1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Opioid Receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Related Products (61):

Cat. No. Product Name Effect Purity
  • HY-12745A
    Nalfurafine hydrochloride Agonist
    Nalfurafine hydrochloride is a κ-opioid agonist and an anti-itch drug approved in Japan.
  • HY-75766
    Methylnaltrexone Bromide Antagonist
    Methylnaltrexone (Bromide) is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
  • HY-76710
    Naltrexone Hydrochloride Antagonist
    Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
  • HY-101386
    PZM21 Agonist
    PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM.
  • HY-13044
    ADL-5859 Agonist
    ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
  • HY-112263
    ORL1 antagonist 1 Antagonist
    ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.
  • HY-P1599
    Valorphin
    Valorphin is an endogenous hemoglobin β-chain (33-39) fragment with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM; Valorphin also shows anti-tumor activity.
  • HY-P1596
    Gluten Exorphin C Inhibitor
    Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.
  • HY-B0418A
    Loperamide hydrochloride Agonist
    Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals.
  • HY-G0021
    N-Desmethylclozapine Agonist
    N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.
  • HY-10487
    JDTic dihydrochloride Antagonist
    JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
  • HY-P0073
    Tyr-Gly-Gly-Phe-Met-OH Activator
    Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.
  • HY-13274
    JTC-801 Antagonist
    JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.
  • HY-101718
    LY-2456302 Antagonist
    LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
  • HY-N0164
    Matrine Agonist
    Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus.
  • HY-15536
    Cebranopadol Agonist
    Cebranopadol is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.
  • HY-101177
    Naltrindole hydrochloride Antagonist
    Naltrindole hydrochloride is a highly potent and selective non-peptide δ opioid receptor antagonist with a Ki of 0.02 nM.
  • HY-15122A
    Sinomenine hydrochloride Activator
    Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-opioid receptor.
  • HY-105343
    DADLE Agonist
    DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.
  • HY-111454
    SR17018 Agonist
    SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.