1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (42):

Cat. No. Product Name Effect Purity
  • HY-90006
    5-Fluorouracil Inhibitor
    5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
  • HY-10586
    5-Azacytidine Inhibitor
    5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
  • HY-17026
    Gemcitabine Inhibitor
    Gemcitabine is a DNA synthesis inhibitor with IC50 of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.
  • HY-13605
    Cytarabine Inhibitor
    Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
  • HY-B0003
    Gemcitabine Hydrochloride Inhibitor
    Gemcitabine hydrochloride is a DNA synthesis inhibitor with IC50 of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.
  • HY-B1468
    8-Azaguanine Chemical
    8-Azaguanine is a purine analogue which shows antineoplastic activity.
  • HY-16445
    Sapacitabine Chemical
    Sapacitabine is an orally available nucleoside analog prodrug that is structurally related to cytarabine.
  • HY-15910
    5-BrdU Inhibitor
    5-BrdU is a nucleoside analog, and competes with thymidine for incorporation into DNA, and is used in the detection of proliferating cells.
  • HY-B0016
    Capecitabine Inhibitor
    Capecitabine is an oral prodrug that is converted to its only active metabolite, fluorouracil (FU), by thymidine phosphorylase.
  • HY-16209
    Forodesine hydrochloride Inhibitor
    Forodesine Hcl (BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.
  • HY-10821
    Raltitrexed Inhibitor
    Raltitrexed is an inhibitor of thymidylate synthase and an antimetabolite drug used for cancer treatment.
  • HY-A0061
    Trifluorothymidine Inhibitor
    Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
  • HY-B0028
    Fludarabine phosphate Inhibitor
    Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
  • HY-B0097
    Floxuridine Inhibitor
    Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.
  • HY-B0078
    Dacarbazine Inhibitor
    Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent.
  • HY-13677
    6-Mercaptopurine Antagonist
    6-Mercaptopurine hydrate is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.
  • HY-B0277
    Vidarabine Inhibitor
    Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses.
  • HY-B0228
    Adenosine Chemical
    Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
  • HY-13986
    Merimepodib Inhibitor
    Merimepodib is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase).
  • HY-A0063
    Tipiracil hydrochloride Inhibitor
    Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.