1. Apoptosis
  2. Caspase

Caspase

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Caspase Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-16658
    Z-VAD(OMe)-FMK Inhibitor >98.0%
    Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.
  • HY-13205
    VX-765 Inhibitor 99.99%
    VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor, inhibits IL-1β release with similar potency in PBMCs from FCAS (IC50=0.99±0.29 μM) and control (IC50=1.1±0.61 μM) subjects.
  • HY-12466
    Z-DEVD-FMK Inhibitor >98.0%
    Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with IC50 of 18 μM.
  • HY-12305
    Q-VD-OPh Inhibitor 99.26%
    Q-VD-OPha is a irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPha is able to cross the blood-brain barrier.
  • HY-101297
    Z-IETD-FMK Inhibitor >98.0%
    Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor.
  • HY-19696
    Tauroursodeoxycholate Inhibitor
    Tauroursodeoxycholate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
  • HY-N1157
    Thevetiaflavone Inhibitor
    Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3.
  • HY-12412
    ML132 Inhibitor
    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.
  • HY-19696A
    Tauroursodeoxycholate Sodium Inhibitor >98.0%
    Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
  • HY-P1001
    Ac-DEVD-CHO Inhibitor 98.84%
    Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM. Sequence: N-Acetyl-Asp-Glu-Val-Asp-al.
  • HY-13523
    PAC-1 Activator
    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
  • HY-13229
    BOC-D-FMK Inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-N0605
    Ginsenoside Rh2 Activator >98.0%
    Ginsenoside Rh2 is isolated from the root of Ginseng. Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.
  • HY-103667
    2-HBA Activator 98.83%
    2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
  • HY-10397
    EP1013 Inhibitor
    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
  • HY-100894
    Biotin-VAD-FMK Inhibitor >98.0%
    Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.
  • HY-N0905
    Ginsenoside Rh4 Activator 98.40%
    Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.