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Androgen Receptor

Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).

Androgen Receptor Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-70002
    Enzalutamide Antagonist 99.18%
    Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
  • HY-16060
    ARN-509 Antagonist 99.23%
    ARN-509 is a potent and competitive androgen receptor (AR) antagonist, binds AR with IC50 of 16 nM.
  • HY-14249
    Bicalutamide Agonist 99.61%
    Bicalutamide(Casodex) is an oral non-steroidal anti-androgen for prostate cancer; binds to the androgen receptor.
  • HY-16985
    ODM-201 Antagonist 98.01%
    ODM-201 is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in AR-HEK293 cells.
  • HY-14650
    DHEA Inhibitor >98.0%
    DHEA is an important source of androgens, and is an effective antiapoptotic factor.
  • HY-109619
    D4-abiraterone Antagonist
    D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.
  • HY-N0790
    Lupeol Inhibitor >98.0%
    Lupeol is a novel androgen receptor inhibitor.
  • HY-17434
    Boldenone Undecylenate Agonist
    Boldenone undecylenate(Equipoise) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans.
  • HY-15194
    ASC-J9 Inhibitor 98.06%
    ASC-J9 is antitumor agent, suppressesing castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors.
  • HY-B0022
    Flutamide Antagonist 99.01%
    Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
  • HY-B0561
    Spironolactone Antagonist
    Spironolactone is a potent antagonist of the androgen receptor.
  • HY-11027
    MK-0773 Inhibitor 99.48%
    MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.
  • HY-B1269
    Testosterone propionate Agonist 99.90%
    Testosterone Propionate is an efficient androgenic hormone for the treatment of low testosterone.
  • HY-15758
    3,3'-Diindolylmethane Antagonist 98.74%
    3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
  • HY-18102
    GLPG0492 Modulator
    GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
  • HY-16079
    AZD3514 Inhibitor 98.15%
    AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.
  • HY-70002A
    N-desmethyl Enzalutamide 99.14%
    N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.
  • HY-B0626
    Testosterone undecanoate Agonist >98.0%
    Testosterone undecanoate is an ester of testosterone; used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
  • HY-13604
    Cyproterone acetate Antagonist 99.71%
    Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.
  • HY-B1029
    Danazol Agonist 98.28%
    Danazol is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects.