1. GPCR/G Protein
  2. Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-19706
    ARS-853 Inhibitor
    ARS-853 is a selective, covalent KRASG12C inhibitor with IC50 of 2.5 μM.
  • HY-15723A
    NSC 23766 trihydrochloride Inhibitor
    NSC 23766 trihydrochloride is a specific inhibitor of the binding and activation of Rac GTPase, used for cancer treatment.
  • HY-14754
    Salirasib Inhibitor
    Salirasib is a potent and competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation.
  • HY-12755
    ML141 Inhibitor
    ML141(CID-2950007) is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase(IC50=200 nM) with low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7).
  • HY-16659
    EHT 1864 Inhibitor
    EHT 1864 is a small molecule inhibitor of Rac1 signaling; modulate γ-Secretase-mediated APP processing.
  • HY-108361
    CCG-203971 Inhibitor
    CCG-203971 is a second-generation RhoA/myocardin-related transcription factor A (MRTF-A) inhibitor. CCG-203971 potently targets RhoA/C-activated serum response element (SRE)-luciferase (IC50=6.2 μM).
  • HY-100270
    Rho-Kinase-IN-1 Inhibitor
    Rho-Kinase-IN-1 is a rho kinase inhibitor extracted from US 20090325960 A1, compound 1.008.
  • HY-U00418
    ARS-1620 Inhibitor
    ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
  • HY-12646
    Rhosin hydrochloride Inhibitor
    Rhosin Hcl is a specific Rho inhibitor; binds to WT RhoA with an affinity ~0.4 uM Kd; does not interfere with the binding of Cdc42 or Rac1.
  • HY-101295
    Pan-RAS-IN-1 Inhibitor
    Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
  • HY-12874
    CASIN Inhibitor
    CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.
  • HY-12810
    EHop-016 Inhibitor
    EHop-016 is a novel potent and selective inhibitor of Rac GTPase; inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 uM.
  • HY-13963
    ZCL278 Inhibitor
    ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
  • HY-13991
    CCG-1423 Inhibitor
    CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis.
  • HY-18707
    K-Ras(G12C) inhibitor 12 Inhibitor
    K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.
  • HY-104064
    1A-116 Inhibitor
    1A-116 is a specific Rac1 inhibitor.
  • HY-12875
    BQU57 Inhibitor
    BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.
  • HY-12649
    Y16 Inhibitor
    Y16 is an inhibitor of G-protein–coupled Rho GEFs; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions.
  • HY-18606
    K-Ras G12C-IN-3 Inhibitor
    K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
  • HY-U00417
    ARS-1630 Inhibitor
    ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.