2. Cell Cycle/DNA Damage
  3. PPAR

PPAR

PPAR

Related Products

PDF 0.63 MB

PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.

PPAR Related Products (74):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Agonist 99.21%
    Rosiglitazone (BRL49653) is a potent thiazolidinedione insulin sensitizer. Rosiglitazone is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
  • HY-16578
    GW9662 Antagonist 99.53%
    GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
  • HY-14649
    Retinoic acid Agonist 98.36%
    Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
  • HY-16737
    Elafibranor Agonist 99.31%
    Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
  • HY-10838
    GW 501516 Agonist 99.26%
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
  • HY-114263
    NXT629 Antagonist
    NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively[1]. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models[2].
  • HY-114739
    MA-0204 Modulator
    MA-0204 is a potent, highly selective PPARδ modulator with EC50s of 0.4, 7.9 and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD) [1].
  • HY-106266
    Chiglitazar Agonist
    Chiglitazar is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.
  • HY-50935
    Troglitazone Agonist
    Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
  • HY-14601
    Pioglitazone hydrochloride Agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
  • HY-13202
    T0070907 Antagonist 99.34%
    T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
  • HY-17356
    Fenofibrate Agonist 99.92%
    Fenofibrate is a PPARα agonist with an EC50 of 30 μM.
  • HY-17618
    Pemafibrate Agonist 99.78%
    Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
  • HY-15725
    CDDO-Im Activator 98.20%
    CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ.
  • HY-16995
    Wy-14643 Agonist 99.69%
    Wy-14643 is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.
  • HY-13928
    GW0742 Agonist 99.63%
    GW0742 is a high affinity PPAR β/δ agonist with an IC50 of 1 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
  • HY-15655
    GW1929 Agonist 99.68%
    GW1929 is a potent PPAR-γ agonist, with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
  • HY-N0182
    Fisetin Inhibitor >98.0%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-N0014
    Icariin Activator 98.75%
    Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.