1. GPCR/G Protein
  2. Motilin Receptor

Motilin Receptor

Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.

Motilin Receptor Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-10922
    GSK962040 Agonist
    GSK962040(Camicinal) is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.
  • HY-10922A
    GSK962040 hydrochloride Agonist
    GSK962040 is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.
  • HY-P1037
    Motilin (26-47), human, porcine Agonist
    Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. Sequence: Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln.