1. Neuronal Signaling
  2. AChE

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-76299
    Galanthamine Inhibitor
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 500 nM.
  • HY-B0034
    Donepezil Hydrochloride Inhibitor
    Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine.
  • HY-17552
    sn-Glycero-3-phosphocholine Activator
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and
  • HY-17368
    Rivastigmine Inhibitor
    Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.
  • HY-B0942
    Benzethonium chloride Inhibitor
    Benzethonium chloride inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes.
  • HY-16009
    (+)-PHENSERINE Inhibitor
    Posiphen is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.
  • HY-110389
    Pitofenone hydrochloride Inhibitor
    Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.
  • HY-A0009
    Galanthamine hydrobromide Inhibitor
    Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
  • HY-17388
    (±)-Huperzine A Inhibitor
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-17387
    (-)-Huperzine A Inhibitor
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
  • HY-N0342
    Scopoletin Inhibitor
    Scopoletin is an inhibitor of acetylcholinesterase (AChE).
  • HY-N0226A
    Epiberberine chloride Inhibitor
    Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
  • HY-B1200
    Pralidoxime chloride Activator
    Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning.
  • HY-B0732
    Itopride hydrochloride Inhibitor
    Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.
  • HY-B0882
    Edrophonium chloride Inhibitor
    Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
  • HY-N0285
    Imperatorin Inhibitor
    Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
  • HY-14566
    Donepezil Inhibitor
    Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
  • HY-B0207A
    Pyridostigmine bromide Inhibitor
    Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.
  • HY-I0020
    Galanthaminone Inhibitor
    Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
  • HY-B0949
    Protriptyline hydrochloride Inhibitor
    Protriptyline is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.