1. Cell Cycle/DNA Damage
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  2. Mps1

Mps1

Monopolar spindle 1 (Mps1/TTK) is a serine/threonine kinase conserved from yeast to human. It has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

MPS1, a dual specificity protein kinase, is also one of the main components of the SAC and ensures cells do not progress from metaphase to anaphase until the kinetochores are properly attached to the microtubules and under the appropriate tension at the metaphase plate. Cancer cells heavily rely on MPS1 to cope with aneuploidy resulting from aberrant numbers of chromosomes. The kinase has been found to be upregulated in a large number of tumor types. Mps1 is an attractive oncology target due to its high expression level in cancer cells as well as the correlation of its expression levels with histological grades of cancers.

Mps1 Related Products (21):

Cat. No. Product Name Effect Purity
  • HY-101340A
    Luvixasertib hydrochloride Inhibitor 99.48%
    CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity[1].
  • HY-12859
    BAY1217389 Inhibitor 99.94%
    BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
  • HY-12660
    MPI-0479605 Inhibitor 99.51%
    MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
  • HY-12382
    NMS-P715 Inhibitor 98.41%
    NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
  • HY-14710
    AZ3146 Inhibitor 99.92%
    AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.
  • HY-160419
    Mps1-IN-8 Inhibitor
    Mps1-IN-8 is a Mps1 inhibitor. Mps1-IN-8 can be used in the study of various tumors[1].
  • HY-12603
    CCT251455 Inhibitor 98.26%
    CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.
  • HY-151980
    Mps1-IN-5 Inhibitor
    Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1].
  • HY-13994
    Mps1-IN-2 Inhibitor 98.04%
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
  • HY-110347
    Mps1-IN-1 dihydrochloride Inhibitor
    Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC50 of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells[1].
  • HY-144308
    RMS-07 Inhibitor
    RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region[1].
  • HY-112162
    BOS-172722 Inhibitor 98.65%
    BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].
  • HY-149959
    Mps1-IN-6 Inhibitor
    Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM. Mps1-IN-6 shows antiproliferative activity. Mps1-IN-6 shows antitumor activity[1].
  • HY-12858
    Empesertib Inhibitor
    Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
  • HY-110115
    TC-Mps1-12 Inhibitor
    TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM[1].
  • HY-110242
    Mps-BAY2a Inhibitor 98.74%
    Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].
  • HY-12658
    Mps1-IN-4 Inhibitor
    Mps1-IN-4 is a selective Monopolar spindle 1 (Mps1) inhibitor with antiproliferative activity for cancer research[1].
  • HY-12401
    Mps1-IN-3 Inhibitor
    Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.
  • HY-12862
    Mps1-IN-7 Inhibitor 98.55%
    Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50= 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively[1].
  • HY-13298
    Mps1-IN-1 Inhibitor 99.37%
    Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM[1].