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Aromatase

Aromatase (estrogen synthetase, CYP19) is a member of cytochrome P450 and the only known enzyme catalyzes the biogenesis of estrogens through the aromatization of androgens. For its roles in reproduction system, aromatase is a famous target for inhibitor therapy in estrogen-sensitive diseases including breast cancer, endometriosis, leiomyoma, etc.

Aromatase inhibitors (AIs) are drugs that deplete the levels of estrogens by inhibiting aromatase. AIs can be divided in two types according to their chemical structure, steroidal (Type I) and non-steroidal (type II). AIs can also be grouped in three generations based their chronological order of appearance in clinic. The first-generation AI is aminoglutethimide, the second-generation inhibitors include imidazole, fadrozole and formestane, while the third-generation inhibitors are anastrozole, letrozole, and exemestane.

Aromatase Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-14248
    Letrozole Inhibitor 99.92%
    Letrozole is an orally active aromatase inhibitor with an IC50 of 1-13 nM.
  • HY-14274
    Anastrozole Inhibitor 99.93%
    Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
  • HY-13632
    Exemestane Inhibitor 99.95%
    Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.
  • HY-18719B
    Endoxifen hydrochloride 98.32%
    Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].
  • HY-14247
    Fadrozole hydrochloride Inhibitor 99.64%
    Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
  • HY-136092
    Androsta-1,4,6-triene-3,17-dione Inhibitor
    Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].
  • HY-U00176
    Org30958 Inhibitor
    Org30958 is a potent aromatase inhibitor in vivo.
  • HY-14247A
    Fadrozole Inhibitor 99.78%
    Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
  • HY-N0292
    Oleuropein Inhibitor 98.54%
    Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase[2].
  • HY-18719E
    Endoxifen
    Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].
  • HY-125833
    Alpha-Naphthoflavone Inhibitor 98.02%
    Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively[1].