1. Metabolic Enzyme/Protease
  2. Neprilysin

Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Neprilysin Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-18204A
    LCZ696 Inhibitor 99.96%
    LCZ696 is a dual angiotensin II receptor and neprilysin inhibitor.
  • HY-15407
    AHU-377 Inhibitor 99.14%
    AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
  • HY-15407A
    AHU-377 hemicalcium salt Inhibitor 99.61%
    AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon disodium is a metalloprotease inhibitor. Phosphoramidon inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
  • HY-17399
    Racecadotril Inhibitor >98.0%
    Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation.
  • HY-17620
    Sacubitrilat Inhibitor 99.88%
    Sacubitrilat is an active neprilysin (NEP) inhibitor.
  • HY-U00171
    SQ28603 Inhibitor
    SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).