73-3
  Monochlorobimane (Chlorobimane) is a fluorescent dye (λex=380 nm, λem=470 nm) to measure glutathione (GSH) in cellular assays[1].

  

• HY-116425

  N-1-Naphthylphthalamic acid	132-66-1	99.67%
  N-1-Naphthylphthalamic acid is a polar auxin transport inhibitor. N-1-Naphthylphthalamic acid disrupts leaf initiation, KNOX protein regulation, and formation of leaf margins in maize[1].

  

• HY-126403

  Ethoxylated hydrogenated castor oil	61788-85-0
  Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo[1].

  

• HY-W001171

  3-Hydroxyanthranilic acid	548-93-6
  3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.

  

• HY-N0424

  Cyclogalegenin	84605-18-5
  Cyclogalegenin (Cyclogalegigenin) is a isoprenoid found in Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol[1].

  

• HY-N0681

  D-Pantothenic acid hemicalcium salt	137-08-6
  D-Pantothenic acid hemicalcium salt (Vitamin B5 calcium salt), a vitamin, can reduce the patulin content of the apple juice.

  

• HY-111548

  Spastazoline	2351882-11-4	99.27%
  Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1].

  

• HY-139853

  BMS-986278	2170126-74-4	99.60%
  BMS-986278 is a potent and orally active lysophosphatidic acid receptor 1 (LPA1) antagonist, with Kbs of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. BMS-986278 can be used for the research of pulmonary fibrotic diseases[1].

  

• HY-B2221B

  Hydroxyethyl cellulose	9004-62-0
  Hydroxyethyl cellulose is a non-ionic, modified cellulose polymer used as a thickening agent for aqueous cosmetic and personal care formulations.

  

• HY-12278

  K02288	1431985-92-0	99.66%
  K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.

  

• HY-110195

  Smurf1-IN-A01	1007647-73-5	99.90%
  Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1].

  

• HY-D0993

  Acridine Orange 10-Nonyl Bromide	75168-11-5
  Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).

  

• HY-B0891

  17α-Hydroxyprogesterone	68-96-2	99.94%
  17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

  

• HY-D0256

  Direct Black 38	1937-37-7
  Direct Black 38 (Chlorazol Black E) is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].

  

• HY-103240

  Methoxy-X04	863918-78-9	98.46%
  Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques.

  

• HY-111613

  Pinaverium bromide	53251-94-8
  Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

  

• HY-113080

  N-Acetylornithine	6205-08-9
  N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.

  

• HY-113298

  Citraconic acid	498-23-7
  Citraconic acid belongs to the class of organic compounds known as methyl-branched fatty acids.

  

• HY-113325

  NADP	53-59-8
  NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH)[1][2].

  

• HY-115521

  Jarin-1	1212704-51-2
  Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC50 of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants[1][2].

  

• HY-140739

  DSPE-PEG-Maleimide (MW 2000)
  DSPE-PEG-Maleimide (MW 2000) is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG-Maleimide (MW 2000) can be used for compose liposomes[1].

  

• HY-14290A

  Pinacidil monohydrate	85371-64-8
  Pinacidil (P-1134) monohydrate, an antihypertensive drug, is a potassium channel activator.

  

• HY-145799

  5A2-SC8	1857341-90-2
  5A2-SC8 is a degradable lipid-like compound (ester-based dendrimer) for small RNAs delivery.

  

• HY-B1539A

  Fuchsine base monohydrochloride	632-99-5
  Fuchsine base (monohydrochloride) is a magenta dye, which is certified for use for acid-fast staining with carbol-fuchsin.

  

• HY-15920

  INT	146-68-9
  INT(Iodonitrotetrazolium chloride) is used in various dehydrogenase colorimetric analysis of the electron acceptor.

  

• HY-15926

  ONPG	369-07-3	99.84%
  ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activity.

  

• HY-16714A

  4-Azido-L-phenylalanine hydrochloride	34670-43-4
  4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.

  

• HY-D0974

  Sulforhodamine B sodium salt	3520-42-1	98.88%
  Sulforhodamine B sodium salt is a fluorescent dye with uses spanning from laser-induced fluorescence (LIF) to the quantification of cellular proteins of cultured cells.

  

• HY-12470

  PF-4800567	1188296-52-7	98.00%
  PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).

  

• HY-110204

  Heclin	890605-54-6	99.80%
  Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits several HECT ligases in tissue culture cells (IC50s=6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively)[1].

  

• HY-12489

  Ponceau S	6226-79-5
  Ponceau S (Acid Red 112) is the most commonly used stain for Western blotting. Ponceau S is applied as an acidic aqueous solution. Ponceau S is compatible with antibody-antigen binding, and stains the proteins on the membrane red[1][2].

  

• HY-12524

  Bikinin	188011-69-0	99.96%
  Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR (brassinosteroids) signaling.

  

• HY-13103

  NS 11021	956014-19-0
  NS 11021 is a potent and specific Ca2+-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

  

• HY-41094

  cis-Isolimonenol	22972-51-6
  cis-Isolimonenol ((1S,4R)-p-Mentha-2,8-dien-1-ol) is a chemical composition of essential oil[1].

  

• HY-D0085

  DiSC3(5)	53213-94-8	99.83%
  DiSC3(5) is a fluorescent probe often used as a tracer dye to assess the mitochondrial membrane potential[1].

  

• HY-N0297

  Sinensetin	2306-27-6	99.87%
  Sinensetin is a methylated flavone found in certain citrus fruits.

  

• HY-103194

  KH7	330676-02-3
  KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2].

  

• HY-109506

  DPPC	63-89-8
  DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

  

• HY-112670

  Exo1	75541-83-2	99.81%
  Exo1 is a chemical inhibitor of the exocytic pathway.

  

• HY-138698

  FT206	2278274-34-1	98.03%
  FT206 is an inhibitor of carboxamides as ubiquitin-specific protrase extracted from patent WO 2020033707 A1, example 11-1[1].

  

• HY-101552A

  L,L-Dityrosine	63442-81-9
  L,L-Dityrosine (o,o'-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin[1].

  

• HY-W019711

  trans-Cinnamaldehyde	14371-10-9
  trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate[1]. trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits[2].

  

• HY-15937

  5(6)-FAM SE	117548-22-8
  5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine.

  

• HY-15942

  5-TAMRA	91809-66-4	98.25%
  5-TAMRA (5-Carboxytetramethylrhodamine), SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.

  

• HY-104008

  ACY-957	1609389-52-7	99.87%
  ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].

  

• HY-103028A

  GSK963	2049868-46-2	99.15%
  GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

  

• HY-18570

  1-Naphthaleneacetic acid	86-87-3	99.89%
  1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM[1][2].

  

• HY-B1514

  Allantoic acid	99-16-1
  Allantoic acid is a degradative product of uric acid and associated with purine metabolism[1][2][3].

  

• HY-D0145

  7-Ethoxyresorufin	5725-91-7	98.96%
  7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].

  

• HY-D0914

  Fast Green FCF	2353-45-9
  Fast Green FCF is a sea green triarylmethane food dye.

  

• HY-I0172

  L-tert-Leucine Methyl Ester Hydrochloride	63038-27-7
  L-tert-Leucine Methyl Ester Hydrochloride is a leucine derivative[1].

  

• HY-N0116

  Hematoxylin	517-28-2
  Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 µM.

  

• HY-101409

  O-Acetylserine	5147-00-2
  O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

  

• HY-101981

  Uridine 5'-monophosphate	58-97-9
  Uridine 5'-monophosphate (5'-​Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[1].

  

• HY-107346

  Enbucrilate	6606-65-1
  Enbucrilate (Butyl cyanoacrylate) is a cyanoacrylate ester that has been used as surgical tissue adhesive.

  

• HY-107799

  Castor oil	8001-79-4
  Castor oil is a natural triglyceride and a solvent. Castor oil has a laxative effect and induces labor in pregnant females. Castor oil can be used as a solvent, co-solvent, stabilizing agent and polyol for the formation of polymer-nanoparticle composites[1][2].

  

• HY-150031

  MFI8	694488-83-0	99.44%
  MFI8 is a small molecule inhibitor of mitochondrial fusion[1].

  

• HY-W011527

  Xanthosine	146-80-5
  Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine can increase mammary stem cell population and milk production in cattle and goats[1].

  

• HY-107690

  DMPO	3317-61-1	99.83%
  DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection.

  

• HY-111099

  GLPG1837	1654725-02-6	99.03%
  GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

  

• HY-P1032

  Angiotensin I (human, mouse, rat)	484-42-4	98.39%
  Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

  

• HY-P1036

  Compstatin	206645-99-0	99.84%
  Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].

  

• HY-112066A

  (+)-SHIN1	2443966-90-1	98.13%
  (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1].

  

• HY-B2212

  Dibenzoyl Thiamine	299-88-7	99.52%
  Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.

  

• HY-D1157

  HKPerox-2	2245230-79-7	99.03%
  HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H2O2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively[2].

  

• HY-N2522

  Carboxyatractyloside dipotassium	33286-30-5	99.74%
  Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport[1].

  

• HY-N6771

  Cyclopiazonic acid	18172-33-3
  Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus, is an inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA) and a potent inducer of cell death in plants[1].

  

• HY-113063

  3-Methyl-2-oxovaleric acid	1460-34-0
  3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.

  

• HY-135368

  8pyDTZ	2351898-91-2
  8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission. 8pyDTZ has excellent biocompatibility and superior in vivo sensitivity. 8pyDTZ can be used for in vivo luminescence imaging[1].

  

• HY-W007355

  Skatole	83-34-1
  Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

  

• HY-B0588

  Brinzolamide	138890-62-7	99.61%
  Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research[1][2].

  

• HY-D0048

  5-TAMRA-SE	150810-68-7	98.13%
  5-TAMRA-SE is an amine-reactive fluorescent agent, its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.

  

• HY-B0109A

  Dorzolamide hydrochloride	130693-82-2	99.91%
  Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].

  

• HY-D0027

  7-Amino-4-methylcoumarin	26093-31-2	99.72%
  7-amino-4-methylcoumarin (Coumarin 120) has been used as a fluorogenic probe for many serine proteases.

  

• HY-P0028

  Phalloidin	17466-45-4
  Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome (λex=495 nm, λem=520 nm).

  

• HY-100335

  PCI-33380	1022899-36-0
  PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

  

• HY-B0941

  6-Benzylaminopurine	1214-39-7
  6-Benzylaminopurine is a cytokinin that elicits plant growth and development, also is an inhibitor of respiratory kinase in plants, increases post-harvest life of green vegetables.

  

• HY-12157

  VU 0238429	1160247-92-6	99.99%
  VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

  

• HY-79676

  Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate	93267-04-0
  Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate is an alanine derivative[1].

  

• HY-D0056

  5-Carboxyfluorescein diacetate N-succinimidyl ester	150206-05-6	99.50%
  5-Carboxyfluorescein diacetate N-succinimidyl ester is a cell permeable dye (Ex=492 nm, Em=517 nm). 5-Carboxyfluorescein diacetate N-succinimidyl ester can label cells by covalently binding to intracellular molecules. 5-Carboxyfluorescein diacetate N-succinimidyl ester is used to track lymphocyte migration and proliferation[1].

  

• HY-Y1666

  2,2′-Dipyridyl disulfide	2127-03-9
  2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].

  

• HY-112104

  Meta-Topolin	75737-38-1	99.15%
  Meta-Topolin (m-Topolin) is a highly active aromatic cytokinin.

  

• HY-112514

  1,3,6,8-Tetrahydroxynaphthalene	18512-30-6	99.01%
  1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin[1].

  

• HY-141873

  Wnt/β-catenin agonist 2	943820-93-7	99.80%
  Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction[1]. (From patent WO2007078113A1, compound 39)

  

• HY-111815A

  N4-Acetylcytidine triphosphate sodium	2803886-33-9
  N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates[1].

  

• HY-W013046

  Phosphoribosyl pyrophosphate pentasodium	108321-05-7
  Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP[1].

  

• HY-16663

  ITX3	347323-96-0	98.88%
  ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of drug[1][2].

  

• HY-16693

  LDN-27219	312946-37-5
  LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease[1][2].

  

• HY-N0657

  Pinoresinol Diglucoside	63902-38-5
  Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.

  

• HY-N0652

  2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside	82373-94-2	99.20%
  2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2, although less strongly.

  

• HY-132298

  TDI-10229	2810887-45-5	99.41%
  TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2].

  

• HY-D0169A

  Phenol Red sodium salt	34487-61-1
  Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction[1] [2].

  

• HY-111895B

  Macropa-NH2 TFA	2705054-08-4	98.14%
  Macropa-NH2 TFA is the precursor of Macropa-NCS. Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070 and is a promising therapeutic radionuclide applied in the treatment of soft-tissue metastases[1].

  

• HY-105917

  Endovion	265646-85-3	99.13%
  Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].

  

• HY-17641

  Olumacostat glasaretil	1261491-89-7
  Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

  

• HY-59260

  N-Boc-L-tert-Leucine	62965-35-9
  N-Boc-L-tert-Leucine is a leucine derivative[1].

  

• HY-D1159

  HKOH-1r	2138472-08-7
  HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively[1].

  

• HY-P0222

  PKI(5-24)	99534-03-9	99.94%
  PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

  

• HY-121137

  BMPO	387334-31-8	99.93%
  BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals[1].

  

• HY-123533

  Resorufin	635-78-9
  Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte[1].

  

• HY-136590

  2-Nitrosopyridine	79917-37-6	99.62%
  2-Nitrosopyridine is a nitroso compound that can be used to synthesize antibiotics. 2-Nitrosopyridine can be used as a Click or Diels-Alder derivatization reagent and an excellent dienophile[1][2].

  

• HY-W011428

  Olomoucine	101622-51-9
  Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2]. Olomoucine regulates cell cycle and shows anti-melanin tumor activity[3][4].

  

• HY-W016814

  (Z)-Aconitic acid	585-84-2
  (Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

  

• HY-W052144

  (±) Anabasine	13078-04-1
  (±) Anabasine is a biphasic muscle relaxant.

  

• HY-12772

  Hydroxy Itraconazole	112559-91-8
  Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

  

• HY-B0119

  Risedronic acid sodium	115436-72-1
  Risedronic acid sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.

  

• HY-N0537

  Xylose	58-86-6
  Xylose, a natural product, can be catalyzed into xylulose by xylose isomerase, and it is the key step for anaerobic ethanolic fermentation of xylose.

  

• HY-66021

  6-FAM	3301-79-9	99.88%
  6-FAM (6-Carboxyfluorescein) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid.

  

• HY-D0259

  Erythrosine B	16423-68-0
  Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.

  

• HY-D0996

  LDS-751	181885-68-7
  LDS-751 is a nucleic acid stain principally detecting DNA. LDS-751 has high affinity for DNA and undergoes fluorescence enhancement upon binding, but with maximal emission at 670 nm. LDS-751 and Thiazole orange are used to differentiate erythrocytes, platelets, reticulocytes, and nucleated cells, and both can be excited at 488 nm[1][2][3].

  

• HY-15930

  TMB	54827-17-7	99.86%
  TMB (BM blue) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

  

• HY-B1311

  Proadifen hydrochloride	62-68-0	99.98%
  Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM).

  

• HY-B1335

  Pentetic acid	67-43-6
  Pentetic acid is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater[1].

  

• HY-B2220

  Cellulase	9012-54-8
  Cellulase is an enzyme catalyzing the hydrolysis of certain linkages in cellulose and other carbohydrates.

  

• HY-N0186

  Indole-3-butyric acid	133-32-4	99.90%
  Indole-3-butyric acid (3-indolebutyric acid; IBA) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate.

  

• HY-N0805

  Alisol B 23-acetate	26575-95-1	99.84%
  Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.

  

• HY-N1964

  Gibberellic acid	77-06-5
  Gibberellic Acid is named after a fungus Gibberella fujikuroi . Gibberellic Acid regulates processes of plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time[1].

  

• HY-Y1841

  o-Phenanthroline monohydrate	5144-89-8
  o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor[1][2].

  

• HY-103597

  Thalidomide-O-COOH	1061605-21-7	99.73%
  Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].

  

• HY-112681

  PKC-theta inhibitor	736048-65-0	99.75%
  PKC-theta inhibitor is a selective PKC-θinhibitor, with an IC50 of 12 nM.

  

• HY-112729

  HC-056456	7733-96-2
  HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM).

  

• HY-114362

  DL-alpha-Tocopherol methoxypolyethylene glycol succinate	1309573-60-1
  DL-alpha-Tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) is an amphiphile, acts as a surfactant[1].

  

• HY-125510

  UNC2541	1612782-86-1	99.71%
  UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

  

• HY-D0853A

  DiAzKs hydrochloride	2421187-79-1
  DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe[1][2][3].

  

• HY-W021409

  Tetramethylammonium triacetoxyborohydride	109704-53-2
  Tetramethylammonium triacetoxyborohydride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

  

• HY-B1009

  Ethylenediaminetetraacetic acid trisodium salt	150-38-9
  Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

  

• HY-B1467

  Domiphen bromide	538-71-6	99.49%
  Domiphen bromide is a chemical antiseptic and a quaternary ammonium compound, used as a cationic surfactant.

  

• HY-D0722

  5(6)-CFDA	124387-19-5
  5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes[1][2][3].

  

• HY-N0897

  Corylifol A	775351-88-7
  Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

  

• HY-113085

  3-Hydroxyhippuric acid	1637-75-8	99.64%
  3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

  

• HY-B1897A

  Menadione bisulfite sodium	130-37-0	99.87%
  Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

  

• HY-16011

  NE 10790	152831-36-2
  NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

  

• HY-79494

  Glyoxalic acid	298-12-4
  Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid.

  

• HY-B1410

  Ioversol	87771-40-2
  Ioversol (MP-328) is a nonionic iodinated contrast medium (CM) that is used during a CT scan or x-ray in animal experiment. Ioversol does not damage the blood-brain barrier (BBB) in animal[1][2][3][4].

  

• HY-B2193

  α-Amylase	9000-90-2
  α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

  

• HY-D0042

  NBD-Cl	10199-89-0
  NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups[1].

  

• HY-D0832

  CY5-N3	1621101-43-6
  CY5-N3 is a Cy5-azide, which is a fluorescent dye.

  

• HY-D1080

  EDANS	50402-56-7
  EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET)[1].

  

• HY-D1416

  HMBR	1287651-36-8
  HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant[1].

  

• HY-Y0134

  (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid	71989-18-9
  (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid is a glutamic acid derivative[1].

  

• HY-Y1636

  Fmoc-Arg(Pbf)-OH	154445-77-9
  Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[1].

  

• HY-111377

  Amine-PEG3-Biotin	359860-27-8
  Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group[1].

  

• HY-112498

  Cy3 NHS ester	1393363-07-9	99.45%
  Cy3 NHS ester is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis[1]. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance[2].

  

• HY-113100

  N-Acetylputrescine hydrochloride	18233-70-0
  N-Acetylputrescine hydrochloride is a putrescine derivative.

  

• HY-113126

  3-Hydroxyisobutyric acid	2068-83-9
  3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

  

• HY-113338

  8-Hydroxyguanine	5614-64-2
  8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

  

• HY-113494

  Stigmastanol	83-45-4
  Stigmastanol is the 6-amino derivative isolated from Hypericum riparium. Hypericum riparium A. Chev. is a Cameroonian medicinal plant belonging to the family Guttiferae[1][2].

  

• HY-12798C

  AR-13324 M1 metabolite	2309668-15-1
  AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate. AR-13324 is a inhibitor of ROCK kinase.

  

• HY-134781

  CKK-E12	1432494-65-9
  CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 was highly selective toward liver parenchymal cell in vivo,

  

• HY-136372

  Diquat dibromide hydrate	6385-62-2	99.92%
  Diquat dibromide hydrate is a diazine-like herbicide including two nitrogen atoms[1].

  

• HY-138638

  Sephadex LH 20	9041-37-6
  Sephadex LH 20 could be used for the isolation of natural compounds and food, such as red wine and pigments[1].

  

• HY-139566

  Abrucomstat	100502-66-7
  Abrucomstat (3-Nitroxypropanol) acts as an enzyme inhibitor to decrease ruminal methanogenesis[1][2].

  

• HY-150042

  TDI-011536	2687970-96-1	99.91%
  TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].

  

• HY-B2247A

  PLGA (75:25)	34346-01-5	99.12%
  PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for drugs, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3].

  

• HY-101937B

  L-ANAP hydrochloride		98.51%
  L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

  

• HY-112582C

  N1-Methylpseudouridine-5′-triphosphate trisodium
  N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability[1].

  

• HY-W010964

  Fmoc-Hyp(tBu)-OH	122996-47-8
  Fmoc-Hyp(tBu)-OH is a proline derivative[1].

  

• HY-W040821

  DL-Homocysteine	454-29-5
  DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.

  

• HY-14350

  AC-55541	916170-19-9	99.25%
  AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca2+ mobilization assays and exhibits pronociceptive activity in vivo[1].

  

• HY-B0989

  Carzenide	138-41-0
  Carzenide is an organic synthesis intermediate, for synthetic drug.

  

• HY-G0017

  N-Desmethyl imatinib	404844-02-6
  N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR[1].

  

• HY-N0237

  Atractyloside A	126054-77-1
  Atractyloside A is a natural TCM reference compound.

  

• HY-N0270

  Ononin	486-62-4	99.96%
  Ononin is an isoflavonoid, is an additional growth inhibitor in soils associated with the weed, Pluchea lanceolata.

  

• HY-F0003A

  NADPH tetracyclohexanamine	100929-71-3
  NADPH tetracyclohexanamine is a ubiquitous cofactor and biological reducing agent.

  

• HY-W015798

  2-Iminothiolane hydrochloride	4781-83-3
  2-Iminothiolane hydrochloride is a reagent for the introduction of sulphydryl groups into oligosaccharides derived from asparagine-linked glycans[1].

  

• HY-P0294

  Hexa-His	64134-30-1	98.62%
  Hexa-His is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein.

  

• HY-P0088

  Porcine dynorphin A(1-13)	72957-38-1	99.61%
  Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

  

• HY-109127

  Berotralstat	1809010-50-1	99.70%
  Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE[1][2].

  

• HY-108910

  Chymotrypsin	9004-07-3
  Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids[1][2].

  

• HY-112606

  ML-290	1482500-76-4
  ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

  

• HY-W011793

  4-Thiouridine	13957-31-8
  4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].

  

• HY-12801

  DiZPK	1337883-32-5
  DiZPK is a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.

  

• HY-21268

  Methyl linolenate	301-00-8
  Methyl linolenate is a polyunsaturated fattly acid (PUFA).

  

• HY-B1260

  Cetrimonium bromide	57-09-0
  Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.

  

• HY-D0024

  Sudan I	842-07-9	99.78%
  Sudan I (Solvent Yellow 14) is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus[1].

  

• HY-I0508

  Phthalic acid	88-99-3
  Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].

  

• HY-N2131

  Isosakuranetin	480-43-3	99.88%
  Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia.

  

• HY-107379

  AKR1C3-IN-1	327092-81-9	98.23%
  AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM.

  

• HY-108309

  Medronic acid	1984-15-2
  Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. Medronic acid accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.

  

• HY-112171

  γ-L-Glutamyl-L-alanine	5875-41-2
  γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4].

  

• HY-115640

  TRFS-green	1513848-14-0
  TRFS-green is a highly selective off−on fluorescent probe for imaging thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm[1].

  

• HY-117389

  Homocarbonyltopsentin	172286-77-0	98.22%
  Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM[1].

  

• HY-122464

  (±)-Jasmonic acid	77026-92-7
  (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.

  

• HY-D1491A

  Fast Red Violet LB Zinc chloride
  Fast Red Violet LB Zinc chloride is a dye for staining tartrate resistant acid phosphatase (TRAP). Fast Red Violet LB Zinc chloride can be used for alkaline phosphatase (ALP) activity staining[1][2].

  

• HY-112106A

  Diethyl aminoethyl hexanoate citrate	220439-24-7
  Diethyl aminoethyl hexanoate citrate is a compound that is widely used as a plant growth regulator.

  

• HY-W007376

  Indole-3-carboxaldehyde	487-89-8
  Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin[1].

  

• HY-W041019

  5-Hydroxytryptophol	154-02-9
  5-Hydroxytryptophol is a mammalian serotonin metabolite, acting as a marker of acute alcohol consumption.

  

• HY-W041987

  Fmoc-L-Lys(Dde)-OH	150629-67-7	99.76%
  Fmoc-L-Lys(Dde)-OH is a lysine derivative[1].

  

• HY-W187305

  MASM7	920868-45-7
  MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1].

  

• HY-B0961

  Merbromin	129-16-8
  Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye. Merbromin is a potent inhibitor against Zika virus (ZIKV) replication. Merbromin shows anti-ZIKV potency through ZIKVpro inhibition[1].

  

• HY-B1146

  Denatonium benzoate	3734-33-6
  Denatonium benzoate (THS-839) is the most bitter chemical compound known,used as aversive agents (bitterants) to prevent inappropriate ingestion.

  

• HY-D0047

  5-CFDA	79955-27-4
  5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes[1][2][3].

  

• HY-N0387

  Rhynchophylline	76-66-4	99.94%
  Rhyncholphylline, an alkaloid isolated from Uncaria rhynchophylla, shows potent inhibition of lipopolysaccharide (LPS)-induced NO production in rat primary microglial cells.

  

• HY-N0597

  Panaxatriol	32791-84-7
  Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.

  

• HY-N0696

  Sipeimine	61825-98-7
  Sipeimine is a natural product isolated from Fritillaria ussuriensis.

  

• HY-10593

  IQ 1	331001-62-8	99.69%
  IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion[1].

  

• HY-D0994

  4-Methylumbelliferyl phosphate	3368-04-5	99.96%
  4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant[1][2][3].

  

• HY-145557

  Bezuclastinib	1616385-51-3	98.59%
  Bezuclastinib (CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001<IC50<1 μM; extracted from patent WO2014100620 A2, compound P-2007). Bezuclastinib is a tyrosine kinase inhibitor[1][2].

  

• HY-139142B

  Simufilam hydrochloride	2480226-07-9	99.90%
  Simufilam (PTI-125) hydrochloride, a compound, can be uesd for screening of drug candidate.

  

• HY-101892

  DiBAC4(3)	70363-83-6
  DiBAC4(3) is a voltage-sensitive fluorescent dye (λex=490 nm, λem=505 nm).

  

• HY-12664

  AF64394	1637300-25-4	98.02%
  AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

  

• HY-A0272

  Sodium laureth sulfate	9004-82-4
  Sodium lauryl polyoxyethylene ether sulfate is an anionic surfactant, with excellent decontamination, emulsification, dispersion, wetting, solubilizing performance and foaming property.

  

• HY-D1583

  Cyanine5 DBCO	2360411-64-7	99.65%
  Cyanine5 DBCO (DBCO-Cy5) is a water-soluble, low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm)[1][2].

  

• HY-Y1166

  N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester	84793-07-7
  N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester is a glutamic acid derivative[1].

  

• HY-100600

  BGG463	890129-26-7
  BGG463 (K03859) is an orally active type II CDK2 inhibitor[1].

  

• HY-111647

  N2-Methylguanosine	2140-77-4
  N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.

  

• HY-112820

  Chlorantraniliprole	500008-45-7
  Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

  

• HY-113328

  Aminoadipic acid	542-32-5
  Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.

  

• HY-120821

  Endosidin-2	1839524-44-5	99.42%
  Endosidin2 (ES2) binds to the exocyst component of 70 kDa (EXO70) subunit of the exocyst complex with a Kd of 253 μM. Endosidin2 inhibits exocytosis and endosomal recycling in both plant and human cells and enhances plant vacuolar trafficking. Endosidin2 is a valuable new tool for the study of exocytosis[1].

  

• HY-132868

  SLK/STK10-IN-1	264210-49-3	99.34%
  SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

  

• HY-141140

  5-Ethynyluridine	69075-42-9
  5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2].

  

• HY-W004520

  Phenazine methylsulfate	299-11-6
  Phenazine methylsulfate is a free radical generator. Phenazine methylsulfate has been used as an electron transfer reactant in cell viability assays. Phenazine methylsulfate induces ssDNA break formation in the presence of the reducing agent NADPH. Phenazine methylsulfate induces oxidative DNA damage in an alkaline comet assay and apoptosis.

  

• HY-W008560

  Fmoc-Gly(allyl)-OH	146549-21-5	99.94%
  Fmoc-Gly(allyl)-OH is a Glycine (HY-Y0966) derivative[1].

  

• HY-W008852

  Tetrakis (4-carboxyphenyl) porphyrin	14609-54-2
  Tetrakis (4-carboxyphenyl) porphyrin (TCPP) plays the role of a metal remover[1].

  

• HY-W010893

  Fmoc-2-Nal-OH	112883-43-9
  Fmoc-2-Nal-OH is an alanine derivative[1].

  

• HY-W011210

  Fmoc-Pra-OH	198561-07-8
  Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative[1].

  

• HY-30267

  4-Hydroxyphenyl acetate	3233-32-7	99.92%
  4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor[1].

  

• HY-A0087

  Octocrylene	6197-30-4
  Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. Octocrylene has the potential for using in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation[1].

  

• HY-B0148

  Risedronic acid	105462-24-6
  Risedronic acid (Risedronate ) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.

  

• HY-B0704

  Azelaic acid	123-99-9
  Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.

  

• HY-B0985

  Phenazopyridine hydrochloride	136-40-3	99.88%
  Phenazopyridine hydrochloride is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract.

  

• HY-B1172

  Lactulose	4618-18-2
  Lactulose is a non-absortable sugar used in the treatment of constipation and hepatic encephalopathy.

  

• HY-D0193

  Ponceau 4R	2611-82-7
  Ponceau 4R is a synthetic colourant that may be used as a food colouring.

  

• HY-D0913

  1-Methyl-7-nitroisatoic anhydride	73043-80-8
  1-methyl-7-nitroisatoic anhydride (1M7) is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

  

• HY-Y0335

  1,3-Dihydroxyacetone	96-26-4
  1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol over Gluconobacter oxydans[1].

  

• HY-D0190

  2-Thenoyltrifluoroacetone	326-91-0
  2-Thenoyltrifluoroacetone is a chelating agent. 2-Thenoyltrifluoroacetone can be used for the complexation of various metal ions including Mn(II), Co(III), Ni(II), et al.. 2-Thenoyltrifluoroacetone possesses antitubercular and cytotoxic activities. 2-Thenoyltrifluoroacetone is also used as common inhibitor of mitochondrial electron flux and to analyze the endothelial cell dysfunction. Besides, copper (II) complex of 2-Thenoyltrifluoroacetone has anticancer activity against K562[1].

  

• HY-19408

  Pyr10	1315323-00-2	98.05%
  Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels[1].

  

• HY-100341

  M2I-1	312271-03-7
  M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC)[1].

  

• HY-15941

  5(6)-FITC	27072-45-3	98.31%
  5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of fluorescein dye that has wide-ranging applications as a label for antibodies and other probes, for use in fluorescence microscopy, flow cytometry and immunofluorescence-based assays such as Western blotting and ELISA.

  

• HY-D0716

  Fluo-3AM	121714-22-5
  Fluo-3 AM is a fluorecent Ca2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence[1].

  

• HY-D0970

  Diphenyl Blue	72-57-1
  Diphenyl Blue (Trypan Blue) is a cell active dye, the most commonly used dye for the identification of dead cells, of en used to test cell membrane integrity and cell viability. Diphenyl Blue staining is one of the methods for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them Blue. Normal living cells with intact cell membranes reject Diphenyl blue and do not stain them blue. However, macrophages are capable of phagocytosis of Diphenyl Blue, so it can be used as a living stain for macrophages[1].

  

• HY-N1430

  Oxyresveratrol	29700-22-9	98.87%
  Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects[1][2][3][4].

  

• HY-103082

  CLK1-IN-1	2123491-32-5	99.05%
  CLK1-IN-1 is a potent and selective of Cdc2-like kinase 1 (CLK1) inhibitor, with an IC50 of 2 nM.

  

• HY-I0109

  (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid	69901-75-3
  (S)-2-(((benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid is a Glycine (HY-Y0966) derivative[1].

  

• HY-I1124

  L-Valine-d8	35045-72-8
  L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].

  

• HY-N0524

  Propyl gallate	121-79-9	99.89%
  Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal[1][2].

  

• HY-N2577

  1F-Fructofuranosylnystose	59432-60-9
  1F-Fructofuranosylnystose can be used in the synthesis of Fructooligosaccharides (FOSs). Fructooligosaccharides exhibit lots of beneficial effects on our health and have been used as food ingredients.

  

• HY-N7092

  D-Fructose	57-48-7
  D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.

  

• HY-N7493

  N-acetyldopamine	2494-12-4	98.85%
  N-acetyldopamine (NADA) is a catecholamine that is used by insects as sclerotizing precursors to harden their cuticle[1].

  

• HY-P0315

  Crosstide	171783-05-4	99.48%
  Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

  

• HY-100582

  Ribitol	488-81-3
  Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.

  

• HY-101411

  4-Acetamidobutanoic acid	3025-96-5
  4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities[1].

  

• HY-101953

  β-Apo-13-carotenone	17974-57-1	98.09%
  β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.

  

• HY-103601

  (S,R,S)-AHPC-PEG4-N3	1797406-81-5	98.77%
  (S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

  

• HY-112103

  6-(γ,γ-Dimethylallylamino)purine	2365-40-4	99.81%
  6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.

  

• HY-113138

  3-Methyluridine	2140-69-4	99.53%
  3-Methyluridine (N3-Methyluridine) is a modified RNA nucleoside. 3-Methyluridine is often presents as RNA modification which can be detected in 23S rRNA of archaea, 16S and 23S rRNA of eubacteria, and 18S, 25S, and 28S of eukaryotic ribosomal RNAs[1][2].

  

• HY-113168

  Butyrylcarnitine	25576-40-3
  Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.

  

• HY-126074

  Z433927330	1005883-72-6	98.01%
  Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1].

  

• HY-128454

  Dimethyl trisulfide	3658-80-8
  Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote[1].

  

• HY-135087

  Caprylic/Capric Triglyceride	65381-09-1
  Caprylic/Capric Triglyceride is the triglycerides and esters prepared from fractionated vegetable oil sources and fatty acids from coconuts and palm kernel oils. Caprylic/Capric Triglyceride possesses excellent oxidation stability. Caprylic/Capric Triglyceride is used as a food additive and used in cosmetics[1][2][3].

  

• HY-100061A

  2-(Dimethylamino)acetaldehyde hydrochloride	125969-54-2
  2-(Dimethylamino)acetaldehyde hydrochloride can be used to synthesis Muscarine analogues[1].

  

• HY-W007408

  tert-Butyl 2-aminoacetate	6456-74-2	99.64%
  tert-Butyl 2-aminoacetate is a Glycine (HY-Y0966) derivative[1].

  

• HY-W008196

  H-Lys(Fmoc)-OH	84624-28-2
  H-Lys(Fmoc)-OH is a lysine derivative[1].

  

• HY-W008872

  Fmoc-Lys(Mtt)-OH	167393-62-6	99.61%
  Fmoc-Lys(Mtt)-OH is a lysine derivative[1].

  

• HY-W009110

  (S)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid	261165-06-4
  (S)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a phenylalanine derivative[1].

  

• HY-W010862

  Fmoc-Lys(Alloc)-OH	146982-27-6
  Fmoc-Lys(Alloc)-OH is a lysine derivative[1].

  

• HY-W010982

  Fmoc-Phe(4-NH2)-OH	95753-56-3
  Fmoc-Phe(4-NH2)-OH is a phenylalanine derivative[1].

  

• HY-W011151

  trans-Zeatinriboside	6025-53-2	99.65%
  trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.

  

• HY-W012185

  (-)-Sparteine	90-39-1
  (-)-Sparteine is a natural alkaloid isolated from beans.

  

• HY-W015495

  L-Dihydroorotic acid	5988-19-2
  L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme[1].

  

• HY-W020014

  Pyruvic aldehyde	78-98-8
  Pyruvic aldehyde is often used as a reagent in organic synthesis, as a flavoring agent, and in tanning.

  

• HY-12346

  FH1	2719-05-3	99.42%
  FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps)[1].

  

• HY-16689

  VU 0240551	893990-34-6	99.56%
  VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].

  

• HY-B0027

  Valnemulin hydrochloride	133868-46-9	98.30%
  Valnemulin hydrochloride is a pleuromutilin antibiotic which inhibits protein synthesis in bacteria by binding the peptidyl transferase enzyme in the 50s ribosomal subunit.

  

• HY-B0600

  Tafluprost	209860-87-7
  Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.

  

• HY-B0892

  Benzyl alcohol	100-51-6	99.95%
  Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.

  

• HY-B1008

  4-Aminobenzoic acid	150-13-0
  4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

  

• HY-N0541

  Pseudoginsenoside F11	69884-00-0
  Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

  

• HY-D0307A

  Amaranth	915-67-3	99.73%
  Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics.

  

• HY-W012642

  2-Aminopurine	452-06-2
  2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2].

  

• HY-W076836

  4-Aminobenzaldehyde	556-18-3
  4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals[1].

  

• HY-18772

  O4I2	165682-93-9	99.42%
  O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1[1].

  

• HY-D0012

  Bromothymol Blue	76-59-5
  Bromothymol Blue is a pH indicator.

  

• HY-D0017

  Dansyl chloride	605-65-2
  Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts.

  

• HY-101897

  Fura-2 AM	108964-32-5
  Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca2+ indicator.

  

• HY-P2536

  Mca-Ala-Pro-Lys(Dnp)-OH	305336-82-7	98.99%
  Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2].

  

• HY-101891

  Di-8-ANEPPS	157134-53-7	99.46%
  Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in Vm .

  

• HY-D0935A

  4-Methylumbelliferyl-β-D-glucuronide hydrate	881005-91-0	99.93%
  4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli[1][2][3].

  

• HY-19933

  Vibegron	1190389-15-1	98.82%
  Vibegron (MK-4618) is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder[1][2][3].

  

• HY-23524

  HSL-IN-3	346656-34-6
  HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL)[1].

  

• HY-34515

  3,4,7,8-Tetramethyl-1,10-phenanthroline	1660-93-1
  3,4,7,8-Tetramethyl-1,10-phenanthroline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

  

• HY-41324

  7-keto-Deoxycholic acid	911-40-0	98.32%
  7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2].

  

• HY-65000

  H-Lys(Boc)-OMe hydrochloride	2389-48-2
  H-Lys(Boc)-OMe hydrochloride is a lysine derivative[1].

  

• HY-A0145

  Phenprocoumon	435-97-2	98.09%
  Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.

  

• HY-B1426

  Iodixanol	92339-11-2	99.92%
  Iodixanol is an iodine-containing non-ionic radiocontrast agent[1].

  

• HY-D0073

  2,3-Diaminonaphthalene	771-97-1
  2,3 Diaminonaphthalene is a highly selective colorimetric and fluorometric reagent for selenium detection and also used for the fluorometric determination of nitrite.

  

• HY-P1006

  Ac-DEVD-pNA	189950-66-1	98.89%
  Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

  

• HY-P1027

  LEP(116-130)(mouse)	258276-95-8
  LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

  

• HY-111603

  Calcium dobesilate	20123-80-2
  Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

  

• HY-113411

  3-Hydroxyglutaric acid	638-18-6	98.85%
  3-Hydroxyglutaric acid is a glutaric acid derivative.

  

• HY-116285

  n-Octyl β-D-glucopyranoside	29836-26-8
  n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins[1][2].

  

• HY-120601

  Alizarin Red S sodium	130-22-3
  Alizarin Red S sodium (ARS sodium) is an anthraquinone dye that has been widely used to evaluate calcium deposits in cell culture[1].

  

• HY-126839

  C12FDG	138777-25-0
  C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) is a lipophilic green fluorescent substrate for β-galactosidase detection. C12-FDG is more sensitive than FDG (HY-101895) for beta-galactosidase activity determinations in animal cells[1].

  

• HY-129096

  IDT307	1141-41-9	99.10%
  IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].

  

• HY-130017

  HKSOX-1r (5/6-mixture)		98.68%
  HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical[1].

  

• HY-147092

  Oryzalin	19044-88-3	99.77%
  Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin depolymerizes MTs and prevented the polymerization of new MTs at all stages of the mitotic cycle[1].

  

• HY-117226A

  GSK 690 Hydrochloride		99.16%
  GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.

  

• HY-W002292

  L-Homoserine	672-15-1
  L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.

  

• HY-W008029

  H-Lys(Z)-OtBu.HCl	5978-22-3
  H-Lys(Z)-OtBu.HCl is a lysine derivative[1].

  

• HY-W008344

  2-Chloroadenosine	146-77-0
  2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].

  

• HY-W012078

  5-Methyl-2'-deoxycytidine	838-07-3	99.85%
  5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation[1][2].

  

• HY-W074143

  Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride	36309-88-3
  Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is an oxygen-sensitive fluorescent indicator widely used as a probe for luminescence detection and quantitative oxygen determination[1].

  

• HY-W011704A

  Phosphoenolpyruvic acid tricyclohexylammoniu​m salt	35556-70-8
  Phosphoenolpyruvic acid tricyclohexylammoniu​m salt is a glycolysis metabolite with a high-energy phosphate group, penetrates the cell membrane and exhibits cytoprotective and anti-oxidative activity[1].

  

• HY-14179

  PPQ-102	931706-15-9	99.82%
  PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].

  

• HY-15909

  BCIP	6578-06-9
  BCIP(BCIP p-toluidine salt; X-phosphate p-toluidine salt) is an artificial chromogenic substrate used for the sensitive colorimetric detection of alkaline phosphatase activity.

  

• HY-18253

  Udenafil	268203-93-6	99.86%
  Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research[1][2].

  

• HY-18593

  6-O-α-Maltosyl-β-cyclodextrin	104723-60-6
  6-O-α-Maltosyl-β-cyclodextrin is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.

  

• HY-B0797

  Etretinate	54350-48-0	98.04%
  Etretinate(Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis treatment.

  

• HY-B1234

  Octinoxate	5466-77-3
  Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage.

  

• HY-N0910

  Notoginsenoside Ft1	155683-00-4
  Notoginsenoside Ft1 is a saponin isolated from Panax notoginseng; stimulator of angiogenesis.

  

• HY-114544A

  N-3-oxo-dodecanoyl-L-homoserine lactone	168982-69-2
  N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[1][2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells[3].

  

• HY-W068697

  3-Butenoic acid	625-38-7
  3-Butenoic acid (Vinylacetic acid) can be used to synthesize bicyclic 3,6-dihydro-1,2-oxazine. Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene[1][2].

  

• HY-G0023

  Niraparib metabolite M1	1476777-06-6	99.70%
  Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

  

• HY-18874

  p38-α MAPK-IN-1	443913-15-3	99.89%
  p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].

  

• HY-D1044

  Rhodamine 101 chloride	64339-18-0
  Rhodamine 101 chloride (Rhodamine 640 chloride) is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively[1].

  

• HY-133531

  PDD00017272	1945950-20-8	98.18%
  PDD00017272 (34f) is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with EC50 of 4.8 nM and 9.2 nM in biochemical assay and cell POM, respectively[1].

  

• HY-B0833

  Thiamethoxam	153719-23-4	99.87%
  Thiamethoxam is a broad spectrum neonicotinoid insecticide[1][2].

  

• HY-109152

  Navocaftor	2159103-66-7	99.05%
  Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1)[1].

  

• HY-109191

  Sovesudil	1333400-14-8	98.31%
  Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia[1][2].

  

• HY-P1036A

  Compstatin TFA		99.46%
  Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3].

  

• HY-18407

  N-Methylisatoic anhydride	10328-92-4
  N-Methylisatoic anhydride (NMIA) is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology[1].

  

• HY-21509

  8-Hydroxycoumarin	2442-31-1	99.95%
  8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone[1].

  

• HY-23926

  PYBG	680622-71-3	99.64%
  PYBG acts as a versatile precursor to be facilely conjugated with various fluorescent dyes through ‘Click chemistry’ and Sonogashira coupling reactions[1].

  

• HY-34597

  (S)-2-Amino-3-(4-bromophenyl)propanoic acid	24250-84-8
  (S)-2-Amino-3-(4-bromophenyl)propanoic acid is a phenylalanine derivative[1].

  

• HY-41650

  Boc-Ala-NMe(OMe)	87694-49-3	99.98%
  Boc-Ala-NMe(OMe) is an alanine derivative[1].

  

• HY-B1571

  Bromophenol blue	115-39-9
  Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6[1][2].

  

• HY-B1768

  Succimer	304-55-2
  Succimer is a widely used chelating agent for the treatment of Pb poisoning.

  

• HY-D0257

  Tartrazine	1934-21-0
  Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.

  

• HY-D1148

  HKGreen-4I	1448821-82-6	99.29%
  HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of H2O2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively[2].

  

• HY-D1282

  Fluorofurimazine	2412089-96-2
  Fluorofurimazine is fluorogenic substrate for Antares. Fluorofurimazine can realize sensitive bioluminescence imaging to prolong the generation of high-sensitivity light. Fluorofurimazine has good aqueous solubility allows delivery of higher doses to mice. Fluorofurimazine can be used in the bioluminescence imaging[1].

  

• HY-D1506

  Fl-DIBO	1407523-31-2	99.28%
  Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference[1][2].

  

• HY-I0301

  D-(+)-Glucono-1,5-lactone	90-80-2
  D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

  

• HY-N0466

  Rebaudioside A	58543-16-1
  Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.

  

• HY-N1938

  D(+)-Raffinose pentahydrate	17629-30-0
  D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate) is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. D(+)-Raffinose pentahydrate is a functional oligosaccharide.

  

• HY-N2327

  Oleamide	301-02-0
  Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.

  

• HY-N6824

  Hydroxy-β-sanshool	97465-69-5	99.36%
  Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil[1].

  

• HY-P0295

  Gly-Arg-Gly-Asp-Ser	96426-21-0	99.87%
  Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[1]

  

• HY-Y0511

  N-Methylsarcosine	1118-68-9
  N-Methylsarcosine is an amino acid building block for protein, found in a small amount in the body.

  

• HY-Y1088

  Hydrocinnamic acid	501-52-0	99.97%
  Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.

  

• HY-Z0424

  (S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester	170848-34-7
  (S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester is an alanine derivative[1].

  

• HY-100551

  meso-Erythritol	149-32-6
  meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80% as sweet as sucrose, and is an approved low-calorie sweetener food additive[1].

  

• HY-101399

  γ-Glu-Phe	7432-24-8	99.82%
  γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth[1].

  

• HY-107616

  H2L5186303	139262-76-3	98.72%
  H2L5186303 is a potent and selective LPA2 receptor (lysophosphatidic acid 2 receptor) antagonist with an IC50 of 9 nM[1].

  

• HY-112755

  DODMA	104162-47-2
  DODMA, a cationic lipid, is used for the preparation of liposomes[1].

  

• HY-113011

  Maltotriose	1109-28-0
  Maltotriose, the second most abundant sugar present in brewing, is an inducer of the maltose regulon of Escherichia coli. Maltotriose can induce beta-galactosidase synthesis[1][2].

  

• HY-113101

  2-Hydroxyadipic acid	18294-85-4
  2-Hydroxyadipic acid is an organic acid, formed by the reduction of 2-ketoadipic acid.

  

• HY-113135

  5-Methylcytidine	2140-61-6
  5-Methylcytidine is a pyrimidine nucleoside detected in multiple biofluids.

  

• HY-113286

  4-Guanidinobutanoic acid	463-00-3
  4-Guanidinobutanoic acid is a normal metabolite present in low concentrations.

  

• HY-114712

  SJ572403	19970-45-7	98.54%
  SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1].

  

• HY-126793

  2′,7′-Dichlorofluorescein diacetate	2044-85-1
  2′,7′-Dichlorofluorescein diacetate (DCFH-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon[1].

  

• HY-141415

  Polysorbate 20	9005-64-5
  Polysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3].

  

• HY-18569S

  3-Indoleacetic acid-d5	76937-78-5	99.84%
  3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].

  

• HY-D1156A

  HKSOX-1m (5/6-mixture) (hydrobromide)		99.55%
  HKSOX-1m (5/6-mixture) hydrobromide is a O2•− fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2•− over a broad range of pH, strong oxidants, and abundant reductants found in cells[1].

  

• HY-N1132A

  D-(+)-Trehalose dihydrate	6138-23-4
  D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.

  

• HY-N5112A

  β,β-Dimethylacrylalkannin	34539-65-6
  β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells[1].

  

• HY-Y1889A

  Sodium carboxymethyl cellulose (MW 250000)	9004-32-4
  Sodium carboxymethyl cellulose (CMC-Na) (MW 250000) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.

  

• HY-135414B

  Cyanine5 NHS ester iodide		99.95%
  Cyanine5 NHS ester iodide is a red emitting fluorescent dye for labeling of amino-groups in peptides, proteins, and oligonucleotides[1].

  

• HY-W000795

  (S)-2-amino-3-(4-benzoylphenyl)propanoic acid	104504-45-2
  (S)-2-amino-3-(4-benzoylphenyl)propanoic acid is an alanine derivative[1].

  

• HY-W001179

  2,5-Dihydroxybenzoic acid	490-79-9	99.97%
  2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

  

• HY-W001963

  Pyrrole-2-carboxylic acid	634-97-9
  Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.

  

• HY-W004283

  Pentadecanoic acid	1002-84-2
  Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

  

• HY-W004547

  (NH2)2bpy	18511-69-8
  (NH2)2bpy is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

  

• HY-W005144

  Boc-Lys(Fmoc)-OH	84624-27-1
  Boc-Lys(Fmoc)-OH is a lysine derivative[1].

  

• HY-W005241

  5-Hydroxymethyl-2-furancarboxylic acid	6338-41-6
  5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.

  

• HY-W008661

  Deoxyguanosine triphosphate trisodium salt	93919-41-6
  Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification[1].

  

• HY-W009204

  Fmoc-Ala-OH	35661-39-3	99.91%
  Fmoc-Ala-OH is an alanine derivative[1].

  

• HY-W010724

  Fmoc-D-Cys(Trt)-OH	167015-11-4
  Fmoc-D-Cys(Trt)-OH is a cysteine derivative[1].

  

• HY-W012906

  (S)-2-Allylglycine	16338-48-0
  (S)-2-Allylglycine is a peptide derivative.

  

• HY-W013714

  Fmoc-Phe(4-I)-OH	82565-68-2
  Fmoc-Phe(4-I)-OH is a phenylalanine derivative[1].

  

• HY-W040329

  2'-Deoxyadenosine	958-09-8
  2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.

  

• HY-W040804

  2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride	4876-14-6
  2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride is an alanine derivative[1].

  

• HY-12884

  OAC2	6019-39-2	99.57%
  OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.

  

• HY-18102

  GLPG0492	1215085-92-9	99.75%
  GLPG0492 is a non-steroidal selective androgen receptor modulator (potency 12 nM). GLPG0492 has the potential for the research of musculo-skeletal diseases such as sarcopenia and cachexia[1][2].

  

• HY-A0080

  Aminohippurate sodium	94-16-6	99.96%
  Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.

  

• HY-B0903

  Hexylene glycol	107-41-5
  Hexylene glycol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.

  

• HY-B0928

  Homosalate	118-56-9
  Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.

  

• HY-B1991

  Terbutryn	886-50-0	98.88%
  Terbutryn is a selective herbicide and a triazine compound.

  

• HY-B2111

  (R)-(+)-Atenolol	56715-13-0
  (R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist[1][2].

  

• HY-D0723

  5(6)-TAMRA SE	246256-50-8
  5(6)-TAMRA SE is the amine-reactive, mixed isomer form of TAMRA, which is a dye for oligonucleotide labeling and automated DNA sequencing applications.

  

• HY-N0520

  Calycosin-7-O-β-D-glucoside	20633-67-4	98.81%
  Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects[1][2].

  

• HY-13995A

  Sevelamer hydrochloride	152751-57-0
  Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3].

  

• HY-B1092A

  Gluconate sodium	527-07-1
  Gluconate sodium (D-Gluconic acid sodium salt) is a corrosion and scale inhibitor of ordinary steel in simulated cooling water.

  

• HY-W011824

  2′-O-Methyluridine	2140-76-3
  2'-O-methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea, Bacteria, and Eukaryota[1].

  

• HY-W012944

  2-Methylcyclopentane-1,3-dione	765-69-5
  2-Methylcyclopentane-1,3-dione is a key intermediate for the total synthesis of steroids[1].

  

• HY-17530

  Aldicarb sulfone	1646-88-4
  Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.

  

• HY-17614

  Ezutromid	945531-77-1	98.94%
  Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM[1][2].

  

• HY-B0421S

  Mycophenolic acid-d3	1185242-90-3
  Mycophenolic acid-d3 is deuterium labeled Mycophenolic acid, which is an an immunosuppresant drug and has potent anti-proliferative activity.

  

• HY-D0022

  5-Aminofluorescein	3326-34-9
  5-Aminofluorescein (5-AF) is a fluorescence marker, covalently bound to human serum albumin. The excitation wavelength is 490 nm and the emission wavelength is 515 nm.

  

• HY-107846

  Xylan	9014-63-5
  Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose[1].

  

• HY-D0785

  NBD-F	29270-56-2
  NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent which is developed for amino acid analysis. NBD-F reacts with primary or secondary amines to produce a fluorescent product and used for analysis of amino acids and low molecular weight amines[1].

  

• HY-12779

  Cyantraniliprole	736994-63-1	99.83%
  Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.

  

• HY-15908

  BCA	979-88-4
  BCA is 2,2-Biquinoline-4,4-dicarboxylic acid disodium salt; Determination of Cu and protein assay.

  

• HY-41051

  (2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid	45170-31-8
  (2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid is a valine derivative[1].

  

• HY-76082

  L-Pyroglutamic acid	98-79-3
  L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.

  

• HY-79106

  L-Biphenylalanine	155760-02-4	99.95%
  L-Biphenylalanine is a phenylalanine derivative[1].

  

• HY-B2054

  Tebufenozide	112410-23-8	98.91%
  Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells[1][2].

  

• HY-D0211

  Phenolphthalein	77-09-8
  Phenolphthalein is a widely applied but toxic indicator dye.

  

• HY-D0342

  Disperse Red 1	2872-52-8
  Disperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry[1][2].

  

• HY-D0827

  Cy2	260430-02-2
  Cyanines are formally compounds with two nitrogen atoms linked by an odd number of methene units. 26 28 The nitrogen atoms are parts of the heterocyclic units (such as indole, benzoxazol, or benzothiazol) . The structures and optical properties of representative cyanine dyes used for in vivo imaging are presented[1]. Cyanines are characterized by long wavelength, tunable absorption and emission, very high extinction coefficient (up to 300,000 M 1 cm 1), good water solubility, and relatively straightforward synthesis[2].

  

• HY-D0995

  7-Methyl-6-thioguanosine	55727-10-1
  7-Methyl-6-thioguanosine (MESG) is a chromophoric substrate which can be used for the quantitation of inorganic phosphate. 7-Methyl-6-thioguanosine is also used to determine the activity of purine nucleoside phosphorylase[1][2].

  

• HY-I0736

  Isonicotinic acid	55-22-1
  Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[1].

  

• HY-N0130

  Shikimic acid	138-59-0	99.15%
  Shikimic acid is a key metabolic intermediate of the aromatic amino acid biosynthesis pathway, found in microbes and plants.

  

• HY-N0483

  Phillygenin	487-39-8
  Phillygenin (Phillygenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.

  

• HY-N2176

  S-(+)-Marmesin	13849-08-6	99.11%
  S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

  

• HY-N2598

  Methyl oleate	112-62-9
  Methyl oleate is a fatty acid methyl ester (FAME). Methyl oleate substantially improves the antioxidation ability but markedly impaired the antiwear capacity of zinc dialkyldithiophosphate (ZDDP)[1].

  

• HY-N6996

  Methyl Eugenol	93-15-2	98.64%
  Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly[1].

  

• HY-N7064

  Iminostilbene	256-96-2	99.34%
  Iminostilbene is a a chemical precursor of carbamazepine[1].

  

• HY-P1037

  Motilin (26-47), human, porcine	52906-92-0	98.11%
  Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

  

• HY-Z0283

  Benzamide	55-21-0	98.27%
  Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

  

• HY-101075

  L-690330	142523-38-4
  L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase[1].

  

• HY-103615

  Thalidomide-O-amido-C4-N3	2098488-36-7	98.63%
  Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

  

• HY-107368

  Sulcotrione	99105-77-8	99.37%
  Sulcotrione is a β-triketone herbicide which can inhibit hydroxyphenylpyruvate dioxygenase (HPPD).

  

• HY-107829

  3-Aminopropionitrile fumarate (2:1)	2079-89-2
  3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

  

• HY-108690

  Fluxametamide	928783-29-3	98.66%
  Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.

  

• HY-110135

  NBI-31772	374620-70-9	98.99%
  NBI-31772 is the potent and nonselective inhibitor of IGFBP with a Ki value of 47 nM. NBI-31772 has the potential for the research of IGF-responsive diseases[1].

  

• HY-112531

  Poly(2-hydroxyethyl methacrylate) (MW 20000)	25249-16-5
  Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of drug and etc[1].

  

• HY-112679

  GLP-1 receptor agonist 2	2230197-64-3	98.70%
  GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist.

  

• HY-112843

  CNT2 inhibitor-1	880155-70-4	98.77%
  CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

  

• HY-113047

  5,6-Dihydrouridine	5627-05-4	99.90%
  5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

  

• HY-113306

  1-Methyladenine	5142-22-3
  1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

  

• HY-117695

  AQC	148757-94-2
  AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels[1][2].

  

• HY-125864

  Fibrinogen (Bovine)	9001-32-5
  Fibrinogen (Bovine) is a selectively proteolyzed molecule and its thrombin-activated assembly into the fibrin clot[1].

  

• HY-126741

  Azadirachtin	11141-17-6	98.05%
  Azadirachtin, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4[1].

  

• HY-130013

  HKYellow-AM (6/12-mixture)	1448821-89-3	98.69%
  HKYellow-AM (6/12-mixture) is a yellow fluorescent probe that can detect ONOO- in living cells and tissues with high selectivity and sensitivity without cytotoxicity[2].

  

• HY-131113

  N-Nitrosodibutylamine	924-16-3
  N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water[1].

  

• HY-131943

  DS44960156	2361327-08-2
  DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values