1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase

Gutathione S-transferase

Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds. GSTs are divided into two distinct super-family members: the membrane-bound microsomal and cytosolic family members. Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. Glutathione S-transferases (GSTs) function to protect cellular macromolecules from attack by reactive electrophiles. GSTs may be viable drug targets in disease states unrelated to cancer.

Gutathione S-transferase Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-13634A
    Ezatiostat Inhibitor
    Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
  • HY-111530
    GSTO1-IN-1 Inhibitor 98.32%
    GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM.
  • HY-13634B
    TLK117 Inhibitor
    TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
  • HY-13634
    Ezatiostat hydrochloride Inhibitor
    Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
  • HY-112534
    GSTO-IN-2 Inhibitor
    GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.