1. Protein Tyrosine Kinase/RTK
  2. Itk


Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-11092
    BMS-509744 Inhibitor 98.02%
    BMS-509744是有效,选择性的 Itk 激酶抑制剂,IC50 值为19 nM。
  • HY-12680
    PRN694 Inhibitor 99.44%
    PRN694 is a highly selective and potent covalent inhibitor of T cell kinase (ITK) and resting lymphocyte kinase (RLK) with IC50s of 0.3 and 1.4 nM, respectively.
  • HY-109078
    Vecabrutinib Inhibitor 99.96%
    Vecabrutinib is a potent, noncovalent BTK and ITK inhibitor, with Kd of 0.3 nM and 2.2 nM, respectively; Vecabrutinib shows an IC50 of 24 nM for ITK.
  • HY-11066
    ITK inhibitor Inhibitor
    ITK inhibitor is a potent ITK inhibitor.
  • HY-16984
    GNE-4997 Inhibitor
    GNE-4997 is a potent and selective ITK/TSK inhibitor.