1. Immunology/Inflammation
  2. COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Related Products (111):

Cat. No. Product Name Effect Purity
  • HY-14398
    Celecoxib Inhibitor 99.65%
    Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.
  • HY-66005
    Acetaminophen Inhibitor 99.69%
    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug.
  • HY-14397
    Indomethacin Inhibitor >98.0%
    Indomethacin is a nonselective inhibitor of COX1 and COX2, used to reduce fever, pain, stiffness, and swelling.
  • HY-14654
    Aspirin Inhibitor >99.0%
    Aspirin (acetylsalicylic acid ) is an inhibitor of COX-1 with an IC50 of 5 μg/mL; commonly used for the treatment of pain, fever, and inflammation.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-19675
    Naproxen etemesil Inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay.
  • HY-18342
    Diflunisal Inhibitor 99.37%
    Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
  • HY-111354
    Tinoridine hydrochloride Inhibitor 98.07%
    Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.
  • HY-N0904
    Ginsenoside C-K Inhibitor 98.06%
    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.
  • HY-14617
    Paradol Inhibitor 98.84%
    Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
  • HY-17372
    Rofecoxib Inhibitor 99.95%
    Rofecoxib(MK 966) is a potent inhibitor of the COX-2-dependent production of PGE2 in human osteosarcoma cells (IC50= 26±10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC50=18±7 nM).
  • HY-13913
    NS-398 Inhibitor 99.79%
    NS-398 is a COX-2 inhibitor. The COX-1 activity is completely unaffected by 100 μM NS-398, whereas the COX-2 activity was concentration-dependently inhibited, the IC50 value being 3.8 μM.
  • HY-15036
    Diclofenac Inhibitor 99.53%
    Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
  • HY-N1067
    Xanthohumol Inhibitor 99.68%
    Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities.
  • HY-B0261
    Meloxicam Inhibitor 98.07%
    Meloxicam is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects.
  • HY-78131
    Ibuprofen Inhibitor 99.99%
    Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
  • HY-B1221
    Flufenamic acid Inhibitor 99.92%
    Flufenamic acid is a member of the NSAID drugs, is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6.
  • HY-B1227
    Carprofen Inhibitor 99.76%
    Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins, does not interfere with COX-1 activity.
  • HY-15037
    Diclofenac Sodium Inhibitor >98.0%
    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
  • HY-17009
    Iguratimod Inhibitor 99.85%
    Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.