1. Neuronal Signaling
  2. Amyloid-β

Amyloid-β

Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.

Amyloid-β Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-B0988
    Deferoxamine mesylate Inhibitor
    Deferoxamine mesylate is an iron chelator, and effectively reduces oxidative stress and neuronal death.
  • HY-19370
    FPS-ZM1 Inhibitor
    FPS-ZM1 is a high-affinity RAGE specific inhibitor with a Ki of 25 nM.
  • HY-P0128
    Amyloid beta-peptide(25-35)
    Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-N0009
    Geniposide Antagonist
    Geniposide is an iridoid glucoside extracted from Gardenia jasminoides Ellis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
  • HY-P1567
    β-Amyloid (10-35), amide
    β-Amyloid (10-35), amide is a 26-aa peptide, comprising residues 10-35 of the Aβ peptide. β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques,
  • HY-P1061
    Colivelin
    Colivelin is a neuroprotective peptide and activator of STAT3.
  • HY-P1524
    Beta-Amyloid(1-14),mouse,rat
    Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
  • HY-N0045
    Ginsenoside Rg1 Inhibitor
    Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
  • HY-10009
    Semagacestat Inhibitor
    Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.
  • HY-14537
    Latrepirdine dihydrochloride Inhibitor
    Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β () secretion.
  • HY-17631A
    Edonerpic maleate Inhibitor
    Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides ().
  • HY-15560B
    Hoechst 34580 tetrahydrochloride Inhibitor
    Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei.
  • HY-P1363
    Amyloid β-Peptide (1-42) human
    Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
  • HY-N0044
    Ginsenoside Re Inhibitor
    Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.
  • HY-N0615
    Notoginsenoside R1 Inhibitor
    Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported have some neuronal protective, antihypertensive effects.
  • HY-14602
    Tramiprosate Inhibitor
    Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition.
  • HY-N0602
    Ginsenoside Rg2 Inhibitor
    Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 acts as a NF-κB inhibitor. Ginsenoside Rg2 also reduces 1-42 accumulation.
  • HY-15374
    Frentizole Inhibitor
    Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.
  • HY-111383
    LX2343 Inhibitor
    LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of clearance.