Parasite

Cat. No.	Product Name	Effect	Purity

• HY-N0565B

  Doxycycline (hyclate)
  Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

• HY-B1743A

  Puromycin dihydrochloride
  Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis[1].

• HY-B0490

  Hygromycin B
  Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

• HY-66005

  Acetaminophen		99.98%
  Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].

• HY-17589A

  Chloroquine	Inhibitor	99.98%
  Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

• HY-W031727S1

  Hydroxychloroquine-d5
  Hydroxychloroquine-d5 is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• HY-B2031S1

  Pyriproxyfen-d4
  Pyriproxyfen-d4 is the deuterium labeled Pyriproxyfen[1].

• HY-108387

  Morantel citrate	Inhibitor
  Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body[1].

• HY-100595

  Sodium stibogluconate
  Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

• HY-B1916

  Acetylspiramycin
  Acetylspiramycin (Spiramycin B; Spiramycin II; Foromacidin B) is a potent and orally active macrolide antibiotic produced by various Streptomyces species, an acetylated derivative of Spiramycin (HY-100593). Acetylspiramycin is an antimicrobial agent with activity against gram-positive organisms, including Streptococcus pyogenes, S. viridans, Corynebacterium diphtheriae and methicillin-sensitive Staphylococcus aureus. Acetylspiramycin is also a potent antiprotozoal agent that against parasitic infection caused by Cryptosporidium spp[1][2].

• HY-128554S

  N-Desethyl amodiaquine-d5	Inhibitor
  N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

• HY-100586

  Ibuprofen L-lysine
  Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4][5][6][7][8].

• HY-34204

  2'-Hydroxy-4'-methylacetophenone
  2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property[1]. It could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone[2].

• HY-19364

  Ferroquine	Inhibitor	99.68%
  Ferroquine (Ferrochloroquine), a ferrocenyl analogue of Chloroquine, is an antimalarial agent. Ferroquine shows parasiticidal effect on Plasmodium by inducing oxidative stress and the subsequent destruction of the membrane[1].

• HY-N10255

  Trypacidin
  Trypacidin is the conidia-bound metabolite with antiprotozoal activity. Trypacidin has a protective function against phagocytes both in the environment and during the infection process[1].

• HY-17592

  Bithionol	Inhibitor	98.74%
  Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM)[1][2].

• HY-17437A

  Mefloquine hydrochloride	Inhibitor	99.98%
  Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].

• HY-B0244

  Praziquantel	Inhibitor	99.71%
  Praziquantel is a racemic mixture, which is composed of (R)-Praziquantel and (S)- Praziquantel. Praziquantel is safe and has been used for the research of schistosomiasis[1].

• HY-B1282A

  Sulfaquinoxaline sodium salt	Inhibitor
  Sulfaquinoxaline sodium salt is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].

• HY-A0148

  Halofantrine	Inhibitor
  Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2].

• HY-128468

  1,2-Dimyristoyl-sn-glycerol
  1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC[1].

• HY-B0963

  Cloxiquine	Inhibitor
  Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ[1][2].

• HY-B0508

  Ornidazole	Inhibitor	99.74%
  Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.

• HY-B0688

  Dapsone	Inhibitor	99.67%
  Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

• HY-N10899

  Bruceine J	Inhibitor
  Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity[1].

• HY-128554A

  N-Desethyl amodiaquine dihydrochloride	Inhibitor	99.69%
  N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria[1][2].

• HY-N10197

  Pulixin	Inhibitor
  Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM[1].

• HY-B0806S1

  Proguanil-d4
  Proguanil-d4 is the deuterium labeled Proguanil[1]. Proguanil, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[2][3].

• HY-N3075

  Phytol	Inhibitor
  Phytol ((E)​-​Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, possesses promising antischistosomal properties. Phytol has antinociceptive and antioxidant activitiesas well as anti-inflammatory and antiallergic effects. Phytol has antimicrobial activity against Mycobacterium tuberculosis and Staphylococcus aureus[1].

• HY-12639A

  Bephenium (hydroxynaphthoate)	Inhibitor	99.91%
  Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis; B-type AChR activator.

• HY-B0937

  Amprolium	Inhibitor
  Amprolium is a coccidiostat used in poultry, is a thiamine analogue and blocks the thiamine transporter of Eimeria species by blocking thiamine uptake it prevents carbohydrate synthesis.

• HY-18748

  BQR-695	Inhibitor	99.87%
  BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

• HY-N2381

  Menthone	Inhibitor
  Menthone, a monoterpene extracted from plants and Mentha oil with strong antioxidant properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni Infection[1][2].

• HY-W010986

  Fmoc-N-Me-Phe-OH	Inhibitor
  Fmoc-N-Me-Phe-OH is a peptide inhibitor of Malaria Parasite[1].

• HY-P3512

  Iseganan	Inhibitor
  Iseganan is an antimicrobial peptide, shows broad-spectrum anti-bacteria and fungi activity. Iseganan can be used in oral mucositis research[1][2][3].

• HY-N9179

  3′,4′,5′,5,6,7-Hexamethoxyflavone	Inhibitor
  3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL)[1].

• HY-133004

  Fenbutatin oxide	Inhibitor
  Fenbutatin oxide is an organotin acaricide[1].

• HY-N9194

  5-Methoxycanthin-6-one
  5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC50 of 5.44 μg/mL against Ailanthus altissima cells[1][2].

• HY-W016586

  Acivicin	Inhibitor
  Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

• HY-B0945

  Nitromide	Inhibitor
  Nitromide is an anti-parasitic agent.

• HY-109077S

  Tigolaner-d4
  Tigolaner-d4 is deuterium labeled Tigolaner. Tigolaner is a GABA antagonist that regulates chloride channel. Tigolaner is an antiparasitic agent[1].

• HY-136450S1

  Triclabendazole sulfoxide-13C,d3	Inhibitor
  Triclabendazole sulfoxide-13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

• HY-B0817S

  Pyridaben-d13
  Pyridaben-d13 is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].

• HY-B1322AS

  Amodiaquine-d10	Inhibitor
  Amodiaquine-d10 is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

• HY-B0827S

  Dinotefuran-d3
  Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].

• HY-145431

  BPTF-IN-1	Inhibitor
  BPTF-IN-1 (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. BPTF-IN-1 shows to be selective for BPTF over BRD4 bromodomain. BPTF-IN-1 shows antimalarial activity[1].

• HY-121054

  Chalcone
  Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities[1].

• HY-B1282S

  Sulfaquinoxaline-d4	Inhibitor
  Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].

• HY-B1282

  Sulfaquinoxaline	Inhibitor
  Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].

• HY-136448

  SJ000025081	Inhibitor
  SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii[1].

• HY-B1244

  Dimetridazole	Inhibitor
  Dmetridazole (1,2-Dimethyl-5-nitroimidazole), a nitroimidazole-based antibiotic, combats protozoan infections[1].

• HY-152614

  Antimalarial agent 19	Inhibitor
  Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine[1].

• HY-17589

  Chloroquine phosphate	Inhibitor	99.96%
  Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

• HY-N6697

  Aflatoxin G1		99.94%
  Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops[1][2].

• HY-146769

  Antimalarial agent 11	Inhibitor
  Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

• HY-B0978S1

  Diethyltoluamide-d7
  Diethyltoluamide-d7 is the deuterium labeled Diethyltoluamide[1]. Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects[2].

• HY-N6696

  Aflatoxin B2		99.41%
  Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

• HY-119931

  2-Hydroxychalcone		98.80%
  2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

• HY-N2590

  Lupenone	Inhibitor
  Lupenone, isolated from Musa basjoo, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity[1][2].

• HY-B1751F

  Quinidine gluconic acid	Inhibitor
  Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research[1][2][3][4].

• HY-N1453

  Hypocrellin B	Inhibitor	99.61%
  Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

• HY-116448

  Metaflumizone	Inhibitor
  Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker[1].

• HY-W268334

  1,2,3,4-Tetrahydronorharman-1-one	Inhibitor
  1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge[1].

• HY-B0508S

  Ornidazole-d5	Inhibitor
  Ornidazole-d5 is deuterium labeled Ornidazole.

• HY-12651

  Primaquine diphosphate	Inhibitor
  Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale[1][2].

• HY-111817

  ACT-451840	Inhibitor
  ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial[1][2][3].

• HY-B1207S

  Urethane-d5	Inhibitor
  Urethane-d5 is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].

• HY-135666

  DHODH-IN-8	Inhibitor
  DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity[1].

• HY-78131

  Ibuprofen		99.95%
  Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

• HY-B0986

  Hexylresorcinol	Inhibitor
  Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5].

• HY-10969

  Obatoclax Mesylate	Inhibitor
  Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2[1][2]. Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity[3][4].

• HY-14590

  Kaempferol	Inhibitor	99.67%
  Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].

• HY-B1198S

  Piperonyl butoxide-d9	Inhibitor
  Piperonyl butoxide-d9 is the deuterium labeled Piperonyl butoxide. Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.

• HY-118607

  VU041	Inhibitor	99.64%
  VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC50 values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC50 of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function[1].

• HY-N0402S

  Artemether-d3	Inhibitor
  Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

• HY-16974

  Afoxolaner	Inhibitor	99.95%
  Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

• HY-117386

  Methoxyfenozide	Inhibitor
  Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively).

• HY-B0879A

  Suramin sodium salt	Inhibitor
  Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5]. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].

• HY-B1094

  Aklomide	Inhibitor
  Aklomide is used to fight disease, parasites and insects that infest poultry.

• HY-13735A

  Quinacrine dihydrochloride	Inhibitor
  Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].

• HY-114899

  Azamethiphos
  Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase (AChE) inhibition[1].

• HY-B1093

  Fenchlorphos	Inhibitor	99.89%
  Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction[1][2].

• HY-N0337

  Eugenol	Inhibitor	99.30%
  Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.

• HY-W009109

  Antimalarial agent 1	Inhibitor	99.14%
  Antimalarial agent 1 is a potent antimalarial drug[1].

• HY-146049

  Antitrypanosomal agent 4	Inhibitor
  Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively[1].

• HY-115364S

  Parbendazole-d3	Inhibitor
  Parbendazole-d3 is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

• HY-137141

  16-Keto Aspergillimide	Inhibitor
  16-Keto Aspergillimide (SB202327) is an anthelmintic agent isolated from Aspergillus strain IMI 337664[1].

• HY-N5017

  Isochondrodendrine	Inhibitor
  Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum[1].

• HY-B1851S

  Hexythiazox-d11	Inhibitor
  Hexythiazox-d11 is deuterium labeled Hexythiazox. Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. Hexythiazox is widely used for chemical control of mites on cotton, fruits and vegetables. Hexythiazox is harmless to mammals and has no effect on beneficial insects and predators of mites[1][2].

• HY-B1896

  Piperaquine	Inhibitor
  Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].

• HY-113607

  Asimicin	Inhibitor
  Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].

• HY-146042

  Antiparasitic agent-4	Inhibitor
  Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC50 = 18.97 μM)[1].

• HY-18684

  SIBA	Inhibitor	99.66%
  SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].

• HY-B0935

  Benzyl benzoate	Inhibitor
  Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions[1][2][3].

• HY-16779

  Fosravuconazole	Inhibitor	98.48%
  Fosravuconazole (BMS-379224), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].

• HY-76204S

  Glycine ethyl ester-13C hydrochloride	Inhibitor
  Glycine ethyl ester-13C (hydrochloride) is a 13C-labeled Mebendazole.

• HY-N0565

  Doxycycline
  Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

• HY-B1221

  Flufenamic acid	Inhibitor	99.85%
  Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

• HY-126937

  Ivermectin B1a	Inhibitor
  Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310)[1]. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[2].

• HY-D1532

  DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
  DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].

• HY-115550

  Chalcone 4 hydrate	Inhibitor
  Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria[1].

• HY-W031727S

  Hydroxychloroquine-d4-1 sulfate	Inhibitor
  Hydroxychloroquine-d4-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

• HY-146043

  Antiparasitic agent-5	Inhibitor
  Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC50 = 6.78 μM)[1].

• HY-17036

  Naphthoquine phosphate	Inhibitor
  Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of P. falciparum to Chloroquine[1][2].

• HY-16779B

  Fosravuconazole L-lysine ethanolate	Inhibitor	99.59%
  Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].

• HY-N6700

  Aflatoxin M2
  Aflatoxin M2 is a major metabolite of Aflatoxin B1. Aflatoxin M2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

• HY-130993

  Isatropolone A	Inhibitor
  Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against Leishmania donovani with an IC50 of 0.5 μM[1].

• HY-B0879

  Suramin	Inhibitor
  Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5].Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].

• HY-B1881S

  Pirimiphos-methyl-d6	Inhibitor
  Pirimiphos-methyl-d6 is the deuterium labeled Pirimiphos-methyl. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].

• HY-N2023A

  Thalifendine chloride	Inhibitor
  Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activities against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively[1][2].

• HY-17598S

  Rafoxanide 13C6	Inhibitor
  Rafoxanide 13C6 is a labeled Rafoxanide (HY-17598). Rafoxanide is a salicylanilide used as an antiparasitic agent[1].

• HY-143409

  Antimalarial agent 10
  Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is[1].

• HY-133108

  Azadirachtin B	Inhibitor	99.12%
  Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

• HY-B1636

  Dithiazanine iodide	Inhibitor	99.91%
  Dithiazanine iodide is an effective broad-spectrum anthelmintic. Dithiazanine iodide can be used for the research of trichuriasis, strongyloidiasis, enterobiasis, ascariasis, and hookworm infection. Dithiazanine iodide is also a cyanine dye[1][2].

• HY-W020111

  7-Chloro-4-(piperazin-1-yl)quinoline	Inhibitor
  7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].

• HY-B1118A

  Secnidazole hemihydrate	Inhibitor
  Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

• HY-B0744

  Eflornithine
  Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

• HY-N0540

  Cynaroside	Inhibitor	99.19%
  Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities[1][3][4][5].

• HY-N6816

  Ludaconitine	Inhibitor
  Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL[1].

• HY-116387

  WR99210	Inhibitor	98.72%
  WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].

• HY-121410

  Narasin	Inhibitor
  Narasin is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial and anticancer activity[1].

• HY-17596A

  Closantel sodium	Inhibitor	99.69%
  Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing[1][2].

• HY-148180

  Antimycobacterial agent-4	Inhibitor
  Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line[1][2].

• HY-10373

  Trimetrexate	Inhibitor	99.22%
  Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5].

• HY-W011035

  Dodecamethylpentasiloxane	Inhibitor
  Dodecamethylpentasiloxane is a component of siloxanes and can be used as silicone oil. Dodecamethylpentasiloxane exhibits insecticidal activity against bed bug[1][2].

• HY-B0497BS

  Niclosamide-13C6 monohydrate
  Niclosamide-13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].

• HY-145079

  Bunamidine hydrochloride		99.54%
  Bunamidine hydrochloride is a veterinary anti-platyhelmintic agent used for Echinococcus granulosus and Taenia hydatigena[1].

• HY-135810

  Cletoquine	Inhibitor
  Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

• HY-103033

  T.cruzi-IN-1	Inhibitor	99.21%
  T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease[1].

• HY-N0352

  Tuberostemonine	Inhibitor
  Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR)[1].

• HY-15597

  Salinomycin
  Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells[1][2][3].

• HY-B0177

  Tinidazole		99.87%
  Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa[1].

• HY-N1621

  1-Deacetylnimbolinin B	Inhibitor
  1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties[1].

• HY-122818

  bpV(phen) trihydrate	Inhibitor
  bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].

• HY-121429

  Dymanthine
  Dymanthine is an anthelminthic. Dymanthine has the potential for the research of multiple intestinal helmintic infestations[1][2].

• HY-146747

  Antifungal agent 26
  Antifungal agent 26, a Pradimicin A derivative, shows antifungal, antiviral, and antiparasitic activities through binding to d-mannose (Man)-containing glycans of pathogenic species[1].

• HY-13832S3

  cis-Atovaquone-d4	Inhibitor
  cis-Atovaquone-d4 is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

• HY-B0837

  Emamectin Benzoate	Inhibitor
  Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate[1][2].

• HY-135578

  Artelinic acid	Inhibitor	98.10%
  Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes[1][2].

• HY-B1327A

  Chlortetracycline
  Chlorotetracycline (7-Chlorotetracycline) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

• HY-B0273

  Sulfadiazine	Inhibitor	99.86%
  Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research[1][2].

• HY-12519

  Oltipraz		99.74%
  Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

• HY-N10443

  Mammea A/BA	Inhibitor
  Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].

• HY-19594

  Teclozan	Inhibitor	99.75%
  Teclozan (WIN 13146) is an antiprotozoal agent, class in benzylamine derivatives. Teclozan intervenes in the phospholipid metabolism preventes the formation of arachidonic acid. Teclozan acts in the intestinal lumen being effective in Anti-G. intestinalis. Teclozan can be used for the research of protozoan infections[1][2].

• HY-128971

  LHVS	Inhibitor
  LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC50 of 10 μM[1][2][3].

• HY-146745

  Antileishmanial agent-5	Inhibitor
  Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC50 values of 0.68 μM and 0.83 μM, respectively[1].

• HY-10411

  AZ960	Inhibitor
  AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.

• HY-B2157S

  Robenidine-d8 hydrochloride	Inhibitor
  Robenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.

• HY-N8213

  Rapanone	Inhibitor	99.20%
  Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].

• HY-N0325S3

  DL-Methionine-d3	Inhibitor
  DL-Methionine-d3 is the deuterium labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3][4].

• HY-B0846

  Dimethomorph
  Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 µM[1][2][3].

• HY-114029

  Ep vinyl quinidine	Inhibitor
  Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine. Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine can be used for malaria research[1][2][3].

• HY-N0531

  Filixic acid ABA	Inhibitor
  Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD50 of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm[1].

• HY-16438

  RRx-001	Inhibitor	99.71%
  RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity[1]. RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α[2]. RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity[3].

• HY-B0820

  Nitenpyram		99.20%
  Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals[1][2].

• HY-W052512

  Antitrypanosomal agent 1	Inhibitor
  Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].

• HY-N7648

  Atherosperminine	Inhibitor
  Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC50 of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis[1].

• HY-115972

  Anti-Trypanosoma cruzi agent-2	Inhibitor
  Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC50 = 0.51 µM) and INC-5 epimastigote form (IC50 = 3.06 µM), posseses anti-T. gondii activity[1].

• HY-W019773S

  Albendazole sulfone-d7	Inhibitor
  Albendazole sulfone-d7 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].

• HY-N1667

  2',4'-Dihydroxy-6'-Methoxyacetophenone	Inhibitor
  2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the treatment of malaria[1].

• HY-N4302

  Monensin
  Monensin is a naturally occurring bioactive ionophore produced by Streptomyces spp. Monensin can bind protons and monovalent cations. Monensin exhibits a broad spectrum activity against opportunistic pathogens of humans in both drug sensitive and resistant strains. Monensin also induces apoptosis in multiple cancer cell lines[1][2].

• HY-115725

  Antileishmanial agent-1	Inhibitor
  Antileishmanial agent-1 exhibits the activity against L. amazonensis promastigotes (IC50 = 15.52 μM) and intracellular amastigotes (IC50 = 4.10 μM).

• HY-N3754

  Dihydropinosylvin monomethyl ether	Inhibitor
  Dihydropinosylvin monomethyl ether is a natrual compound with nematicidal activity. Dihydropinosylvin monomethyl ether can inhibit pine wood nematodes infection[1].

• HY-17597

  Febantel	Inhibitor	99.36%
  Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.

• HY-B1322

  Amodiaquine dihydrochloride dihydrate	Inhibitor	99.73%
  Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

• HY-B0744D

  L-Eflornithine monohydrochloride
  L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1[1].

• HY-17470

  Mizoribine		99.98%
  Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant[1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively[2].

• HY-B1120S

  Temephos-d12
  Temephos-d12 is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].

• HY-B0803

  Lumefantrine	Inhibitor	98.41%
  Lumefantrine is an antimalarial drug, used in combination with Artemether.

• HY-12643

  Eprinomectin	Inhibitor	98.03%
  Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity.

• HY-P3461

  Argadin	Inhibitor
  Argadin is a cyclopentapeptide chitinase inhibitor. Argadin inhibits chitinase B (ChiB) with a Ki value of 20 nM. Argadin can be used for the research of fungicid and insecticid[1][2].

• HY-B0836

  λ-Cyhalothrin	Inhibitor	99.21%
  λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system[1].

• HY-147806

  Antiparasitic agent-8	Inhibitor
  Antiparasitic agent-8 (Compound 9) is an antiparasitic agent against Hymenolepis nana with low cytotoxicity[1].

• HY-110137A

  Furamidine	Inhibitor
  Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent[1][2][3].

• HY-B0937A

  Amprolium hydrochloride	Inhibitor	99.11%
  Amprolium hydrochloride is a coccidiostat used in poultry, is a thiamine analogue and blocks the thiamine transporter of Eimeria species by blocking thiamine uptake it prevents carbohydrate synthesis.

• HY-151470

  Chitinase-IN-5	Inhibitor
  Chitinase-IN-5 (8i) is a potent chitinase OfChi-h inhibitor with an IC50 value of 0.051 μM. Chitinase-IN-5 shows good insecticidal activity, it can be used for the research of green pest control and management[1].

• HY-N2230

  N-p-trans-Coumaroyltyramine	Inhibitor	98.78%
  N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2].

• HY-19910

  Acoziborole	Inhibitor	99.94%
  Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 µg/mL[1].

• HY-B0537C

  Pentamidine dimesylate	Inhibitor
  Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• HY-136450S

  Triclabendazole sulfoxide-d3	Inhibitor
  Triclabendazole sulfoxide-d3 is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

• HY-151484

  Anti-infective agent 4	Inhibitor
  Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1].

• HY-128354

  CWHM-1552	Inhibitor
  CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively[1].

• HY-13557

  Ascomycin	Inhibitor
  Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

• HY-13582

  Carbendazim		99.81%
  Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].

• HY-119826

  Quinfamide
  Quinfamide is an antiamebic agent. Quinfamide has the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis[1].

• HY-13702

  Nilutamide	Inhibitor	98.07%
  Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties[1][4].

• HY-135811S1

  Desethyl chloroquine-d5	Inhibitor
  Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

• HY-108718

  G-418
  G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

• HY-12912

  KDU691	Inhibitor	99.56%
  KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites[1].

• HY-B0887S1

  Permethrin-d9	Inhibitor
  Permethrin-d9 is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

• HY-N1480S2

  (-)-Fucose-13C-2
  (-)-Fucose-13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

• HY-111757

  ABBV-4083	Inhibitor
  ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1].

• HY-N4307

  Laetanine	Inhibitor
  Laetanine, a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity[1].

• HY-N6742

  Borrelidin	Inhibitor
  Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4].

• HY-138502

  Melarsomine	Inhibitor
  Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections[1][2].

• HY-B0744B

  Eflornithine hydrochloride hydrate	Inhibitor
  Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women[1].

• HY-B1400

  Diiodohydroxyquinoline
  Diiodohydroxyquinoline is a topical therapeutic agent, with satisfactory antibacterial properties.

• HY-151561

  WM382	Inhibitor
  WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC50 values of 1.4 nM and 0.03 nM, respectively. WM382 has robust in vivo efficacy at multiple stages of the malaria parasite life cycle and an excellent resistance profile[1][2][3].

• HY-B1751S

  Quinidine-d3	Inhibitor
  Quinidine-d3 is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

• HY-B1751C

  Quinine hydrobromide	Inhibitor
  Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine hydrobromide can be used for malaria research[1][2][3].

• HY-B0318S

  Metronidazole-13C2,15N2	Inhibitor
  Metronidazole-13C2,15N2 is the 13C-labeled and 15N-labeled Metronidazole. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.

• HY-108024A

  Ganaplacide hydrochloride	Inhibitor
  Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite[1][2].

• HY-B0803S

  Lumefantrine-d18	Inhibitor
  Lumefantrine-d18 is the deuterium labeled Lumefantrine, which is an antimalarial drug.

• HY-B0439S1

  Sulfadoxine D3	Inhibitor
  Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

• HY-B1896B

  Piperaquine tetraphosphate tetrahydrate	Inhibitor
  Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin[1][2].

• HY-14749AS

  Pyronaridine-d4 tetraphosphate
  Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

• HY-B1120

  Temephos	Inhibitor
  Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae.

• HY-103353A

  SID 26681509 quarterhydrate	Inhibitor
  SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G[1].

• HY-120924

  BRD9185
  BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

• HY-117015

  Purfalcamine	Inhibitor	99.71%
  Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2].

• HY-N6251

  Cratoxylone	Inhibitor
  Cratoxylone, isolated from the bark of Cratoxylum Cochinchinense, possesses antiplasmodial activity[1][2].

• HY-B0413S

  Fenbendazole-d3	Inhibitor	99.46%
  Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

• HY-139672

  BRD5018	Inhibitor
  BRD5018 is an antimalarial agent.

• HY-12651S

  Primaquine-d3 diphosphate	Inhibitor
  Primaquine-d3 (diphosphate) is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale[1][2].

• HY-136240

  Tioxazafen	Inhibitor
  Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton[1].

• HY-128554S1

  N-Desethyl amodiaquine-d5 dihydrochloride	Inhibitor
  N-Desethyl amodiaquine-d5 (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

• HY-B2031

  Pyriproxyfen	Inhibitor	99.70%
  Pyriproxyfen is a juvenile hormone analog, preventing larvae from developing into adulthood and thus rendering them unable to reproduce.

• HY-17589B

  Chloroquine dihydrochloride	Inhibitor
  Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

• HY-B1072A

  D-Phenothrin	Inhibitor
  D-Phenothrin ((-)-trans-Phenothrin), an orally active Type II synthetic pyrethroid, is widely used to kill insects, mosquitoes, and human lice. D-Phenothrin is also used in veterinary medicine to control insect pests on animals and protect agricultural crops[1].

• HY-145812

  CRK12-IN-1	Inhibitor
  CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively)[1].

• HY-138502A

  Melarsomine dihydrochloride	Inhibitor
  Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections[1][2].

• HY-144298

  HDAC1-IN-4	Inhibitor
  HDAC1-IN-4 (JX34) is a potent Plasmodium falciparum HDAC1 inhibitor shows antimalarial activity (IC50 < 5 nM) and lower cytotoxicity[1].

• HY-N1133

  trans-Methylisoeugenol
  trans-Methylisoeugenol is an insect chemosterilant isolated from Acorus calamus L[1].

• HY-B1953

  Thiacloprid	Inhibitor
  Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].

• HY-145964

  INE963	Inhibitor	98.84%
  INE963 is a potent and fast-acting blood-stage antimalarial agent, with an EC50s of 3-6 nM. INE963 is potential for single-dose cures in uncomplicated malaria[1].

• HY-118865S

  Piperaquine-d6 tetraphosphate	Inhibitor
  Piperaquine-d6 (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

• HY-16973

  Fluralaner	Inhibitor	99.97%
  Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

• HY-15311

  Avermectin B1	Inhibitor	98.00%
  Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy[1][2][4].

• HY-P2274

  Argifin	Inhibitor
  Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

• HY-147856

  Antileishmanial agent-11	Inhibitor
  Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively[1].

• HY-B1302

  Quinidine hydrochloride monohydrate	Inhibitor
  Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.

• HY-B1370S

  Hydroxychloroquine-d4 sulfate	Inhibitor
  Hydroxychloroquine-d4 (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

• HY-N5060

  Estragole		99.18%
  Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability[1]. Estragole displays anti-toxoplasma activity[2].

• HY-120154

  Palitantin	Inhibitor
  Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis[1].

• HY-N0769

  Isopimpinellin	Inhibitor	99.69%
  Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect[1].

• HY-N10743

  Pipercide	Inhibitor
  Pipercide is an amide of piper nigrum fruits. Pipercide has larvicidal activity to mosquito. Pipercide acts on the nervous system and induces repetitive discharge on the central nerve cord. Pipercide can be used as an insecticide[1].

• HY-B1111S1

  Amitraz-d3	Inhibitor
  Amitraz-d3 is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

• HY-B0223S

  Albendazole-d3	Inhibitor	98.28%
  Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations[1].

• HY-147537

  Antileishmanial agent-9	Inhibitor
  Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC50 = 40.1 μM)[1].

• HY-135810A

  Cletoquine oxalate	Inhibitor	99.76%
  Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

• HY-15310

  Ivermectin	Inhibitor
  Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import[1][2][3][4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[5].

• HY-B0221

  Amphotericin B
  Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

• HY-N0565A

  Doxycycline hydrochloride
  Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

• HY-16938

  5'-Methylthioadenosine
  5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

• HY-144297

  HDAC1-IN-3
  HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites[1].

• HY-77813

  Benzyl isothiocyanate		99.29%
  Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

• HY-12784

  Cycloguanil	Inhibitor
  Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

• HY-101000

  Clazuril	Inhibitor
  Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle[1].

• HY-114415

  AWZ1066S	Inhibitor	98.64%
  AWZ1066S is a highly potent, specific and orally active anti-Wolbachia agent with EC50 value of 121 nM. AWZ1066S also is a weak CYP2C9 inhibitor and a weak CYP3A4 inducer with IC50 values of 9.7 μM and 37 uM, respectively. AWZ1066S can be used for the research of tropical diseases such as Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) [1].

• HY-141621

  ACT-606559	Inhibitor
  ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial[1].

• HY-B0537AS

  Pentamidine-d4 dihydrochloride	Inhibitor
  Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• HY-N11031

  Z-Antiepilepsirine	Inhibitor
  Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC50 value of 27 µM for W2 strain of Plasmodium falciparum[1].

• HY-119046

  SNX-0723	Inhibitor	99.15%
  SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM[1].

• HY-B0294

  Flubendazole	Inhibitor	99.79%
  Flubendazole is a safe and efficacious anthelmintic drug, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

• HY-B1370A

  (S)-Hydroxychloroquine	Inhibitor
  (S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine[1]. Hydroxychloroquine, a synthetic antimalarial drug, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• HY-N7634

  Tectol	Inhibitor	98.32%
  Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

• HY-12785

  Albendazole sulfoxide	Inhibitor
  Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1].

• HY-N9343

  Kulactone	Inhibitor
  Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB)[1][2].

• HY-N6009

  8-Deoxygartanin	Inhibitor	99.24%
  8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE)[1]. 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum[2]. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM[3].

• HY-W026467

  MMV665916	Inhibitor
  MMV665916, a quinazolinedione derivative, is an antimalarial agent. MMV665916 displays antiplasmodial activity against P. falciparum FcB1 strain with EC50 value of 0.4 µM and presents the high selectivity index (SI>250)[1].

• HY-B0221A

  Amphotericin B trihydrate
  Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity[1][2].

• HY-17437

  Mefloquine	Inhibitor
  Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].

• HY-N1944

  Nerolidol	Inhibitor
  Nerolidol is a natural membrane-active sesquiterpene, with antitumor, antibacterial, antifungal and antiparasitic activity[1].

• HY-N10769

  Atanine	Inhibitor
  Atanine is an alkaloid with antiparasitic activity. Atanine can be isolated from medicinal plant, Evodia rutaecarpa[1].

• HY-16730

  Sarolaner	Inhibitor	99.05%
  Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata[1].

• HY-119419S

  Pirimicarb-d6
  Pirimicarb-d6 is the deuterium labeled Diuron. Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male

• HY-121325

  Fervenulin	Inhibitor
  Fervenulin has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively[1].

• HY-N0565C

  Doxycycline calcium
  Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].

• HY-N6961

  Lapachol	Inhibitor
  Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae)[1]. Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities[2].

• HY-B1221S1

  Flufenamic acid-13C6	Inhibitor
  Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

• HY-107566

  Conessine	Inhibitor
  Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

• HY-12651A

  Primaquine	Inhibitor
  Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria[1][2].

• HY-17506A

  Azithromycin hydrate
  Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

• HY-B1751D

  Quinidine sulfate dihydrate	Inhibitor
  Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research[1][2][3][4].

• HY-12640

  Pyrantel pamoate	Inhibitor	99.98%
  Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

• HY-128554

  N-Desethyl amodiaquine	Inhibitor
  N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2].

• HY-147971

  Anticancer agent 75	Inhibitor
  Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial[1].

• HY-145704

  Antimalarial agent 8	Inhibitor
  Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria[1].

• HY-115584S

  Lufenuron-13C6	Inhibitor
  Lufenuron-13C6 is a 13C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods[1][2].

• HY-78131C

  Ibuprofen sodium		99.89%
  Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

• HY-14749A

  Pyronaridine tetraphosphate	Inhibitor
  Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[1][2].

• HY-B1344

  Oxantel pamoate	Inhibitor	99.97%
  Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms.

• HY-B1004

  Dinitolmide	Inhibitor	99.48%
  Dinitolmide (Zoalene), a fodder additive for poultry, has anti-coccidial effect. Dinitolmide can be used to prevent infections induced by Eimeria, such as Eimeria tenella, Eimeria necatrix, Eimeria brunette, and so on[1].

• HY-117684

  Cabamiquine	Inhibitor	98.33%
  Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].

• HY-17035

  Doramectin	Inhibitor	98.96%
  Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model[1][2][3].

• HY-N1451

  Betulonic acid	Inhibitor
  Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities[2][1][3][4].

• HY-Q40175

  Antitrypanosomal agent 9	Inhibitor
  Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

• HY-N10303

  Withangulatin A	Inhibitor
  Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function[1].

• HY-125729

  Ivermectin B1b	Inhibitor
  Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

• HY-100593

  Spiramycin	Inhibitor	99.19%
  Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached[1][2].

• HY-17596S

  Closantel-13C6	Inhibitor
  Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

• HY-B1953S

  Thiacloprid-d4
  Thiacloprid-d4 is the deuterium labeled Thiacloprid[1]. Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].

• HY-17592A

  Bithionol (sulfoxide)	Inhibitor	98.65%
  Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection[1][2][5].

• HY-119419

  Pirimicarb	Inhibitor
  Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an acaricide[1].

• HY-108640

  HLI373	Inhibitor
  HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].

• HY-B1315

  Carbaryl		99.95%
  Carbaryl is used chiefly as an insecticide[1].

• HY-12639

  Bephenium	Inhibitor
  Bephenium is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis; B-type AChR activator.

• HY-B1315S

  Carbaryl-d3
  Carbaryl-d3 is the deuterium labeled N6-(carboxymethyl)-L-lysine[1].

• HY-143218

  TPE-MI		98.54%
  TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin treatment of the malaria parasitesPlasmodium falciparum [1][2].

• HY-N7141

  Spiramycin I	Inhibitor	98.09%
  Spiramycin I is a macrolide antibiotic and antiparasitic[1].

• HY-B1751A

  Quinidine Monosulfate	Inhibitor
  Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine Monosulfate can be used for malaria research[1][2][3][4].

• HY-125159

  Derquantel	Inhibitor
  Derquantel is a potent anthelmintic. Derquantel causes flaccid paralysis and expulsion of nematodes[1].

• HY-17008

  Toltrazuril (sulfone)	Inhibitor	99.34%
  Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry[1][2].

• HY-15537

  Tilbroquinol	Inhibitor	98.33%
  Tilbroquinol is an orally active antiparasite agent, can be used in study of amoebiasis. tilbroquinol is also used against Vibrio cholera[1].

• HY-12651AS

  Primaquine-13C,d3
  Primaquine-13C,d3 is the deuterium and 13C labeled Primaquine[1].

• HY-B1322A

  Amodiaquine	Inhibitor
  Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

• HY-N0498

  Nitidine chloride	Inhibitor	99.61%
  Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

• HY-B0094

  Artemisinin	Inhibitor
  Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

• HY-148035

  Plm IV inhibitor-2	Inhibitor
  Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites[1].

• HY-B1118S

  Secnidazole-d6	Inhibitor
  Secnidazole-d6 is the deuterium labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research[1].

• HY-D0143A

  Quinine dihydrochloride	Inhibitor
  Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

• HY-151195

  20S Proteasome-IN-4
  20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT)[1].

• HY-126323

  TCMDC-135051	Inhibitor	99.41%
  TCMDC-135051 is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1].

• HY-116433

  Nequinate	Inhibitor
  Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

• HY-B1177

  Crotamiton	Inhibitor	98.32%
  Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic.

• HY-17596

  Closantel	Inhibitor
  Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2].

• HY-B1336

  Furazolidone
  Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.

• HY-N6950

  Hederacolchiside A1	Inhibitor
  Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

• HY-B0244S

  Praziquantel-d11	Inhibitor
  Praziquantel-d11 is the deuterium labeled Praziquantel, which is an anthelmintic.

• HY-B1143

  Broxaldine		99.50%
  Broxaldine (Brobenzoxaldine) is an antiprotozoal agent. Broxaldine inhibits Clostridium difficile with a MIC value of 4 µM, and has antifungal effects[1][2].

• HY-19285A

  Sulfaclozine sodium	Inhibitor	99.20%
  Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)[1].

• HY-132930

  TCMDC-136230	Modulator
  TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

• HY-N7516

  4'-Hydroxy-2,4-dimethoxychalcone	Inhibitor	99.76%
  4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].

• HY-B0439

  Sulfadoxine	Inhibitor	99.44%
  Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

• HY-12987

  Pimozide		99.88%
  Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

• HY-N10263

  Palmarumycin C3
  Palmarumycin C3 is a spirobisnaphthalene compound isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. Palmarumycin C3 exhibits stronger antimicrobial and antioxidant activities[1].

• HY-106866

  Bulaquine	Inhibitor
  Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].

• HY-N0054

  Osthole	Inhibitor	99.95%
  Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

• HY-A0106

  Levamisole	Inhibitor	99.96%
  Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].

• HY-N0924

  (±)-Stylopine
  (±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities[1][2].

• HY-12987S2

  Pimozide-d4-1	Inhibitor
  Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3][4].

• HY-107483S

  Cambendazole-d7
  Cambendazole-d7 is the deuterium labeled Cambendazole[1].

• HY-115905

  Antimalarial agent 9	Inhibitor
  Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC50-0.14 μM) and MDR strain (IC50-0.41 μM) with minimal cytotoxicity and high selectivity[1].

• HY-150066

  Antimalarial agent 16	Inhibitor
  Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].

• HY-115721

  Antimalarial agent 2	Inhibitor
  Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

• HY-145379

  Miaosporone A
  Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells[1].

• HY-B0486

  Lonidamine		99.44%
  Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3].

• HY-114489B

  Haemanthamine hydrochloride	Inhibitor
  Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

• HY-B1071

  Lasalocid
  Lasalocid (Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) is an antibacterial agent and a coccidiostat, used in the feed additives

• HY-B1437

  Acetarsol	Inhibitor	99.87%
  Acetarsol (Stovarsol) is a potent and orally active anti-infective agent. Acetarsol shows anti-parasite activity. Acetarsol has the potential for the research of proctitis[1].

• HY-136440S

  Hydroxymetronidazole-d4	Inhibitor
  Hydroxymetronidazole-d4 is the deuterium labeled Hydroxymetronidazole. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle[1].

• HY-B0744A

  Eflornithine hydrochloride
  Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

• HY-N1581

  Quassin	Inhibitor
  Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].

• HY-13666S

  Levamisole-d5 hydrochloride	Inhibitor
  Levamisole-d5 (hydrochloride) is the deuterium labeled Levamisole hydrochloride. Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV[1][2].

• HY-B1751E

  Quinidine polygalacturonate	Inhibitor
  Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4].

• HY-100184

  DSM265	Inhibitor	99.72%
  DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].

• HY-B0935S

  Benzyl benzoate-d5
  Benzyl benzoate-d5 is the deuterium labeled Benzyl benzoate[1]. Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions[2][3][4].

• HY-N0325S4

  DL-Methionine-d4	Inhibitor
  DL-Methionine-d4 is the deuterium labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3].

• HY-121477

  Resorantel	Inhibitor	99.80%
  Resorantel is an anthelmintic[1]. Resorantel is used in the research of paramphistomiasis in cattle and sheep and has also been used for the research of G. aegypticus[2].

• HY-148429

  Antimalarial agent 17	Inhibitor
  Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides[1].

• HY-17598

  Rafoxanide	Inhibitor
  Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide can be used for the control of infestation with Hemonchus species and Fasciola species in sheep and cattle and Estrus ovis in sheep. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide eliminates 91-99% of the mature flukes and 50-90% of the younger flukes in ruminants[1][2][3].

• HY-B0887S

  Permethrin-d5	Inhibitor
  Permethrin-d5 (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation[1][2].

• HY-N4238

  Dehydrocorydaline nitrate	Inhibitor	99.90%
  Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

• HY-18062S

  Pyrimethamine-d3
  Pyrimethamine-d3 is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR)[1][2].

• HY-135811S

  Desethyl chloroquine-d4	Inhibitor
  Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

• HY-17439

  Salinomycin sodium salt
  Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells[1][2][3].

• HY-N2848

  α-Lapachone		99.65%
  α-Lapachone shows trypanocidal activity[1].

• HY-136307S

  Tizoxanide-d4 glucuronide	Inhibitor
  Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

• HY-151133

  Antiparasitic agent-9	Inhibitor
  Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite[1].

• HY-132931

  TCMDC-125457	Modulator
  TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.

• HY-W010254

  4′-Hydroxy-2′-methylacetophenone	Inhibitor	98.57%
  4′-Hydroxy-2′-methylacetophenone, an aroma compound of red wines, is isolated from cv. Bobal grape variety. 4′-Hydroxy-2′-methylacetophenone has ciliate toxicity. 4′-Hydroxy-2′-methylacetophenone inhibits the growth of T. pyriformis, with an IC50 of 0.65 mM[1][2].

• HY-145912

  RYL-552S	Inhibitor
  RYL-552S kills drug-resistant strains of Plasmodium falciparum. RYL-552S can efficiently kill asexual blood-stage parasites in vitro[1].

• HY-151148

  Trypanothione synthetase-IN-1
  Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].

• HY-B1548

  Benznidazol	Inhibitor	99.75%
  Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2].

• HY-B0956

  Paromomycin sulfate	Inhibitor
  Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3].

• HY-123601

  DHQZ 36	Inhibitor
  DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].

• HY-115364

  Parbendazole	Inhibitor
  Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

• HY-18715

  Ornidazole (Levo-)	Inhibitor	98.36%
  Ornidazole Levo- is the levo-isomer of Ornidazole. Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole Levo- is the less active isomer.

• HY-N6698

  Aflatoxin G2
  Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1].

• HY-N0193S

  Artesunate-d3	Inhibitor
  Artesunate-d3 is the deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

• HY-N2795

  9-Hydroxycalabaxanthone	Inhibitor
  9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM)[1].

• HY-113542

  Blasticidin A
  Blasticidin A ((+)-Blasticidin A) is an inhibitor of Aflatoxin production by Aspergillus parasiticus. Blasticidin A almost completely inhibits Aflatoxin production at 0.5 μM[1]. Blasticidin A is a potent antibiotic produced by Streptomyces, inhibits Aflatoxin production without strong growth inhibition toward Aflatoxin-producing fungi[2].

• HY-B0537A

  Pentamidine dihydrochloride	Inhibitor
  Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• HY-147940

  TbPTR1 inhibitor 1	Inhibitor
  TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].

• HY-W019773S1

  Albendazole sulfone-d3	Inhibitor
  Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.

• HY-100358

  AQ-13 dihydrochloride	Inhibitor	98.31%
  AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against drug-resistant strains of Plasmodium falciparum.

• HY-N0194

  Asiatic acid	Inhibitor
  Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid has the potential for skin cancer treatment[1]. Asiatic acid also has anti-inflammatory activities[2].

• HY-139385A

  MPEG-2000-DSPE sodium	Inhibitor
  MPEG-2000-DSPE sodium is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. MPEG-2000-DSPE sodium is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents[1][2].

• HY-118421

  Nullscript	Inhibitor
  Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid[1]. Scriptaid is a representative HDAC inhibitor[2]. Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM[3].

• HY-111543

  AN11251	Inhibitor
  AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1].

• HY-19719A

  Miransertib hydrochloride	Inhibitor
  Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib hydrochloride is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research[1]. Miransertib hydrochloride is effective against Leishmania[2].

• HY-W004546

  Abametapir	Inhibitor	99.56%
  Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].

• HY-B0318A

  Metronidazole hydrochloride	Inhibitor
  Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application[1][2][3][4].

• HY-103583

  KDU731	Inhibitor	98.0%
  KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

• HY-12361

  PF 1022A	Inhibitor	99.12%
  PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3].

• HY-N2753

  7-Acetoxybonducellpin C	Inhibitor
  7-Acetoxybonducellpin C, a diterpenoid, is a nature product that could be isolated from the seed kernels of Caesalpinia crista. 7-Acetoxybonducellpin C has antimalarial activity[1].

• HY-B1455S

  Clindamycin-d3 hydrochloride	Inhibitor
  Clindamycin-d3 (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2].

• HY-B2029

  Phosalone	Inhibitor
  Phosalone is a member of the organophosphate family of insecticides.

• HY-19556

  (+)-SJ733	Inhibitor	99.45%
  (+)-SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4.

• HY-135611A

  Imidocarb dihydrochloride monohydrate	Inhibitor
  Imidocarb dihydrochloride monohydrate is a potent antiprotozoal agent. Imidocarb dihydrochloride monohydrate is active against the parasite B. bovis with an IC50 of 87 μg/mL[1].

• HY-126250

  NPD-1335	Inhibitor	98.10%
  NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1].

• HY-14430

  Cipargamin	Inhibitor
  Cipargamin (NITD609) is an potent antimalarial compound, with an IC50 of appr 1 nM against P. falciparum.

• HY-144296

  Purine phosphoribosyltransferase-IN-2	Inhibitor
  Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively[1].

• HY-B1118S1

  Secnidazole-13C2, 15N2	Inhibitor
  Secnidazole-13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.

• HY-19567

  PK 11195	Inhibitor
  PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

• HY-B1455S1

  Clindamycin-13C,d3	Inhibitor
  Clindamycin-13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

• HY-15975

  GNF179	Inhibitor	99.28%
  GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally active[1].

• HY-17532

  Haloxon	Inhibitor
  Haloxon is an anti-parasitic agent. Haloxon can be used for the research of infections of Parascaris equorum, Oxyuris equi and Strongylus vulgaris. Haloxon also can be used in control of ascarids and hookworms in domesticated animals in combination with Bidimazium[1][2].

• HY-122449

  Semduramicin	Inhibitor
  Semduramicin (UK-61689) is an orally active anticoccidial agent with an IC50 value of 30.0 ng/mL for E. tenella. Semduramicin reduces the lesions of E. aceroulina, E. brunetti and E. maxima. Semduramicin (20-30 mg/kg) is well tolerates in broilers and possesses broad spectrum anticoccidial activity. Semduramicin can be used in beef and poultry industry as coccidian inhibitor and growth promoter[1][2][3].

• HY-151942

  Antitrypanosomal agent 10	Inhibitor
  Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.28 μM[1].

• HY-Y0055

  Phenothiazine		99.14%
  Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].

• HY-N0281

  Daphnetin	Inhibitor	99.86%
  Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].

• HY-15980

  GNF179 (Metabolite)	Inhibitor
  GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.

• HY-N5109

  Cheilanthifoline	Inhibitor
  Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC50s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively[1].

• HY-13735B

  Quinacrine hydrochloride hydrate	Inhibitor
  Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis[1].

• HY-B1194

  Tetramisole hydrochloride	Inhibitor	99.79%
  Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic.

• HY-N0381

  Maackiain	Inhibitor	98.03%
  Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a LD50 of  21.95 µg/mL[1]. Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells[2].

• HY-N0176S

  Dihydroartemisinin-d3	Inhibitor
  Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

• HY-122975

  Metronidazole Benzoate	Inhibitor	99.92%
  Metronidazole Benzoate, derives from a metronidazole and a benzoic acid, has a role as an antibacterial, antimicrobial, antiparasitic, and antitrichomonal agent[1].

• HY-151574

  PfGSK3/PfPK6-IN-1	Inhibitor
  PfGSK3/PfPK6-IN-1 (compound 23e) is a potent inhibitor of plasmodial kinases PfGSK3 and PfPK6, with IC50s of 97 nM and 8 nM, respectively. PfGSK3/PfPK6-IN-1 exerts antiplasmodial activity against blood stage Pf3D7 parasites with an EC50 value of 1.4 mM[1].

• HY-N10441

  3β-Hydroxy-hop-22(29)-ene	Inhibitor
  3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana[1].

• HY-B1885

  Fenitrothion	Inhibitor
  Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols[1][2].

• HY-N0193S1

  Artesunate-d4	Inhibitor
  Artesunate-d4 is deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

• HY-12642A

  Diethylcarbamazine	Inhibitor
  Diethylcarbamazine is a microfilaricidal drug used originally in onchocerciasis and lymphatic filiariasis study[1].

• HY-18716

  Dextrorotation nimorazole phosphate ester	Inhibitor
  Dextrorotation nimorazole phosphate ester is an anti-anaerobic and anti-parasitic agent.

• HY-132171

  DSM705	Inhibitor
  DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound[1].

• HY-B0688S1

  Dapsone-d4	Inhibitor
  Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

• HY-145327

  Antimalarial agent 7
  Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum[1].

• HY-108938

  SDZ285428	Inhibitor	98.04%
  SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].

• HY-13836

  ELQ-300	Inhibitor
  ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC50 values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial[1][2].

• HY-136438

  Toltrazuril sulfoxide	Inhibitor
  Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites[1].

• HY-121405

  Malonomicin	Inhibitor
  Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2].

• HY-N0978

  1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	Inhibitor
  1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoid that isolated from the plant of Agrimonia Pilosa with antimalarial and antidiabetic activities[1].

• HY-22044

  ICA	Inhibitor	99.63%
  ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

• HY-B1881

  Pirimiphos-methyl	Inhibitor	98.22%
  Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].

• HY-N10900

  Bruceine C	Inhibitor
  Bruceine C, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine C has anti-Babesial activity[1].

• HY-N0052A

  Sanguinarine chloride	Inhibitor	99.24%
  Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

• HY-12404

  Diminazene aceturate	Inhibitor
  Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].

• HY-B0803S1

  Lumefantrine-d9	Inhibitor
  Lumefantrine-d9 is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

• HY-17599

  Piperazine citrate
  Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist[1]. Piperazine citrate is a vital building block and is an essential core in numerous marketed drugs with diverse pharmacological activities[2].

• HY-136429

  Ethylhydrocupreine	Inhibitor
  Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4].

• HY-135811

  Desethyl chloroquine	Inhibitor
  Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

• HY-B0294S

  Flubendazole-d3	Inhibitor
  Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic drug, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

• HY-129051

  Amoscanate		99.56%
  Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].

• HY-111529A

  Tafenoquine Succinate	Inhibitor	99.98%
  Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].

• HY-148433

  SpdSyn binder-1
  SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria[1].

• HY-103397

  Nanaomycin A	Inhibitor
  Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

• HY-142021

  Z-Leu-Arg-AMC
  Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei[1].

• HY-126417

  Methylenetanshinquinone	Inhibitor
  Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection[1].

• HY-B1186

  Dixanthogen	Inhibitor
  Dixanthogen is an ectoparasiticide.

• HY-146488

  Anti-infective agent 2	Inhibitor
  Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL[1].

• HY-N1458

  Isoschaftoside
  Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles[1][2].

• HY-111746

  CWHM-1008	Inhibitor	99.59%
  CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively[1].

• HY-B2066

  Clofentezine	Inhibitor	98.00%
  Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females.

• HY-125298

  Cycloaspeptide A	Inhibitor
  Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity[1].

• HY-B0846S

  Dimethomorph-d8
  Dimethomorph-d8 is the deuterium labeled Dimethomorph[1]. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM[2][3][4].

• HY-17589S

  Chloroquine-d5 diphosphate	Inhibitor
  Chloroquine-d5 (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

• HY-D0942

  Acridine Orange zinc chloride salt
  Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm)[1][2][3].

• HY-N5107

  Epimagnolin A	Inhibitor	98.12%
  Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells[1].

• HY-B0806AS1

  Proguanil-d6 hydrochloride	Inhibitor	98.73%
  Proguanil-d6 hydrochloride is the deuterium labeled Proguanil hydrochloride (HY-B0806A). Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2][3].

• HY-N8349

  19,20-Epoxycytochalasin D	Inhibitor
  19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity[1].

• HY-N7489

  β-Hederin	Inhibitor
  β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].

• HY-N8513

  Brevicompanine B	Inhibitor
  Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC50 of 35 mg/mL[1].

• HY-B0263S1

  Thiabendazole-13C6	Inhibitor
  Thiabendazole-13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

• HY-101715

  Panidazole	Inhibitor	98.77%
  Panidazole is an amoebicide.

• HY-D0143B

  Quinine hemisulfate hydrate	Inhibitor
  Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV, with an IC50 of 169 μM[1][2].

• HY-N7512

  Asimilobine	Inhibitor
  Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

• HY-B1118

  Secnidazole	Inhibitor	99.88%
  Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

• HY-141836

  MMV666810	Inhibitor
  MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).

• HY-B0827

  Dinotefuran	Inhibitor	98.88%
  Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.

• HY-151935

  Antileishmanial agent-13	Inhibitor
  Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].

• HY-N11550

  Salviandulin E	Inhibitor
  Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 µg/mL[1][2].

• HY-17373

  Posaconazole
  Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.

• HY-151485

  Anti-infective agent 5	Inhibitor
  Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1].

• HY-B0978

  Diethyltoluamide	Inhibitor	99.86%
  Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects.

• HY-135810S

  Cletoquine-d4	Inhibitor
  Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

• HY-N0914

  Ajugol	Inhibitor
  Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC50 of 31.8 μg/mL[1].

• HY-141519

  PI-55	Inhibitor	98.98%
  PI-55 is a specific cytokinin receptor inhibitor. PI-55 is structurally related to 6-benzylaminopurine (BAP) and was shown to inhibit competitively BAP binding on Arabidopsis-specific receptors CRE1/AHK4 and AHK3. PI-55 inhibits cytokinins induced haustorium formation and increased parasite aggressiveness[1].

• HY-19719

  Miransertib	Inhibitor	99.33%
  Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research[1]. Miransertib is effective against Leishmania[2].

• HY-19688B

  Sitamaquine tosylate	Inhibitor
  Sitamaquine (WR 6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1].

• HY-N8385

  19,20-Epoxycytochalasin C	Inhibitor
  19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity[1].

• HY-16762

  Artefenomel	Inhibitor	99.14%
  Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].

• HY-120827

  Allosamidin	Inhibitor
  Allosamidin is an insect chitinase inhibitor with an IC50 of 0.35 μM against Bombyx mori chitinase[1].

• HY-N0110

  Palmatine chloride	Inhibitor	99.49%
  Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].

• HY-117684A

  Cabamiquine succinate	Inhibitor	99.99%
  Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].

• HY-121368

  Mahanine	Inhibitor
  Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection treatment research[1].

• HY-B0825

  (E)-Fenpyroximate	Inhibitor
  (E)-Fenpyroximate is a potent acaricide[1].

• HY-66005S4

  Acetaminophen-13C2,15N
  Acetaminophen-13C2,15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].

• HY-N2656

  5,7,8-Trimethoxycoumarin	Inhibitor
  5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively[1].

• HY-124623

  DNDI-8219	Inhibitor
  DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety[1].

• HY-N10471

  F3226-1387	Inhibitor
  F3226-1387 is a potent Entamoeba histolytica O-acetylserine sulfhydrylase EhOASS3 inhibitor with an IC50 value of 38 μM. F3226-1387 can suppress the growth of the amoeba[1].

• HY-B0887

  Permethrin	Inhibitor
  Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

• HY-N0325

  DL-Methionine	Inhibitor
  DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3].

• HY-W040073S

  Nifurtimox-d4	Inhibitor
  Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

• HY-106662

  Chloroquinoxaline sulfonamide	Inhibitor	99.06%
  Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle[1]. Antitumor activity[2].

• HY-12724A

  Guanabenz hydrochloride	Inhibitor
  Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure[1][2][3].

• HY-12054A

  Hesperadin hydrochloride	Inhibitor
  Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM[1].

• HY-123305S

  5-Hydroxymebendazole-d3
  5-Hydroxymebendazole-d3 is a deuterium labeled 5-Hydroxymebendazole. 5-Hydroxymebendazole is the one metabolite of Benzimidazoles[1].

• HY-13685

  Miltefosine
  Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity[1][2][3][4]. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT)[5].

• HY-17595

  Mebendazole	Inhibitor	99.88%
  Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration[1][2][3].

• HY-N2384

  Febrifugine	Inhibitor	98.75%
  Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

• HY-B0826

  Spirodiclofen	Inhibitor	99.92%
  Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

• HY-12785S

  Albendazole sulfoxide D3	Inhibitor	99.79%
  Albendazole sulfoxide-d3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.

• HY-117025A

  Manzamine A hydrochloride	Inhibitor	99.29%
  Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].

• HY-N0191

  Andrographolide		99.89%
  Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

• HY-B0175

  Toltrazuril	Inhibitor	98.65%
  Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

• HY-79128S1

  Fmoc-L-Lys (Boc)-OH-13C6,15N2	Inhibitor
  Fmoc-L-Lys (Boc)-OH-13C6,15N2 is a 15N-labeled and 13C-labled Triclabendazole.

• HY-146489

  Anti-infective agent 3	Inhibitor
  Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL[1].

• HY-B0827A

  (R)-Dinotefuran	Inhibitor
  (R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, exhibits comparative insecticidal activities (1.7-2.4 times) to typical sucking pests Aphis gossypii and Apolygus lucorum compared to racemic mixtures by inhibiting nicotinic acetylcholine receptors. (R)-Dinotefuran has a good efficacy in controlling target pests while minimizing hazard to honeybees[1].

• HY-N0193

  Artesunate	Inhibitor
  Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

• HY-W049875

  Nitroxynil	Inhibitor	98.84%
  Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica[1][2][3].

• HY-D0008

  Brilliant green	Inhibitor
  Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria[1][2].

• HY-121618

  α-Thujone	Inhibitor
  α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier[1][2][3].

• HY-139854

  DNDI-6148
  DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.

• HY-N8383

  Butyrolactone V
  Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 µg/ml[1].

• HY-W003561

  DHFR-IN-3	Inhibitor	99.64%
  DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively[1].

• HY-B1896S

  Piperaquine-d6
  Piperaquine-d6 is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

• HY-B1359

  Methylene blue trihydrate	Inhibitor
  Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment[1][2][3].

• HY-N7985

  Pendulone	Inhibitor
  Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2].

• HY-B0318S2

  Metronidazole-d3	Inhibitor
  Metronidazole-d3 is deuterium labeled Metronidazole.

• HY-136458

  3-ANOT	Inhibitor
  3-ANOT is a metabolite of Dinitolmide (a nitroamide coccidiostat commonly used in poultry production)[1].

• HY-120060

  GNF6702
  GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis[1].

• HY-A0148A

  Halofantrine hydrochloride	Inhibitor
  Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound[1][2].

• HY-101525

  MBP146-78	Inhibitor	98.47%
  MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.

• HY-114800

  Soporidine
  Soporidine is an antagonist of germination of the parasitic plant Striga hermonthica. Soporidine specifically inhibits a S. hermonthica strigolactone receptor and inhibits the parasite's germination[1].

• HY-N10381

  Zedoalactone B	Inhibitor
  Zedoalactone B is an anti-Babesial agent with an IC50 of 1.6 μg/mL against Babesia gibsoni. Zedoalactone B inhibits NO production with an IC50 of 23.8 μM[1][2].

• HY-13666

  Levamisole hydrochloride	Inhibitor	99.87%
  Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV.

• HY-N9320

  13,21-Dihydroeurycomanone	Inhibitor	98.11%
  13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii[1][2].

• HY-125134

  Alloaromadendrene
  Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans[1].

• HY-N4106

  Dihydroartemisinic acid	Inhibitor	99.08%
  Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin[1].

• HY-120104

  Nitidanin	Inhibitor
  Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection[1][2].

• HY-B1331

  Cyromazine
  Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide.

• HY-B2031S

  Pyriproxyfen-d6
  Pyriproxyfen-d6 is the deuterium labeled Pyriproxyfen[1].

• HY-135858

  SARS-CoV-IN-3	Inhibitor	99.36%
  SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].

• HY-136429A

  Ethylhydrocupreine hydrochloride	Inhibitor	99.83%
  Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4].

• HY-147857

  Antileishmanial agent-12	Inhibitor
  Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 14.9, 21.3 and 9.3 μM, respectively[1].

• HY-U00295

  Melarsonyl	Inhibitor
  Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.

• HY-118427

  Asterriquinol D dimethyl ether	Inhibitor
  Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus[1].

• HY-151433

  Antiparasitic agent-10	Inhibitor
  Antiparasitic agent-10 (Compound 94) is an anti-parasitic agent, shows anti-schistosomal activity. Antiparasitic agent-10 shows activity against adults of Schistosoma mansoni, and can be used in Schistosomiasis research[1].

• HY-10373B

  Trimetrexate isethionate	Inhibitor
  Trimetrexate (CI-898) isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5].

• HY-N1198

  Strictosamide	Inhibitor
  Strictosamide has important effects on inflammation and inflammatory pain. Strictosamide possesses antiplasmodial and antifungal activities[1].

• HY-I1111S2

  Fmoc-L-Val-OH-13C5,15N	Inhibitor
  Fmoc-L-Val-OH-13C5,15N is a 15N-labeled and 13C-labled Pirimicarb. Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an

• HY-B2157

  Robenidine hydrochloride	Inhibitor
  Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.

• HY-18719ES

  Endoxifen-d5	Inhibitor
  Endoxifen-d5 is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].

• HY-112542

  Nemadectin	Inhibitor
  Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity[1].

• HY-18982

  Anisomycin
  Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

• HY-N10697

  Angulatin G	Inhibitor
  Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows LD50 against Mythimna separata of 1656.4 μg/mL[1].

• HY-132170

  DSM502	Inhibitor	99.57%
  DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs[1].

• HY-10373A

  Trimetrexate trihydrochloride	Inhibitor
  Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5].

• HY-147003

  MMV687807	Inhibitor
  MMV687807 is an anthelmintic agent which has a good activity against Toxoplasma gondii (T. gondii) with an IC50 value of 0.15 μM and a CC50 value of 1.69 μM[1].

• HY-B0817

  Pyridaben	Inhibitor	99.55%
  Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[1][2].

• HY-147765

  Anti-Trypanosoma cruzi agent-3	Inhibitor
  Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent[1].

• HY-B0621

  Triclabendazole	Inhibitor	98.72%
  Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.

• HY-N10190

  Asperaculane B	Inhibitor
  Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells[1].

• HY-B0357

  Diclazuril	Inhibitor
  Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al[1][2].

• HY-112435

  UCT943	Inhibitor	98.70%
  UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM[1].

• HY-N6769

  Radicicol
  Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation[1]. Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM[3].

• HY-N10368

  Shinjulactone M	Inhibitor
  Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma[1].

• HY-119766

  Aramite	Inhibitor
  Aramite is a miticide and pesticide[1][2].

• HY-135648

  PfDHODH-IN-1	Inhibitor	99.85%
  PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2].

• HY-B0413

  Fenbendazole	Inhibitor	99.84%
  Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1].

• HY-N0397

  Harpagide	Inhibitor	99.72%
  Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2].

• HY-N10695

  Celangulatin C	Inhibitor
  Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD50 against Mythimna separata of 280.4 μg/mL[1][2].

• HY-113715

  Niclofolan	Inhibitor
  Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].

• HY-W008923

  Doxycycline monohydrate	Inhibitor
  Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor[1][2][3][4].

• HY-B0806AS

  Proguanil-d4 hydrochloride	Inhibitor
  Proguanil-d4 (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].

• HY-N0924A

  (±)-Stylopine hydrochloride		99.66%
  (±)-Stylopine (Tetrahydrocoptisine) hydrochloride is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities[1][2].

• HY-B0273S1

  Sulfadiazine-13C6	Inhibitor
  Sulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide antibiotic with antimalarial activity[1].

• HY-N6615

  Aflatoxin B1		99.94%
  Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation[1][2].

• HY-B1244S

  Dimetridazole-d3	Inhibitor
  Dimetridazole-d3 is a deuterium labeled Dimetridazole. Dmetridazole, a nitroimidazole-based antibiotic, combats protozoan infections[1].

• HY-W040073

  Nifurtimox	Inhibitor	99.65%
  Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

• HY-147536

  Antileishmanial agent-8	Inhibitor
  Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM)[1].

• HY-N3013

  Bruceine B	Inhibitor	99.60%
  Bruceine B inhibits protein synthesis and nucleic acid synthesis[1].

• HY-66004

  4-Acetamidophenyl acetate
  4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic drug, is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2].

• HY-B1414

  Chloroxylenol		99.24%
  Chloroxylenol is a broad spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.

• HY-19285

  Sulfaclozine	Inhibitor
  Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)[1].

• HY-121002

  Alstonine	Inhibitor
  Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1].

• HY-B0840

  Chlorfenapyr		98.48%
  Chlorfenapyr is a pyrrole insecticide. Chlorfenapyr has a mode of action: the mixed function oxidase oxidizes and removes the Nethoxymethyl group to form the active metabolite, CL 303268. Chlorfenapyr is used for termite control and crop protection against a variety of insect and mite pests[1][2].

• HY-B0537B

  Pentamidine isethionate	Inhibitor	99.82%
  Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• HY-B0744C

  L-Eflornithine
  L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1[1].

• HY-B1370B

  (R)-Hydroxychloroquine	Inhibitor
  (R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• HY-N0110B

  Palmatine hydroxide	Inhibitor	99.64%
  Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].

• HY-114489A

  Haemanthamine	Inhibitor
  Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

• HY-B0497S1

  Niclosamide-13C6	Inhibitor
  Niclosamide-13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

• HY-B2028

  Propargite	Inhibitor
  Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC50 of 1 μM[1].

• HY-128204

  AN3661	Inhibitor	99.66%
  AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM), Ugandan field isolates (mean ex vivo IC50=64 nM), and murine P. berghei and P. falciparum infections[1].

• HY-D1200

  Malachite Green Carbinol base	Antagonist
  Malachite Green Carbinol base (MGOH, MGCB) is a derivative of Malachite green (MG) with not fluorescence. Malachite green carbinol base (MGOH, MGCB), as a pH regulation reagent，MGCB molecule could release OH- under UV light irradiation and generate a progressive shift in pH values. MGCB solution turns from colorless to deep green rapidly when exposed to a high-pressure UV lamp (500 W, 50 W/cm)[1][2].

• HY-118448

  2,4-Diacetylphloroglucinol
  2,4-Diacetylphloroglucinol, produced by some isolates of the beneficial bacterium Pseudomonas fluorescens, is a potent antibiotic. 2,4-Diacetylphloroglucinol is active against numerous organisms, including plants, fungi, viruses, bacteria, and nematodes[1].

• HY-N1985

  Acetylastragaloside I	Inhibitor
  Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].

• HY-19502

  Artemisone	Inhibitor
  Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].

• HY-137180

  Naloxonazine
  Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1].

• HY-B0488

  Clorsulon	Inhibitor
  Clorsulon (L631529; MK401) is an orally active flukicidal agent against liver flukes (Fasciola hepatica and Fasciola gigantica) infections in calves and sheep. Clorsulon is also a competitive inhibitor of both 3-phosphoglycorate and ATP andinhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro[1][2].

• HY-133004S

  Fenbutatin oxide-d30	Inhibitor
  Fenbutatin oxide-d30 is the deuterium labeled Fenbutatin oxide. Fenbutatin oxide is an organotin acaricide[1].

• HY-151149

  Trypanothione synthetase-IN-4	Inhibitor
  Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].

• HY-B0497

  Niclosamide	Inhibitor
  Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells[2][3][5].

• HY-117025

  Manzamine A	Inhibitor
  Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1[1][2][3][4].

• HY-N0674A

  Dehydrocorydaline chloride	Inhibitor
  Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

• HY-13582S1

  Carbendazimb-d3
  Carbendazimb-d3 is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

• HY-143487

  Antimalarial agent 12	Inhibitor
  Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli[1].

• HY-119819

  Psicofuranine	Inhibitor
  Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].

• HY-17373A

  Posaconazole hydrate
  Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.

• HY-123561

  MMV008138	Inhibitor	99.48%
  MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM[1][2].

• HY-N2392S

  Kukoamine A-d8 dihydrochloride	Inhibitor
  Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

• HY-118224

  BPH-715	Inhibitor	99.62%
  BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1].

• HY-137445

  Modoflaner	Inhibitor	98.01%
  Modoflaner is an antiparasitic (veterinary use)[1].

• HY-N10534

  Lewis X trisaccharide	Inhibitor
  Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis[1][2][3].

• HY-W019829

  Polyphyllin C	Inhibitor
  Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].

• HY-B1207

  Urethane	Inhibitor
  Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].

• HY-N6707

  Triacsin C	Inhibitor
  Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2].

• HY-B0751

  Fumagillin	Inhibitor
  Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

• HY-B2186

  Piperazine adipate	Inhibitor
  Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.

• HY-B0688S2

  Dapsone-13C12	Inhibitor
  Dapsone-13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5].

• HY-119900

  Carnidazole	Inhibitor
  Carnidazole is an antiprotozoal agent of the nitroimidazole class. Carnidazole is used for the research of Trichomonas infection[1].

• HY-P3425

  AGPV	Inhibitor
  AGPV, a tetrapeptide, has the potential for prevention of schistosome parasite infection research[1].

• HY-12784AS

  Cycloguanil-d4 hydrochloride	Inhibitor
  Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

• HY-15308

  Avermectin B1a	Inhibitor
  Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

• HY-121495

  BKI-1369	Inhibitor	99.71%
  BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1].

• HY-13801

  Fexinidazole	Inhibitor	99.92%
  Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal drug. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei[1].

• HY-N10194

  P-orlandin	Inhibitor
  P-orlandin, a fungal metabolite, prevents FREP1 from binding to gametocytes or ookinetes. P-orlandin effectively inhibits P. falciparum infection in mosquitoes[1].

• HY-B1036

  Decoquinate	Inhibitor
  Decoquinate is a quinolone derivative that can be used for research of coccidiosis in domestic ruminants. Decoquinate also has potent activity against both Plasmodium hepatic development and red cell replication[1][2][3].

• HY-N4044

  Hirsutanonol	Inhibitor
  Hirsutanonol ((5S)-Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae[1].

• HY-135810S1

  Cletoquine-d4-1	Inhibitor
  Cletoquine-d4-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

• HY-147849

  JMI-105	Inhibitor
  JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 µM) and CQR (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].

• HY-B1198

  Piperonyl butoxide	Inhibitor
  Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.

• HY-B0825A

  Fenpyroximate	Inhibitor
  Fenpyroximate is an acaricide and insecticide against many mites and insect pests of agricultural crops and ornamentals. Fenpyroximate is also a strong inhibitor of bovine heart mitochondrial NADH-ubiquinone oxidoreductase (complex I), binds to the ND5 subunit[1][2].

• HY-103353

  SID 26681509	Inhibitor
  SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G[1].

• HY-18719B

  Endoxifen hydrochloride	Inhibitor
  Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].

• HY-132171A

  DSM705 hydrochloride	Inhibitor	99.56%
  DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs[1].

• HY-101476

  Emodepside	Inhibitor	99.28%
  Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.

• HY-W015818

  2-Benzoxazolinone	Inhibitor
  2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4].

• HY-N5029

  Isofebrifugine	Inhibitor
  Isofebrifugine is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect[1].

• HY-A0059

  Nifuratel	Inhibitor	98.87%
  Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).

• HY-B0770

  Artemotil	Inhibitor
  Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys[1][2].

• HY-12642

  Diethylcarbamazine citrate	Inhibitor
  Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements.

• HY-101879

  Acridine Orange hydrochloride		99.86%
  Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm)[1][2][3].

• HY-B0537

  Pentamidine	Inhibitor
  Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• HY-50730

  Asparagusic acid	Inhibitor
  Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor[1][2][3].

• HY-N0325S

  DL-Methionine-13C	Inhibitor
  DL-Methionine-13C is the 13C-labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3].

• HY-100711A

  Prodigiosin hydrochloride	Inhibitor	98.00%
  Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties[1][2].

• HY-N1480S3

  (-)-Fucose-13C-3
  (-)-Fucose-13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

• HY-109987

  ISPA-28	Inhibitor	99.75%
  ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2].

• HY-B1322B

  Amodiaquine dihydrochloride	Inhibitor	99.82%
  Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4][5].

• HY-N5018

  Nepodin	Inhibitor	99.71%
  Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

• HY-103056

  DDD85646		99.62%
  DDD85646 is a potent inhibitor of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nm; hNMTIC50=4 nm). The enzyme N-myristoyltransferase (NMT) is a potential drug target for human African trypanosomiasis[1].

• HY-B0357S

  Diclazuril-d4	Inhibitor
  Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al[1][2].

• HY-107771

  Fluensulfone	Inhibitor	98.75%
  Fluensulfone is a new nematicide for chemical control of plant parasitic nematodes.

• HY-18258

  Berberine chloride
  Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

• HY-N8471

  Niazinin	Inhibitor	99.94%
  Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity[1][2].

• HY-121493

  TM2-115
  TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death[1].

• HY-109077

  Tigolaner
  Tigolaner is a GABA antagonist that regulates chloride channel. Tigolaner is an antiparasitic agent[1].

• HY-U00295A

  Melarsonyl dipotassium	Inhibitor
  Melarsonyl dipotassium (Melarsonic acid dipotassium) is an anthelmintic agent which can inhibit parasite potently[1].

• HY-B0439S

  Sulfadoxine-d4	Inhibitor
  Sulfadoxine-d4 is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

• HY-111529

  Tafenoquine	Inhibitor
  Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].

• HY-B0621S

  Triclabendazole-d3
  Triclabendazole-d3 is the deuterium labeled 4-Methoxybenzylamine[1].

• HY-107814

  Nicarbazin	Inhibitor
  Nicarbazin is an effective anticoccidial agent for chickens[1].

• HY-78131S2

  Ibuprofen-4d
  Ibuprofen-d4 is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[2][3][4][5].

• HY-B1072

  Phenothrin	Inhibitor
  Phenothrin is a synthetic pyrethroid that kills adult fleas and ticks.

• HY-151469

  Chitinase-IN-4	Inhibitor
  Chitinase-IN-4 (compound 8f), an azo-aminopyrimidine derivative, is a potent, selective OfChi-h inhibitor with an IC50 value of 0.1 μM. Chitinase-IN-4 has good insecticidal activity. Chitinase-IN-4 can be used in research of green pest control and management[1].

• HY-N0173

  Cinchonidine	Inhibitor
  Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].

• HY-115249

  Metronidazole acetic acid	Inhibitor	98.18%
  Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa[1][2][3].

• HY-N10401

  Batzelladine D	Inhibitor
  Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC50 of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities[1].

• HY-106338

  Polyketomycin	Inhibitor
  Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

• HY-B0777

  Moxidectin	Inhibitor
  Moxidectin(ProHeart 6; CL301423; Cydectin) is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.

• HY-107814S

  Nicarbazin-d8	Inhibitor
  Nicarbazin-d8 is deuterium labeled Nicarbazin. Nicarbazin is an effective anticoccidial agent for chickens[1].

• HY-B1896A

  Piperaquine phosphate