1. Epigenetics
    TGF-beta/Smad
  2. PKC

PKC

PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-18739
    Phorbol 12-myristate 13-acetate Activator
    Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
  • HY-15141
    Staurosporine Inhibitor
    Staurosporine is a very potent universal inhibitor of protein kinases but showing little selectivity, with IC50 of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase, respectively.
  • HY-10230
    PKC412 Inhibitor
    PKC412 is an inhibitor of protein kinase C (PKC) and can inhibit other kinases including PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR.
  • HY-13689
    Go 6983 Inhibitor
    Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
  • HY-13867
    Bisindolylmaleimide I Inhibitor
    Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.
  • HY-106262
    KAI-9803 Inhibitor
    KAI-9803 is a potent and selective δ-protein kinase C (δPKC) inhibitor.
  • HY-12048
    Chelerythrine Chloride Inhibitor
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-10343
    Sotrastaurin Inhibitor
    Sotrastaurin is a potent pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.
  • HY-13866
    Ro 31-8220 mesylate Inhibitor
    Ro 31-8220 mesylate (Bisindolylmaleimide IX) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
  • HY-10342
    Enzastaurin Inhibitor
    Enzastaurin is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε.
  • HY-13777A
    Zoledronic acid monohydrate Activator
    Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines.
  • HY-10195B
    Ruboxistaurin hydrochloride Inhibitor
    Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily.
  • HY-B0719
    Ingenol Mebutate Activator
    Ingenol Mebutate (PEP 005) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
  • HY-13502A
    Mitoxantrone dihydrochloride Inhibitor
    Mitoxantrone dihydrochloride is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
  • HY-13502
    Mitoxantrone Inhibitor
    Mitoxantrone is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
  • HY-13772
    Valrubicin Activator
    Valrubicin (AD-32) is a chemotherapy drug used to treat bladder cancer.
  • HY-11009
    CGP60474 Inhibitor
    CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.
  • HY-N0021
    Verbascoside Inhibitor
    Verbascoside(Acteoside; TJC160), is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity; protein kinase C inhibitor (IC50 =25 uM).
  • HY-12307
    (-)-Indolactam V Activator
    (-)-Indolactam V (ILV) is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
  • HY-18931A
    NSC305787 hydrochloride Inhibitor
    NSC305787 hydrochloride is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.