2. PROTAC
  3. PROTAC Linkers

PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Related Products (2819):

Cat. No. Product Name Effect Purity
  • HY-W016735
    Azido-PEG3-alcohol
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 99.77%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation[1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2].
  • HY-136159
    3-Mercaptopropionic acid NHS ester
    3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-140346A
    L-Azidohomoalanine hydrochloride
    L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W591338B
    HO-PEG-CH2COOH (MW 35000)
    HO-PEG-CH2COOH (MW 35000) is a PROTAC linker belonging to the PEG class. HO-PEG-CH2COOH (MW 35000) can be used to synthesize PROTAC molecule[1].
  • HY-153153
    Benzyl-PEG45-alcohol
    Benzyl-PEG45-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-120430
    HO-PEG14-OH
    HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-133321
    N3-PEG24-Hydrazide
    N3-PEG24-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-140722
    Mal-PEG-Succinimidyl Valerate (MW 20000)
    Mal-PEG-Succinimidyl Valerate (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W040239
    m-PEG6-CH2CH2COOH
    m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
  • HY-130524
    Amino-PEG4-CH2COOH
    Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
  • HY-130186
    Methyl propionate-PEG12
    Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-138500
    Mal-PEG12-NH-Boc
    Mal-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-133493
    Folate-PEG3-NHS ester
    Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-140784
    Azido-PEG16-Boc
    Azido-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-138380
    Mal-PEG4-C2-NH2 TFA
    Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-126958
    Biotin-PEG2-acid
    Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
  • HY-130167
    Fmoc-NH-PEG9-CH2CH2COOH
    Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].