1. Membrane Transporter/Ion Channel
  2. Proton Pump

Proton Pump

Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.

Proton Pump Related Products (28):

Cat. No. Product Name Effect Purity
  • HY-100558
    Bafilomycin A1 Inhibitor >99.0%
    Bafilomycin A1 is a macrolide antibiotic isolated from the Streptomyces species and an inhibitor of vacuolar V-ATPase.
  • HY-15295
    TAK-438 Inhibitor 99.97%
    TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.
  • HY-B0113
    Omeprazole Inhibitor
    Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.
  • HY-17507A
    Pantoprazole sodium Inhibitor >98.0%
    Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
  • HY-B0572
    Zinc Pyrithione Inhibitor >98.0%
    Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.
  • HY-13662
    Lansoprazole Inhibitor >98.0%
    Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid.
  • HY-13662B
    (R)-Lansoprazole Inhibitor >98.0%
    (R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid.
  • HY-100007
    TAK-438 free base Inhibitor 99.24%
    TAK-438 (free base) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+ ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.
  • HY-100412
    AZD0865 Inhibitor 98.51%
    AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding.
  • HY-100414
    Soraprazan Inhibitor 99.02%
    Soraprazan is a reversible, and fast-acting inhibitor of gastric H+/K+ ATPase.
  • HY-101664
    Ilaprazole Inhibitor >98.0%
    Ilaprazole (IY-81149) is a proton pump inhibitor; inhibits H+/K+-ATPase with an IC50 of 6.0 μM.
  • HY-B0113S
    Omeprazole D3 Inhibitor >98.0%
    Omeprazole D3 is deuterium labeled Omeprazole, which is a proton pump inhibitor used in the treatment of dyspepsia.
  • HY-B0656A
    Rabeprazole sodium Inhibitor >98.0%
    Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.
  • HY-101427
    Bamaquimast Inhibitor 98.79%
    Bamaquimast is an inhibitor of proton pump extracted from patent US2005165041, example 138.
  • HY-17022
    Esomeprazole Magnesium trihydrate Inhibitor
    Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
  • HY-17023
    Esomeprazole sodium Inhibitor
    Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
  • HY-19223
    Pumaprazole Antagonist
    Pumaprazole is a reversible proton pump antagonist.
  • HY-N2033
    Chebulinic acid Inhibitor
    Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
  • HY-15384
    Picoprazole Inhibitor
    Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.
  • HY-U00042
    SKF96067 Inhibitor
    SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.