1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2, 3-dioxygenase (IDO) is an intracellular enzyme that catalyzes the transformation of L-tryptophan to N-formylkynurenine, which is the first and rate-controlling step in the kynurenine pathway.

IDO is a rate-limiting enzyme that catalyzes the degradation of tryptophan into kynurenine and is recognized to exert a tolerizing effect on T cells that require tryptophan to proliferate5. IDO also plays an important role in the activation and regulation of functionally quiescent regulatory T cells.

IDO is a heme-containing enzyme that catalyzes the oxidative cleavage of 2,3 double bond of indole ring. IDO has the ability to inhibit T-cell activation by tryptophan starvation, whereas T-cell survival and proliferation are regulated by O2 free radicals and kynurenine derivatives. IDO plays a crucial role in autoimmunity,infections and malignancies.

Indoleamine-2,3-dioxygenase (IDO) one of the most important immunoregulator enzyme responsible for metabolism of tryptophan as part of Kynurenin pathway. Tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme IDO expressed in tumor cells or antigen presenting cells.

Indoleamine 2,3-Dioxygenase (IDO) Related Products (19):

Cat. No. Product Name Effect Purity
  • HY-15689
    INCB 024360 Inhibitor 99.65%
    INCB 024360 is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM.
  • HY-13983
    IDO-IN-7 Inhibitor 99.92%
    IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor (IC50=38 nM)
  • HY-16724
    Indoximod Inhibitor 98.98%
    Indoximod ( D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.
  • HY-15683
    IDO5L Inhibitor 99.29%
    IDO-IN-2 is a potent IDO1 inhibitor with IC50 of 19 nM in Hela cell assay.
  • HY-18770B
    Navoximod Inhibitor 99.99%
    Navoximod (NLG919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
  • HY-115122
    IDO-IN-12 Inhibitor
    IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.
  • HY-110387
    IDO-IN-9 Inhibitor
    IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1.
  • HY-111234
    IDO-IN-11 Inhibitor
    IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1.
  • HY-13555
    β-Lapachone Inhibitor 99.72%
    β-Lapachone(ARQ-501; beta-lapachone) is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties; potent inhibitor of IDO1(IC50=0.44 uM).
  • HY-101111
    PF-06840003 Inhibitor 99.80%
    PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor.
  • HY-100687
    8-Nitrotryptanthrin Inhibitor 99.21%
    8-Nitrotryptanthrin is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
  • HY-18769
    IDO-IN-4 Inhibitor 98.90%
    IDO-IN-4 is a potent IDO1 inhibitor with IC50 of 8 nM in human IDO1/HEK293 cells.
  • HY-18770
    IDO-IN-5 Inhibitor 99.90%
    IDO-IN-5 is a potent human IDO inhibitor with IC50 of 1-10 μM.
  • HY-101560
    BMS-986205 Inhibitor 98.70%
    BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
  • HY-18770C
    IDO-IN-8 Inhibitor 99.99%
    IDO-IN-8 is a potent human IDO inhibitor with IC50 of 1-10 μM.
  • HY-16987
    IDO-IN-3 Inhibitor
    IDO-IN-3 is a potent IDO inhibitor.
  • HY-18770A
    IDO-IN-6 Inhibitor 99.90%
    IDO-IN-6 is a potent human IDO inhibitor with IC50 of <1 μM.
  • HY-79531
    IDO-IN-1 Inhibitor
    IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM).
  • HY-100771
    IDO-IN-2 Inhibitor 98.54%
    IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.