1. GPCR/G Protein
  2. Leukotriene Receptor

Leukotriene Receptor

Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.

Leukotriene Receptor Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-19989A
    MK-571 sodium salt Antagonist
    MK571 sodium salt is a specific CysLT1 (Cysteinyl-Leukotriene Type 1 Receptor) antagonist.
  • HY-13315
    Montelukast sodium Antagonist
    Montelukast sodium is a potent, selective CysLT1 receptor antagonist.
  • HY-17492
    Zafirlukast Antagonist
    Zafirlukast is a leukotriene receptor antagonist (LTRA).
  • HY-13448
    Nedocromil Inhibitor
    Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma.
  • HY-B0290A
    Pranlukast hemihydrate Antagonist
    Pranlukast is an orally administered, selective, cysteinyl leukotriene receptor-1 antagonist, pranlukast, a widely used leukotriene C4, D4, and E4 antagonist, together with antibiotics could inhibit the progression to SOM.
  • HY-100316
    CP-96486 Antagonist
    CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
  • HY-100173
    DW-1350 Antagonist
    DW-1350 is a LTB4 receptor antagonist.
  • HY-B0290
    Pranlukast Antagonist
    Pranlukast is a selective cysteinyl leukotriene receptor antagonist.
  • HY-101946
    AS-35 Antagonist
    AS-35 is an orally effective, potent and selective antagonist of leukotrienes, with antiallergic activities.
  • HY-101438A
    Darbufelone mesylate Inhibitor
    Darbufelone mesylate is a dual inhibitor of cellular prostaglandin and leukotriene production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).
  • HY-U00027
    Quinotolast sodium Inhibitor
    Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits histamine and LTC4 release in a concentration-dependent manner.
  • HY-101676
    RG-12525 Antagonist
    RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4; Also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.
  • HY-101686
    LM-1484 Antagonist
    LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for 3H-LTC4 sites.
  • HY-14938
    KCA 757 Antagonist
    KCA 757 is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma.
  • HY-U00072
    RS-601 Antagonist
    RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
  • HY-U00359
    LTD4 antagonist 1 Antagonist
    LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
  • HY-U00263
    LY210073 Antagonist
    LY210073 is a Leukotriene B4 (LTB4) receptor antagonist with an IC50 of 6.2 nM.
  • HY-U00364
    CI-949 Inhibitor
    CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
  • HY-U00253
    KP496 Antagonist
    KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.
  • HY-U00355
    YM158 free base Antagonist
    YM158 free base is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.