1. Neuronal Signaling
  2. Monoamine Oxidase

Monoamine Oxidase

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Related Products (37):

Cat. No. Product Name Effect Purity
  • HY-B1496
    Tranylcypromine hemisulfate Inhibitor
    Tranylcypromine hemisulfate, an LSD1 inhibitor, and also an irreversible, nonselective MAO inhibitor, is used in the treatment of depression.
  • HY-14197A
    Clorgiline hydrochloride Inhibitor
    Clorgiline is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.
  • HY-14199
    R-(-)-Deprenyl hydrochloride Inhibitor
    R-(-)-Deprenyl Hydrochloride is a selective inhibitor of monoamine oxidase B (MAO-B).
  • HY-A0091
    Pargyline hydrochloride Inhibitor
    Pargyline hydrochloride is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.
  • HY-B1018A
    Phenelzine sulfate Inhibitor
    Phenelzine sulfate is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.
  • HY-107828
    Harmaline Inhibitor
    Harmaline is a potent and reversible monoamine oxidase inhibitor in vivo. Harmaline is a central nervous system stimulant and can be used to induce tremor in rodents.
  • HY-22385
    Salsolidine Inhibitor
    Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
  • HY-100178
    CX-157 Inhibitor
    CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.
  • HY-N0529
    Rosmarinic acid Inhibitor
    Rosmarinic acid (RA) is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.
  • HY-14605
    Rasagiline mesylate Inhibitor
    Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.
  • HY-16677A
    Mofegiline hydrochloride Inhibitor
    Mofegiline Hcl (MDL72974A) is a potent and selective enzyme-activated irreversible inhibitor of MAO-B; shows marked selectivity for the B form (IC50 = 680 and 3.6 nM for MAO-A and MAO-B, respectively.
  • HY-100546A
    GSK-LSD1 Dihydrochloride Inhibitor
    GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
  • HY-70057
    Safinamide Inhibitor
    Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.
  • HY-B0886
    Iproniazid phosphate Inhibitor
    Iproniazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class.
  • HY-N0159
    Paeonol Inhibitor
    Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
  • HY-100027A
    Ro 41-1049 hydrochloride Inhibitor
    Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor.
  • HY-B0884
    Minaprine Inhibitor
    Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.
  • HY-14200
    TVP1022 Inhibitor
    TVP1022 is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.
  • HY-B1083
    Modaline sulfate Inhibitor
    Modaline Sulfate is a MAO inhibitor, used in the treatment of depression.
  • HY-B1199
    Nialamide Inhibitor
    Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.