Adenosine Receptor

Related Products

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (46):

By Effects:	Inhibitors (9) Agonists (18) Antagonists (18)

Cat. No.	Product Name	Effect	Purity

HY-10889

Preladenant	Antagonist	99.08%
Preladenant is a potent competitive antagonist of the human A_2A receptor (K_i=1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.

HY-19532

ZM241385	Antagonist	98.55%
ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.

HY-13201A

CGS 21680 Hydrochloride	Agonist	99.70%
CGS 21680 Hydrochloride is a specific adenosine A2A receptor agonist, used for treatment of neurological disease.

HY-10857

Vipadenant	Antagonist	98.28%
Vipadenant is an adenosine receptor antagonist, with K_i of 1.3 nM and 68 nM for A_2A and A₁, respectively.

HY-19533

SCH 58261	Antagonist	99.38%
SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.

HY-19661

Tecadenoson	Agonist	99.64%
Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist.

HY-100274

Adenosine antagonist-1	Antagonist
Adenosine antagonist-1 is an adenosine A3 receptor (AA3R) antagonist.

HY-103695

CD73-IN-1	Inhibitor	98.78%
CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.

HY-B0809

Theophylline	Inhibitor	99.94%
Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.

HY-10888

Istradefylline	Antagonist	99.42%
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with K_i of 2.2 nM in experimental models of Parkinson's disease.

HY-10995

Tozadenant	Antagonist	98.06%
Tozadenant is an adenosine A_2A receptor antagonist, with K_i of 11.5 nM on human A_2A and 6 nM on rhesus A_2A.

HY-14917

Capadenoson	Agonist	98.43%
Capadenoson is a selective agonist of adenosine-A1 receptor.

HY-A0168

Regadenoson	Agonist	>98.0%
Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.

HY-101978

CPI-444	Inhibitor	99.85%
CPI-444 is a potent and selective inhibitor of A2A receptor (A2AR) induces antitumor responses.

HY-12365

2-Cl-IB-MECA	Agonist	99.51%
2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM).

HY-13591

IB-MECA	Agonist	98.97%
IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.

HY-B0153A

Ticlopidine hydrochloride	Inhibitor	99.99%
Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.

HY-18939

N6-Cyclohexyladenosine	Agonist	>98.0%
N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).

HY-101980

AZD4635	Inhibitor	99.79%
AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a K_i of 1.7 nM.

HY-100747

PSB-12379	Inhibitor	99.54%
PSB-12379 is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with K_is of 9.03 nM (rat) and 2.21 nM (human).