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  3. Progesterone Receptor

Progesterone Receptor

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-13683
    Mifepristone Antagonist 98.67%
    Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
  • HY-N0437
    Progesterone Agonist 99.66%
    Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
  • HY-B0469
    Medroxyprogesterone acetate Agonist 99.82%
    Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].
  • HY-W011890
    Cridanimod Activator 99.97%
    Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer[1][2].
  • HY-B0257A
    Dydrogesterone Agonist
    Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
  • HY-12738
    PF-3882845 Antagonist
    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM[1].
  • HY-16508
    Ulipristal acetate Antagonist 99.93%
    Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[1][2].
  • HY-B0084
    Dienogest Agonist 99.83%
    Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis.
  • HY-13676
    Megestrol acetate Inhibitor 99.81%
    Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5].
  • HY-15606
    Tanaproget Agonist 99.93%
    Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
  • HY-B0648
    Medroxyprogesterone Agonist 99.43%
    Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
  • HY-B0891
    17-Hydroxyprogesterone Agonist 99.94%
    17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
  • HY-B0521
    Altrenogest Agonist 99.80%
    Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.
  • HY-B0111
    Drospirenone Agonist
    Drospirenone(Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone.
  • HY-105634A
    Nomegestrol acetate Agonist 98.50%
    Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1].
  • HY-14959
    Ulipristal Modulator
    Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system[1].
  • HY-B0257
    Levonorgestrel Agonist 99.13%
    Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.
  • HY-B1710
    Norethindrone acetate 99.41%
    Norethindrone acetate is a female hormone used for the research of endometriosis[1].
  • HY-12516
    Desogestrel Agonist 99.70%
    Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).
  • HY-B0554
    Norethindrone Agonist
    Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.