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  3. Progesterone Receptor

Progesterone Receptor

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.67%
    Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
  • HY-N0437
    Progesterone Agonist 99.46%
    Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-B0469
    Medroxyprogesterone acetate Agonist 99.82%
    Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1]。
  • HY-W011890
    Cridanimod Activator 99.97%
    Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer[1][2].
  • HY-B0257A
    Dydrogesterone Agonist 99.98%
    Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
  • HY-11028
    PF-02413873 Antagonist >99.0%
    PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo[1][2].
  • HY-13676
    Megestrol acetate Inhibitor 99.81%
    Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5].
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[1][2].
  • HY-B0084
    Dienogest Agonist 99.83%
    Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis.
  • HY-15606
    Tanaproget Agonist 99.93%
    Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
  • HY-B0111
    Drospirenone Agonist 98.45%
    Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
  • HY-B0891
    17-Hydroxyprogesterone Agonist 99.94%
    17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.
  • HY-12516
    Desogestrel Agonist 99.70%
    Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).
  • HY-B0648
    Medroxyprogesterone Agonist 99.43%
    Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
  • HY-105634A
    Nomegestrol acetate Agonist 98.50%
    Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1].
  • HY-14959
    Ulipristal Modulator >98.0%
    Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system[1].
  • HY-B0257
    Levonorgestrel Agonist 99.13%
    Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
  • HY-B1095
    Chlormadinone acetate Agonist >98.0%
    Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
  • HY-A0285
    Norethisterone enanthate 99.50%
    Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate is orally active[1][2][3].