2. GPCR/G Protein
  3. Adenosine Receptor

Adenosine Receptor

Adenosine Receptor

Related Products

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Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (46):

Cat. No. Product Name Effect Purity
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 99.70%
    CGS 21680 Hydrochloride is a specific adenosine A2A receptor agonist, used for treatment of neurological disease.
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.
  • HY-10889
    Preladenant Antagonist 99.08%
    Preladenant is a potent competitive antagonist of the human A2A receptor (Ki=1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
  • HY-B0809
    Theophylline Inhibitor 99.94%
    Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
  • HY-19533
    SCH 58261 Antagonist 99.38%
    SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
  • HY-19661
    Tecadenoson Agonist 99.64%
    Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.
  • HY-10857
    Vipadenant Antagonist 98.28%
    Vipadenant is an adenosine receptor antagonist, with Ki of 1.3 nM and 68 nM for A2A and A1, respectively.
  • HY-10888
    Istradefylline Antagonist 99.42%
    Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
  • HY-101978
    CPI-444 Inhibitor 99.85%
    CPI-444 is a potent and selective inhibitor of A2A receptor (A2AR) induces antitumor responses.
  • HY-10995
    Tozadenant Antagonist 98.06%
    Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
  • HY-14917
    Capadenoson Agonist 98.43%
    Capadenoson is a selective agonist of adenosine-A1 receptor.
  • HY-12365
    2-Cl-IB-MECA Agonist 99.51%
    2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM).
  • HY-A0168
    Regadenoson Agonist >98.0%
    Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.99%
    Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
  • HY-13591
    IB-MECA Agonist 98.97%
    IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.
  • HY-103173
    NECA Agonist 99.86%
    NECA is a nonselective adenosine receptor agonist.
  • HY-101980
    AZD4635 Inhibitor 99.79%
    AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.
  • HY-18939
    N6-Cyclohexyladenosine Agonist 99.98%
    N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
  • HY-100747
    PSB-12379 Inhibitor 99.54%
    PSB-12379 is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
  • HY-B0128
    Diphylline Antagonist 99.28%
    Dyphylline acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.