1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin

Kinesin

Kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo. Most kinesins walk towards the plus end of a microtubule, entails transporting cargo from the centre of the cell towards the periphery. Kinesins were discovered as microtubule (MT)-based anterograde intracellular transport motors. The founding member of this superfamily, the genomes of mammals encode more than 40 kinesin proteins, organized into at least 14 families named kinesin-1 through kinesin-14.

Kinesin Related Products (16):

Cat. No. Product Name Effect Purity
  • HY-15187
    ARRY-520 Inhibitor
    ARRY-520 is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-15948
    Kif15-IN-1 Inhibitor
    Kif15-IN-1 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
  • HY-50759
    Ispinesib Inhibitor
    Ispinesib is a specific inhibitor of KSP, with a Ki app of 1.7 nM.
  • HY-10299
    GSK-923295 Inhibitor
    GSK-923295 is a special, allosteric inhibitor of CENP-E kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
  • HY-101071A
    Monastrol Inhibitor
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
  • HY-14846
    Litronesib Inhibitor
    Litronesib is a selective Eg5 inhibitor, with antitumor activity.
  • HY-15949
    Kif15-IN-2 Inhibitor
    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
  • HY-15857
    CW-069 Inhibitor
    CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM.
  • HY-19530
    PF-2771 Inhibitor
    PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent.
  • HY-19966
    K858 Inhibitor
    K858 is an ATP-uncompetitive inhibitor of Eg5 with an IC50 of 1.3 μM.
  • HY-15187A
    ARRY-520 R enantiomer Inhibitor
    ARRY-520 R enantiomer is the R-enantiomer of ARRY-520. ARRY-520 is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
  • HY-12069
    SB-743921 Inhibitor
    SB-743921 is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
  • HY-15000
    EMD534085 Inhibitor
    EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
  • HY-19944
    Dimethylenastron Inhibitor
    Dimethylenastron is a potent Eg5 inhibitor, with an IC50 of 200 nM.
  • HY-14846A
    Litronesib Racemate
    Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of Eg5.
  • HY-101298
    Paprotrain Inhibitor
    Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.