1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

HSP

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-10211
    17-AAG Inhibitor
    17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
  • HY-15205
    Ganetespib Inhibitor
    Ganetespib is a unique non-geldanamycin heat shock protein 90 (HSP90) inhibitor, with antitumor activity.
  • HY-32735
    Triptolide Inhibitor
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-10215
    NVP-AUY922 Inhibitor
    NVP-AUY922 is a potent HSP90 inhibitor with IC50s of 7.8 nM/21 nM for HSP90α/β, respectively, and has weaker potency against the HSP90 family members GRP94 and TRAP-1 (IC50, 535 nM, 85 nM, respectively).
  • HY-15230
    Geldanamycin Inhibitor
    Geldanamycin is a specific inhibitor of interferon regulatory factor 3 (IRF3) (by inhibiting Hsp90 of the IRF3 phosphorylation chaperone, with a Kd of 1.2 μM.).
  • HY-15785
    TAS-116 Inhibitor
    TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
  • HY-10940
    Pifithrin-μ Inhibitor
    Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
  • HY-15096
    MKT-077 Inhibitor
    MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity.
  • HY-19356
    Rocaglamide Inhibitor
    Rocaglamide is potent and selective for heat shock reporter (IC50 of 50 nM) and for the control reporter (IC50>1000 nM).
  • HY-14463
    AT13387 Inhibitor
    AT13387 is a potent inhibitor of Hsp90, with Kd of 0.71 nM.
  • HY-10941
    VER-155008 Inhibitor
    VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
  • HY-10210
    Retaspimycin Hydrochloride Inhibitor
    Retaspimycin hydrochloride is a novel and highly soluble inhibitor of the Hsp90 ATPase activity, with EC50s of 119 nM for both Hsp90 and Grp9.
  • HY-B0779
    Teprenone Activator
    Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
  • HY-10212
    BIIB021 Inhibitor
    BIIB021 is an orally available, fully synthetic inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.
  • HY-12024
    Alvespimycin hydrochloride Inhibitor
    Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
  • HY-13469
    Debio 0932 Inhibitor
    Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
  • HY-100872
    KRIBB11 Inhibitor
    KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM.
  • HY-15190
    NVP-HSP990 Inhibitor
    NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.
  • HY-15098
    Apoptozole Inhibitor
    Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
  • HY-18680
    PU-WS13 Inhibitor
    PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.