1. GPCR/G Protein
  2. Oxytocin Receptor

Oxytocin Receptor

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Oxytocin Receptor Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-17571A
    Oxytocin acetate Agonist 99.79%
    Oxytocin ((alpha)-Hypophamine) acetate is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.
  • HY-17572
    Atosiban Antagonist 99.09%
    Atosiban(RW22164; Tractocile) is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).
  • HY-17573
    Carbetocin Agonist >98.0%
    Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors.
  • HY-15023
    PF-3274167 Antagonist 99.40%
    PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.
  • HY-15015
    OT-R antagonist 1 Antagonist >98.0%
    OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist.
  • HY-14778
    Retosiban Antagonist
    Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.
  • HY-103651
    OT antagonist 1 demethyl derivative Antagonist
    OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1. OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
  • HY-103650
    OT antagonist 1 Antagonist
    OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
  • HY-17571
    Oxytocin Agonist 98.68%
    Oxytocin ((alpha)-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.
  • HY-108677
    L-368,899 hydrochloride Antagonist
    L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.
  • HY-15015A
    OT-R antagonist 2 Antagonist >98.0%
    OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 2 inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 (mu)M).
  • HY-103649
    OT antagonist 3 Antagonist
    OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.
  • HY-105018
    GSK 557296 Antagonist
    GSK 557296 is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor.