1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Related Products (54):

Cat. No. Product Name Effect Purity
  • HY-14531
    Talarozole Inhibitor 99.54%
    Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50 of 0.46 nM and 5.1 nM for CYP26B1 and CYP26A1, respectively.
  • HY-75054
    Abiraterone acetate Inhibitor 99.92%
    Abiraterone acetate is an oral, potent, selective, and irreversible inhibitor of CYP17.
  • HY-12451
    FICZ 98.19%
    FICZ is a potent aryl hydrocarbon receptor (AHR) agonist, and also has the qualities of a perfect substrate for mammalian CYP1 enzymes.
  • HY-70013
    Abiraterone Inhibitor 99.61%
    Abiraterone is a potent, selective, and irreversible CYP17 inhibitor with IC50 of 2 to 4 nM.
  • HY-17356
    Fenofibrate Inhibitor 99.92%
    Fenofibrate is a relatively potent inhibitor of CYP2C19 (IC50=0.2 μM) and CYP2B6 (IC50=0.7 μM). Fenofibrate is also a well-known PPARα agonist (EC50=30 μM).
  • HY-12433
    BMS-819881 Inhibitor
    BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM.
  • HY-100238
    Antihistamine-1 Inhibitor
    Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM.
  • HY-111430
    1-Ethynylnaphthalene Inhibitor 98.76%
    1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
  • HY-10493
    Cobicistat Inhibitor >98.0%
    Cobicistat is a potent, and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50 of 30-285 nM.
  • HY-N1201
    Apigenin Inhibitor >98.0%
    Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-B0258
    Gemfibrozil Inhibitor 99.91%
    Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
  • HY-70006
    TOK-001 Inhibitor 99.14%
    TOK-001 is a multifunctional antiandrogen and CYP17 inhibitor (IC50=47 nM) in castration resistant prostate cancer (CRPC).
  • HY-17508
    Clarithromycin Inhibitor >98.0%
    Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.
  • HY-N0153
    Naringin Inhibitor 99.50%
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.
  • HY-76316
    Bergaptol Inhibitor 99.28%
    Bergaptol A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
  • HY-B1311
    Proadifen hydrochloride Inhibitor >98.0%
    Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM).
  • HY-10505
    Orteronel Inhibitor 99.75%
    Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4.