1. Anti-infection
  2. HIV

HIV

HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV Related Products (87):

Cat. No. Product Name Effect Purity
  • HY-13004
    Maraviroc Inhibitor 99.34%
    Maraviroc is a selective CCR5 antagonist, inhibits MIP-1α (IC50, 3.3 nM), MIP-1β (IC50, 7.2 nM), and RANTES (IC50, 5.2 nM) binding to cell membrane preparations of CCR5-expressing HEK-293.
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir is an inhibitor of HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • HY-14740
    Elvitegravir Inhibitor 99.78%
    Elvitegravir is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.
  • HY-17605
    Bictegravir Inhibitor
    Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
  • HY-107902
    RIG-1 modulator 1 Inhibitor 98.81%
    RIG-1 modulator 1 is an anti-viral compound which can be useful for the treatment of viral infections including influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1.
  • HY-B1408
    Salicylanilide Inhibitor 99.60%
    Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase.
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
  • HY-13782
    Tenofovir Disoproxil Fumarate Inhibitor 99.38%
    Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
  • HY-13685
    Miltefosine Inhibitor >98.0%
    Miltefosine is a PI3K/Akt inhibitor, dramatically reduces HIV-1 production from long-living virus-infected macrophages.
  • HY-10572
    Efavirenz Inhibitor 99.69%
    Efavirenz is a potent inhibitor of the wild-type HIV-1 RT (Ki=2.93 nM) and exhibits IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
  • HY-15148
    Tipranavir Inhibitor 99.54%
    Tipranavir inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM.
  • HY-17427
    Emtricitabine Inhibitor 99.60%
    Emtricitabine is an inhibitor of the nucleoside reverse transcriptase (NRTI) and human immunodeficiency virus type 1 (HIV-1); inhibits NRTI with an EC50 of 0.01 µM in PBMC cell.
  • HY-B0250
    Lamivudine Inhibitor 99.64%
    Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.
  • HY-10571A
    Delavirdine mesylate Inhibitor 98.07%
    Delavirdine(U 90152) mesylate is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).
  • HY-13910
    Tenofovir Inhibitor 99.77%
    Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
  • HY-17423
    Abacavir Inhibitor 98.17%
    Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.65%
    Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-13750
    Ebselen Inhibitor 99.89%
    Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.