2. Cytoskeleton
  3. Gap Junction Protein

Gap Junction Protein

Gap junction (GJ) channels span the plasma membranes of adjacent cells and are formed by the docking of two hemichannels (connexons) oligomerized from connexin (Cx) proteins, which consist of 21 distinct isoforms. GJs provide a direct pathway for cell-to-cell electrical signaling and metabolic communication, allowing the passage of small ions, amino acids, metabolites, tetraethylammonium and signaling molecules such as cAMP, IP3, siRNA and small peptide.

Gap junction channels provide the basis for intercellular communication in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone and endothelial function as well as metabolic interchange between the cells. In the heart, GJs mediate electrical coupling between cardiac myocytes, forming the cell-to-cell pathways for orderly spread of the wave of electrical excitation responsible for synchronous contraction. Gap junctions also play an important role in the control of bladder contractile response and in the regulation of various immune inflammatory processes.

Gap Junction Protein Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-B1320
    Meclofenamic acid sodium Inhibitor 99.89%
    Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities[1][2][3].
  • HY-P0139
    Gap 27 Inhibitor 99.51%
    Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment[1][2].
  • HY-10913A
    Danegaptide Hydrochloride Modulator 99.49%
    Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
  • HY-106268A
    Larazotide acetate Inhibitor
    Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.
  • HY-B1367
    Carbenoxolone disodium Inhibitor 99.94%
    Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD[1]. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication[2]. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.
  • HY-106225R
    Rotigaptide (Standard) Activator
    Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation[1][2].
  • HY-15204S
    Tonabersat-d6 Modulator
    Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].
  • HY-10913S
    Danegaptide-d5 Modulator
    Danegaptide-d5 (GAP-134-d5) is deuterium labeled Danegaptide. Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
  • HY-P9991
    Osemitamab Inhibitor 99.43%
    Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study[1][2].
  • HY-P1136B
    TAT-Gap19 99.47%
    TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3].
  • HY-149318
    VRT-534
    VRT-534 targets connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50 value of 19 μM and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].
  • HY-114426
    AT-1002 Modulator
    AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].
  • HY-14584A
    PQ-1 succinate Inhibitor
    PQ-1 succinate is an inhibitor for gap junction, which suppresses the gap junction dye transfer activity in retinal neurosensory R28 cells, and inhibits the CoCl2-induced ischemic apoptosis in retinal cell[1].
  • HY-P1138
    Scrambled 10Panx Inhibitor
    Scrambled 10Panx (FSVYWAQADR) is a random sequence variant of a specific inhibitory peptide 10Panx targeted at the half-channel of Pannexin-1 (Panx1). Scrambled 10Panx is used as a control peptide to determine whether other experimental conditions or peptides act through specific molecular mechanisms. Scrambled 10Panx can be used for research in neurobiology and cell biology[1].
  • HY-P2275
    Peptide5 Inhibitor 98.39%
    Peptide5, a connexin 43 mimetic peptide, reduce animals swelling, astrogliosis, and neuronal cell death after spinal cord injury[1]
  • HY-153833
    PDS-0330 99.77%
    PDS-0330 is a specific and potent Claudin-1 inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis[1].
  • HY-163905
    EG-2184 Inhibitor 99.50%
    EG-2184 is a Pannexin-1 channel inhibitor. EG-2184 can be used in opioid withdrawal related research[1].
  • HY-15204
    Tonabersat Modulator 98.36%
    Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].
  • HY-P1136C
    TAT-Gap19 TFA 99.38%
    TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3].
  • HY-P2275B
    Peptide5 TFA Inhibitor
    Peptide5 TFA, a connexin 43 mimetic peptide, reduces animals swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 TFA also inhibits NLRP3 inflammasome, and is an anti-inflammatory agent[1][2][3].