1. Metabolic Enzyme/Protease
  2. Cathepsin

Cathepsin

Cathepsins are proteases (enzymes that degrades proteins) found in all animals as well as other organisms. The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. Most of the members become activated at the low pH found in lysosomes. The activity of this family lies almost entirely within those organelles. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substratespecificities. Classification: Cathepsin A, Cathepsin B, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin F, Cathepsin G, Cathepsin H, Cathepsin K, Cathepsin L1, Cathepsin L2, Cathepsin O, Cathepsin S, Cathepsin W, Cathepsin Z. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides.

Cathepsin Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-100229
    Aloxistatin Inhibitor 98.22%
    Aloxistatin (E64d) is a broad-spectrum cell-permeable cysteine protease inhibitor.
  • HY-18234A
    Leupeptin hemisulfate Inhibitor >98.0%
    Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin.
  • HY-15282
    E-64 Inhibitor 99.62%
    E-64 is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
  • HY-100350
    CA-074 methyl ester Inhibitor 98.40%
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
  • HY-10042
    Odanacatib Inhibitor 99.80%
    Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrates high selectivity versus off-target cathepsin B, L, S.
  • HY-112583
    MIV-247 Inhibitor
    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
  • HY-15533
    LY 3000328 Inhibitor 98.62%
    LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S.
  • HY-15958
    VBY-825 Inhibitor >98.0%
    VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
  • HY-103350
    CA-074 Inhibitor 98.92%
    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
  • HY-15100
    Balicatib Inhibitor
    Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.
  • HY-50887
    MK-0822 Inhibitor
    MK-0822 is an orally active, selective, and reversible cathepsin K inhibitor, used for treatment of post-menopausal osteoporosis.
  • HY-U00377
    Cathepsin Inhibitor 2 Inhibitor
    Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.