1. Metabolic Enzyme/Protease
  2. Aldose Reductase

Aldose Reductase

Aldose reductase is an NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. The aldose reductase reaction, in particular the sorbitol produced, is important for the function of various organs in the body. Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes.

Aldose Reductase Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-N0102
    Isoliquiritigenin Inhibitor 98.24%
    Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.
  • HY-66009
    Epalrestat Inhibitor >98.0%
    Epalrestat is an aldose reductase inhibitor for the treatment of diabetic neuropathy.
  • HY-16500
    Tolrestat Inhibitor 98.85%
    Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
  • HY-15314
    Ranirestat Inhibitor 99.14%
    Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
  • HY-B1202
    Alrestatin Inhibitor 99.14%
    Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
  • HY-105185
    Fidarestat Inhibitor
    Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat has the potential to treat diabetic disease.
  • HY-18967
    Aldose reductase-IN-1 Inhibitor 99.86%
    Aldose reductase-IN-1 is a inhibitor of aldose reductase with IC50 of 28.9 pM.
  • HY-16255
    IMIRESTAT Inhibitor 99.52%
    IMIRESTAT is an aldose reductase inhibitor, used for the treatment of diabetes.
  • HY-16433
    RISARESTAT Inhibitor
    RISARESTAT (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.
  • HY-B1202A
    Alrestatin sodium Inhibitor
    Alrestatin sodium is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.