2. GPCR/G Protein
  3. Motilin Receptor

Motilin Receptor

Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.

Motilin Receptor Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-144401
    DS-3801b Agonist 98.31%
    DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation[1].
  • HY-10922A
    Camicinal hydrochloride Agonist 98.96%
    Camicinal hydrochloride (GSK962040 hydrochloride) is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.
  • HY-P1037
    Motilin (26-47), human, porcine Agonist 98.11%
    Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
  • HY-107642
    MA-2029 Antagonist 99.79%
    MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility[1].
  • HY-10922
    Camicinal Agonist
    Camicinal (GSK962040) is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.
  • HY-P1233
    ANQ-11125 Antagonist
    ANQ-11125 is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit[1][2].
  • HY-P1233A
    ANQ-11125 TFA Antagonist
    ANQ-11125 TFA is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit[1][2].
  • HY-105263
    EM574 Agonist
    EM574 is a potent motilin receptor agonist in the human gastric antrum and rabbit gastrointestinal tract in vitro. EM574 is an erythromycin derivative[1].
  • HY-P3680
    [Nle13]-Motilin Agonist
    [Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist[1][2].