1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

AMPK Related Products (27):

Cat. No. Product Name Effect Purity
  • HY-17471A
    Metformin hydrochloride Activator 99.98%
    Metformin (hydrochloride) is an FDA approved first-line drug for the treatment of type 2 diabetes. Metformin decreases hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory-chain complex 1.
  • HY-13418
    Dorsomorphin dihydrochloride Inhibitor 99.73%
    Dorsomorphin dihydrochloride (BML-275 dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109±16 nM.
  • HY-13417
    AICAR Activator 99.92%
    AICAR is a cell-permeable AMP-activated protein kinase (AMPK) activator.
  • HY-13418A
    Dorsomorphin Inhibitor 99.65%
    Dorsomorphin is a potent and selective AMPK inhibitor, that is competitive with ATP, with Ki=109±16 nM in the absence of AMP.
  • HY-50662
    A-769662 Activator 98.09%
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
  • HY-111363
    MK8722 Activator
    MK8722 is a potent and systemic pan-AMPK activator.
  • HY-16397A
    Phenformin hydrochloride Activator 98.17%
    Phenformin (hydrochloride) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-13417A
    AICAR phosphate Activator >98.0%
    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-12357
    ETC-1002 Activator >98.0%
    ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK).
  • HY-B1221
    Flufenamic acid Activator 99.92%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels.
  • HY-15802
    WZ4003 Inhibitor
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1/NUAK2, without significant inhibition on other 139 kinases.
  • HY-103683
    PF-06409577 Activator 98.56%
    PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
  • HY-112233
    O-304 Activator 98.63%
    O-304 is a small molecule AMPK activator.
  • HY-B0923
    Danthron Activator >98.0%
    Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
  • HY-16708A
    ZLN024 hydrochloride Activator 98.55%
    ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-12334
    HTH-01-015 Inhibitor 99.19%
    HTH-01-015 is a selective NUAK1 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
  • HY-15840
    YLF-466D Activator 99.16%
    YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.
  • HY-12831
    Ampkinone Activator 99.31%
    Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
  • HY-N2341
    Palmitelaidic Acid Activator 98.00%
    Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.