1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

ATM/ATR

ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.

ATM/ATR Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-10197
    Wortmannin Inhibitor 99.65%
    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 200 nM, respectively. Wortmannin is also a potent inhibitor of DNA-PK (IC50, 16 nM) and ATM (IC50, 150 nM). Wortmannin is also a potent inhibitor of Polo-like kinase (Plk).
  • HY-19323
    AZD6738 Inhibitor 99.76%
    AZD6738 is a potent inhibitor of ATR kinase with an IC50 of 1 nM.
  • HY-13902
    VE-822 Inhibitor 99.22%
    VE-822 is an ATR inhibitor with Ki value of <0.2 nM, also inhibits ATM with Ki of 34 nM.
  • HY-12016
    KU-55933 Inhibitor 99.67%
    KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
  • HY-14731
    VE-821 Inhibitor 99.47%
    VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
  • HY-112305
    AZ32 Inhibitor
    AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
  • HY-18650
    KU 59403 Inhibitor
    KU 59403 is a potent ATM inhibitor, with an IC50 of 3 nM.
  • HY-100016
    AZD0156 Inhibitor 99.60%
    AZD0156 is an orally active, potent and selective ATM kinase inhibitor, used for cancer research.
  • HY-12061
    KU-60019 Inhibitor 98.03%
    KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
  • HY-15557
    AZ20 Inhibitor 99.84%
    AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).
  • HY-11002
    CP-466722 Inhibitor 98.40%
    CP-466722 is a rapidly reversible inhibitor of ATM, with an IC50 of 4.1 μM, and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.
  • HY-109566
    AZD1390 Inhibitor 99.81%
    AZD1390 is an ATM inhibitor.
  • HY-101566A
    BAY-1895344 hydrochloride Inhibitor 99.04%
    BAY-1895344 hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM.
  • HY-15520
    CGK733 Inhibitor 99.93%
    CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
  • HY-15521
    ETP-46464 Inhibitor 99.13%
    ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively.