1. Metabolic Enzyme/Protease
  2. LXR


LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ABCA1 and ABCG1 transporters, in macrophage and intestine.

LXRα/β are ligand-activated transcription factors of the nuclear hormone receptor superfamily that stimulate transcription of several genes, including ABCA1 and apoE. LXRα and LXRβ respond to the same oxysterol ligands and activate transcription as obligate heterodimeric complexes with retinoid X receptors.

Synthetic LXR agonists activate both LXRα and LXRβ, cross the blood-brain barrier, and efficiently induce expression of LXR target genes including ABCA1 and apoE.

LXR Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-10627A
    GW3965 hydrochloride Agonist
    GW3965 (hydrochloride) is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.
  • HY-10626
    T0901317 Agonist 99.64%
    T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 (mu)M, respectively, inhibits nuclear factor/(kappa)B (NF/(kappa)B).
  • HY-10629
    LXR-623 Agonist 98.93%
    LXR-623 is a highly brain-penetrant LXRα-partial/LXRβ-full agonist, with IC50 of 179 and 24 nM for LXR-β and the LXR-α subtype, respectively.
  • HY-14823
    Sobetirome Agonist >98.0%
    Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist, Sobetirome is designed to bind selectively to TRβ-1 with EC50 of 0.16 μM.
  • HY-16972
    SR9243 Antagonist 98.99%
    SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.
  • HY-108688
    GSK2033 Antagonist
    GSK2033 is a LXR antagonist with pIC50s of 7 nM and 7.4 nM for LXRα or LXRβ, respectively.
  • HY-101442
    SR9238 Antagonist
    SR9238 is a synthetic LXR antagonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ, respectively.
  • HY-101973
    BMS-852927 Agonist 99.11%
    BMS-852927 is an LXRβ-selective agonist.
  • HY-18282
    AZ876 Agonist 99.76%
    AZ876 is a novel high-affinity LXR agonist.
  • HY-19919
    BMS-779788 Agonist >98.0%
    BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.
  • HY-N2371
    27-Hydroxycholesterol Agonist 99.00%
    27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
  • HY-N2370
    24-Hydroxycholesterol Activator >98.0%
    24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
  • HY-10627
    GW3965 Agonist
    GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.