1. Metabolic Enzyme/Protease
  2. Lactate Dehydrogenase

Lactate Dehydrogenase

Lactate Dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate.

Mammalian lactate dehydrogenase (LDH) comprises three major families of conserved enzymes that catalyse the reversible interconversion of pyruvate and lactate, a key metabolic step in glycolysis and other metabolic pathways. At least five LDH tetrameric isozymes are reported in somatic mammalian tissues, comprising LDHA and LDHB subunits, whereas LDHC4 is found only in mature testis and spermatozoa, where it is required for male fertility. Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. At high concentrations of lactate, the enzyme exhibits feedback inhibition, and the rate of conversion of pyruvate to lactate is decreased.

Lactate Dehydrogenase Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-100742
    GNE-140 racemate Inhibitor 99.53%
    GNE-140 racemate is a LDHA inhibitor.
  • HY-100681
    GSK2837808A Inhibitor >98.0%
    GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.
  • HY-100742B
    (S)-GNE-140 Inhibitor
    (S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).
  • HY-100742A
    (R)-GNE-140 Inhibitor 98.50%
    (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.