1. PI3K/Akt/mTOR
  2. PDK-1

PDK-1

PDK-1 (phosphoinositide dependent protein kinase-1) is a protein which in humans is encoded by the PDK1 gene. It is implicated in the development and progression of melanomas. PDK-1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDK-1 is in the signalling pathways activated by several growth factors and hormones including insulin signaling. More recent data indicate that alteration of PDK-1 is a critical component of oncogenic PI3K signalling in breast cancer, suggesting that inhibition of PDK-1 can inhibit breast cancer progression. PDK-1 has an essential role in regulating cell migration especially in the context of PDK-1 deficiency. PDK-1 is a valid therapeutic target and suggests that PDK-1 inhibitors may be useful to prevent cancer progression and abnormal tissue dissemination.

PDK-1 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-10514
    BX795 Inhibitor 99.33%
    BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM, respectively, and has > 50 fold selectivity over PKA, PKC, c-Kit, GSK3β etc.
  • HY-14981
    GSK2334470 Inhibitor 99.78%
    GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
  • HY-14440
    MP7 Inhibitor 99.36%
    MP7 is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.
  • HY-11005
    BX-912 Inhibitor 98.94%
    BX-912 is a potent PDK1 inhibitors with an IC50 of 12 nM.
  • HY-13842
    BX517 Inhibitor >98.0%
    BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.