1. GPCR/G Protein
  2. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-N0583
    Hydrocortisone Agonist 99.66%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
  • HY-14648
    Dexamethasone Agonist 98.70%
    Dexamethasone is a glucocorticoid receptor agonist.
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone is a progesterone receptor (PR) antagonist (IC50=0.2 nM) in a T47D cell-based assay, also is a glucocorticoid receptor (GR) antagonist (IC50=2.6 nM) in an A549 cell-based assay.
  • HY-B0214
    Prednisone Agonist 99.13%
    Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
  • HY-17463
    Prednisolone Agonist >98.0%
    Prednisolone is a glucocorticoid with the general properties of the corticosteroids.
  • HY-15710
    Cort108297 Antagonist
    Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.
  • HY-B1829A
    Dexamethasone phosphate disodium Agonist
    Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.
  • HY-B1900
    Methylprednisolone succinate Agonist 99.14%
    Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.
  • HY-13580
    Budesonide Agonist >98.0%
    Budesonide is a glucocorticoid used in the management of asthma.
  • HY-B0154
    Fluticasone propionate Agonist 99.77%
    Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
  • HY-14648A
    Dexamethasone acetate Agonist 99.34%
    Dexamethasone acetate is a glucocorticoid receptor agonist.
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor and a PPARγ activator.
  • HY-B0636
    Triamcinolone acetonide Agonist 99.08%
    Triamcinolone Acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.
  • HY-B0328
    Triamcinolone Inhibitor 99.15%
    Triamcinolone is a long-acting synthetic corticosteroid.
  • HY-13600
    Clobetasol propionate Agonist >98.0%
    Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.
  • HY-17461
    Cortisone Agonist 98.08%
    Cortisone is a 21-carbon steroid hormone. Cortisone is one of the main hormones released by the adrenal gland in response to stress.
  • HY-77839
    Cortodoxone Agonist 99.35%
    Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
  • HY-13570
    Betamethasone Agonist 99.24%
    Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
  • HY-B1121
    Flunisolide Activator 99.61%
    Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.
  • HY-B1183
    Hydrocortisone acetate Agonist 99.07%
    Hydrocortisone acetate is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids.