1. NF-κB
  2. IKK


IKK (IκB kinase) is an enzyme complex that is involved in propagating the cellular response to inflammation. An IκB kinase is an enzyme that catalyzes the chemical reaction: ATP + IκB protein ADP + IκB phosphoprotein. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. IKK specifically, phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is free migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic. IKK belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins.

IKK Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-16561
    Resveratrol Inhibitor 98.90%
    Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
  • HY-13018
    MRT67307 Inhibitor 99.00%
    MRT67307 is a dual inhibitor of the IKKε and TBK-1, which mediates the phosphorylation of interferon regulatory factor 3 (IRF3), with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, and also targets ULK1 and ULK2 with high potency (IC50 values of 45 and 38 nM, respectively).
  • HY-10518
    BMS-345541 Inhibitor 99.77%
    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
  • HY-15473
    MLN120B Inhibitor 99.03%
    MLN120B is a novel IKKβ inhibitor, used for cancer treatment.
  • HY-B0713
    Amlexanox Inhibitor 99.32%
    AmLexanox is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
  • HY-U00457
    TBK1/IKKε-IN-1 Inhibitor
    TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
  • HY-105661
    IMD-0560 Inhibitor 98.68%
    IMD-0560 is a novel IκB kinase β inhibitor.
  • HY-13873
    IKK-IN-1 Inhibitor
    IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
  • HY-10074
    TPCA-1 Inhibitor 99.54%
    TPCA-1 is a potent inhibitor of IKK-2 with IC50 of 17.9 nM.
  • HY-13060
    ACHP Hydrochloride Inhibitor 98.03%
    ACHP Hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
  • HY-13687
    IKK 16 Inhibitor 99.78%
    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
  • HY-B0788
    LY2409881 Inhibitor 98.89%
    LY2409881 is a selectivr IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
  • HY-13019
    BI605906 Inhibitor 99.68%
    BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
  • HY-10172
    IMD-0354 Inhibitor 99.94%
    IMD-0354 is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC 50 of 1.2±0.3 uM.
  • HY-13802
    SC-514 Inhibitor 99.99%
    SC-514 is a selective IKK-2 inhibitor (IC50=11.2±4.7 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
  • HY-10519
    BMS-345541 free base Inhibitor 99.17%
    BMS-345541 free base is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
  • HY-18008
    PS-1145 Inhibitor 99.93%
    PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
  • HY-19362
    AZD3264 Inhibitor 99.70%
    AZD3264 is a selective IkB-kinase IKK2 inhibitor.
  • HY-12453
    TBK1/IKKε-IN-2 Inhibitor 98.50%
    TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
  • HY-50948
    Bay 65-1942 hydrochloride Inhibitor
    Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.