1. PROTAC
  2. PROTAC Linker

PROTAC Linker

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linker Related Products (2623):

Cat. No. Product Name Effect Purity
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 99.78%
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 99.50%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation[1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2].
  • HY-W008005
    Amino-PEG4-alcohol
    Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
  • HY-W008574
    TGN-020 98.03%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4].
  • HY-W016735
    Azido-PEG3-alcohol
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-W096128
    Fmoc-NH-PEG3-amide-CH2OCH2COOH
    Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W096116
    PEG2-Cl
    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W096111A
    Trt-PEG4-C2-acid hydrate
    Trt-PEG4-C2-acid (hydrate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W008474
    Boc-NH-PEG2-C2-NH2
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-22335
    Amino-PEG4-C2-amine
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-42776
    NH2-PEG3-C2-NH-Boc
    NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-23408
    Tos-PEG3
    Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].
  • HY-108370
    N33-TEG-COOH
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs)[1].
  • HY-42488
    Hydroxy-PEG3-(CH2)2-Boc
    Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1]. Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
  • HY-23417
    PEG5-Tos 99.05%
    PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-136159
    3-Mercaptopropionic acid NHS ester
    3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • HY-W017772
    Boc-NH-PEG3
    Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
  • HY-40178
    NH2-C4-NH-Boc
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].