1. GPCR/G Protein
  2. P2Y Receptor

P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y8, P2Y9, P2Y10, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y2 is a potential drug target for treating cystic fibrosis. P2Y11 is a regulator of immune response, and a common polymorphism carried by almost 20% of North European caucasians give increased risk of myocardial infarction, making P2Y11 an interesting drug target candidate for treatment of myocardial infarction. P2Y12 is the target of the anti-platelet drug clopidogrel and other thienopyridines.

P2Y Receptor Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-B0879A
    Suramin sodium salt Inhibitor >98.0%
    Suramin sodium salt is a polysulfonated naphthylurea with various biological activities. Suramin sodium salt is a DNA topoisomerase II inhibitor with an IC50 of 5 μM.
  • HY-10064
    Ticagrelor Antagonist 99.99%
    Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
  • HY-17459
    Clopidogrel hydrogen sulfate Inhibitor
    S-((addition))-Clopidogrel Hydrogen Sulfate is the S enantiomer of clopidogrel and a P2Y12 receptor inhibitor.
  • HY-13104
    MRS 2578 Antagonist
    MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
  • HY-15284
    Prasugrel Inhibitor >98.0%
    Prasugrel is a platelet inhibitor with IC50 value of 1.8 (mu)M.
  • HY-13831
    BPTU Antagonist 98.03%
    BPTU is a novel P2Y1 allosteric antagonist.
  • HY-U00196
    Denufosol tetrasodium Agonist
    Denufosol tetrasodium is a long- acting P2Y2 receptor agonist, which exhibits an EC50 of ~10 μM for P2Y2 receptor activation.
  • HY-B0606
    Diquafosol tetrasodium Agonist 99.20%
    Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
  • HY-15876
    Clopidogrel thiolactone Inhibitor >98.0%
    Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.
  • HY-15799
    AZD1283 Antagonist 98.85%
    AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11 nM.
  • HY-18775
    N6-(4-Hydroxybenzyl)adenosine Inhibitor >98.0%
    N6-(4-Hydroxybenzyl)adenosine is a inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 (mu)M).
  • HY-B0879
    Suramin Inhibitor
    Suramin is a polysulfonated naphthylurea with various biological activities. Suramin is a DNA topoisomerase II inhibitor with an IC50 of 5 μM.
  • HY-15283
    Clopidogrel Inhibitor
    Clopidogrel is a well-known P2Y12 receptor blocker.
  • HY-15284B
    Prasugrel Maleic acid Inhibitor
    Prasugrel Maleic acid is a platelet inhibitor with IC50 value of 1.8 (mu)M.
  • HY-15284A
    Prasugrel hydrochloride Inhibitor
    Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 (mu)M.