1. Cell Cycle/DNA Damage
  2. PPAR

PPAR

PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.

PPAR Related Products (66):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Agonist
    Rosiglitazone is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
  • HY-16578
    GW9662 Antagonist
    GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with ~10 and ~1000-fold functional selectivity in cells against PPARα and PPARδ, respectively.
  • HY-14649
    Retinoic acid Agonist
    Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid also bind to PPARβ/δ, with Kd of 17 nM.
  • HY-16737
    Elafibranor Agonist
    Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
  • HY-10838
    GW 501516 Agonist
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
  • HY-107901
    Pparδ agonist 1 Inhibitor
    Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
  • HY-19522
    Seladelpar Agonist
    Seladelpar is an orally active, potent (50% effect concentration EC50 2 nM), and specific PPAR-δ agonist.
  • HY-N1426
    Raspberry ketone Agonist
    Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
  • HY-50935
    Troglitazone Agonist
    Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
  • HY-14601
    Pioglitazone hydrochloride Agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-17356
    Fenofibrate Agonist
    Fenofibrate is a relatively potent inhibitor of CYP2C19 (IC50=0.2 μM) and CYP2B6 (IC50=0.7 μM). Fenofibrate is also a well-known PPARα agonist (EC50=30 μM).
  • HY-13202
    T0070907 Antagonist
    T0070907 is a potent PPARγ antagonist and a potential RAD51 inhibitor, with the Ki value of 1 nM towards PPARγ.
  • HY-17618
    Pemafibrate Agonist
    Pemafibrate is a potent PPARα agonist, with EC50s of 1 nM, 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, respectively, and possesses lipid-lowering effect.
  • HY-15725
    CDDO-Im Activator
    CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ, also has anti-cancer and anti-inflammatory activities.
  • HY-13928
    GW0742 Agonist
    GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
  • HY-16995
    Wy-14643 Agonist
    Wy-14643 is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
  • HY-15721
    FH535 Inhibitor
    FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
  • HY-N0019
    Daidzein Activator
    Daidzein is a soy isoflavone, which acts as a PPAR activator.
  • HY-12377
    GSK0660 Antagonist
    GSK0660 is a potent antagonist of PPARβ and PPARδ, with IC50s of both 155 nM, and is nearly inactive on PPARα and PPARγ with IC50s of both >10 μM.
  • HY-N0014
    Icariin Activator
    Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.