1. Metabolic Enzyme/Protease
  2. Renin

Renin

Renin is a central hormone in the control of blood pressure and various other physiological functions. Renin is a hormone and an enzyme which chops the end off angiotensinogen, a circulating plasma peptide, thus creating thedecapeptide, angiotensin I. Angiotensin I is acted on by angiotensin converting enzyme (ACE), which chops another bit off to make the octapeptide, angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate the release of aldosterone and aldosterone stimulates Na+ retention.

Renin is rate limiting in the production of angiotensin II (Ang II), a hormone that ultimately integrates cardiovascular and renal function in the control of blood pressure as well as salt and volume homeostasis. For instance, renin seems to be of vast importance for maintaining arterial blood pressure in the face of variations in salt intake: in mice, constant blood pressure is found during alterations in sodium intake, and this relies on controlling the activity of the renin-angiotensin system (RAS).

Renin Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-12177
    Aliskiren hemifumarate Inhibitor 99.47%
    Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-12176
    Aliskiren Inhibitor 99.57%
    Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-50769
    VTP-27999 2,2,2-trifluoroacetate Inhibitor
    VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  • HY-76652
    VTP-27999 Hydrochloride Inhibitor 98.02%
    VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  • HY-50768
    VTP-27999 Inhibitor
    VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
  • HY-12176AS
    Aliskiren D6 Hydrochloride Inhibitor
    Aliskiren D6 Hydrochloride is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM.
  • HY-U00262
    ACT 178882 Inhibitor
    ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.