1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase

Gutathione S-transferase

Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds. GSTs are divided into two distinct super-family members: the membrane-bound microsomal and cytosolic family members. Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. Glutathione S-transferases (GSTs) function to protect cellular macromolecules from attack by reactive electrophiles. GSTs may be viable drug targets in disease states unrelated to cancer.

Gutathione S-transferase Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-13634A
    Ezatiostat Inhibitor
    Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
  • HY-13634
    Ezatiostat hydrochloride Inhibitor
    Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).