1. PROTAC
  2. PROTAC Linker

PROTAC Linker

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linker Related Products (2041):

Cat. No. Product Name Effect Purity
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 99.78%
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W008005
    Amino-PEG4-alcohol
    Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
  • HY-W008474
    Boc-NH-PEG2-C2-NH2 99.01%
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-W016735
    Azido-PEG3-alcohol
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-42776
    NH2-PEG3-C2-NH-Boc >98.0%
    NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-140087
    N-(Amino-PEG2)-N-bis(PEG3-azide)
    N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 98.31%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation[1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2].
  • HY-W015088
    Amino-PEG3-C2-Amine 98.80%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
  • HY-W008574
    TGN-020 99.44%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4].
  • HY-22335
    Amino-PEG4-C2-amine
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH >98.0%
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs)[1].
  • HY-108370
    N33-TEG-COOH >98.0%
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-23408
    Tos-PEG3
    Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].
  • HY-23417
    PEG5-Tos 99.05%
    PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-40178
    NH2-C4-NH-Boc
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
  • HY-W017772
    Boc-NH-PEG3 >98.0%
    Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-42637
    N3-PEG3-CH2COOH
    N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-W004945
    3,6-Dioxaoctanedioic acid
    36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W007545
    NH2-PEG3
    NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1)[1].