1. Cytoskeleton
  2. Gap Junction Protein

Gap Junction Protein

Gap junction channels are essential in normal heart function and they assist in the mediated spread of electrical impulses that stimulate synchronized contraction (via an electrical syncytium) of cardiac tissues.

Gap junction (GJ) proteins play an important role in direct communication between cells of many tissue types. GJs are specialised intercellular membrane-spanning domains that allow the passage of small molecules including second messenger (e.g. c-AMP, inositol triphosphate) or ionic signals from one cell to another. GJ proteins and their long evolutionary history have permitted adaptation of gap junction intercellular communication (GJIC) with several important functions and multiple regulatory processes. Formation of GJIC is an essential mechanism in coordinating growth and development and tissue compartmentalization during embryonic development.

Gap Junction Protein Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-15204
    Tonabersat Modulator 98.48%
    Tonabersat is a gap-junction modulator.
  • HY-P0139
    Gap 27 Inhibitor 98.34%
    Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor. Sequence: Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile.
  • HY-10913
    Danegaptide Modulator
    GAP-134 (Danegaptide, ZP 1609), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
  • HY-P1082
    Gap 26 Inhibitor 99.30%
    Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.