1. Metabolic Enzyme/Protease
  2. MMP

MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-N0565B
    Doxycycline hyclate Inhibitor 98.42%
    Doxycycline (hyclate) is a tetracycline antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.
  • HY-15768
    GM6001 Inhibitor 98.23%
    GM6001 is a broad spectrum matrix metalloprotease (MMP) inhibitor, with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM for MMP-1/2/3/7/8/9/12/14/26, respectively.
  • HY-12270
    T-5224 Inhibitor 99.03%
    T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1 for rheumatoid arthritis therapy, and inhibits MMP activity with IC50s of 10 nM for both MMP-3 and MMP-13.
  • HY-12354
    SB-3CT Inhibitor 99.32%
    SB-3CT is a potent and selective inhibitor of matrix metalloproteinase (MMP-2) and MMP-9.
  • HY-13564
    Batimastat Inhibitor
    Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
  • HY-19677
    Cipemastat Inhibitor
    Cipemastat is a potent, competitive inhibitor of human collagenases 1, 2 and 3 with Kis of 3.0, 4.4 and 3.4 nM, respectively.
  • HY-19485
    XL-784 Inhibitor
    XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively.
  • HY-N0262
    Cordycepin Inhibitor >99.0%
    Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.
  • HY-12169
    Marimastat Inhibitor
    Marimastat is a broad spectrum inhibitor of MMPs with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively.
  • HY-N0431
    Astragaloside IV Inhibitor 99.15%
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
  • HY-100211
    TAPI-2 Inhibitor
    TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP.
  • HY-16657
    TAPI-1 Inhibitor 99.89%
    TAPI-1 is a specific TACE(TNF-α-converting enzyme) inhibitor.
  • HY-19956
    GI254023X Inhibitor 99.67%
    GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively.
  • HY-10398
    CTS-1027 Inhibitor 98.72%
    CTS-1027 is a potent small molecule inhibitor of MMPs, with IC50s of 0.3 nM, 0.5 nM for MMP2, MMP13, respectively, and has > 1,000 fold selectivity over MMP1.
  • HY-B0099
    Edaravone Inhibitor 99.90%
    Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
  • HY-103482
    JNJ0966 Inhibitor 98.01%
    JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.
  • HY-100359
    CL-82198 Inhibitor 98.03%
    CL-82198 is a selective inhibitor of MMP-13.
  • HY-N2117
    Isoginkgetin Inhibitor 99.06%
    Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.
  • HY-15827
    NSC 405020 Inhibitor 99.01%
    NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.
  • HY-N0035
    Arctigenin Inhibitor 98.46%
    Arctigenin is a lignan found in certain plants of the Asteraceae; it has shown antiviral and anticancer effects in glass; it is the aglycone of arctiin.