1. Protein Tyrosine Kinase/RTK
  2. DYRK

DYRK

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

DYRK Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-N0737A
    Harmine Inhibitor 99.58%
    Harmine, an inhibitor of DYRK1A and 5-HT2A, with a Ki of 397 nM for 5-HT2A, could also negatively regulate HR by interfering Rad51 recruitment.
  • HY-12277
    AZ191 Inhibitor 99.63%
    AZ191 is a potent small molecule inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM; selective for DYRK1B over both DYRK1A and DYRK2.
  • HY-12838
    Mirk-IN-1 Inhibitor 99.53%
    Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively.
  • HY-15838
    ID-8 Inhibitor >98.0%
    ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
  • HY-U00439
    Protein kinase inhibitors 1 Inhibitor >99.0%
    Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
  • HY-111380
    EHT 5372 Inhibitor
    EHT 5372 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively.
  • HY-U00439A
    Protein kinase inhibitors 1 hydrochloride Inhibitor >98.0%
    Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2.