1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Eukaryotic Initiation Factor (eIF) Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-13251
    Silvestrol Inhibitor 99.28%
    Silvestrol is isolated from the fruits and twigs of Aglaia foveolata, and is a specific eIF4A-targeting translation inhibitor.
  • HY-19831
    4EGI-1 Inhibitor >98.0%
    4EGI-1 is an inhibitor of eIF4E/eIF4G interaction, with a Kd of 25 μM against eIF4E binding.
  • HY-14427
    4E1RCat Inhibitor 98.20%
    4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM.
  • HY-100733
    4E2RCat Inhibitor >98.0%
    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
  • HY-16366
    Briciclib Inhibitor 99.15%
    Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
  • HY-19560
    SBI-0640756 Inhibitor >98.0%
    SBI-0640756 is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex.
  • HY-15359
    Episilvestrol Inhibitor
    Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.