1. Metabolic Enzyme/Protease
  2. SGK

SGK

Serum- and glucocorticoid-inducible kinase 1 (SGK1) is a member of the Ser/Thr protein kinase family that regulates a variety of cell functions. SGK1 may regulate the cell cycle through the modulation of microtubule (MT) dynamics in tumor cells. SGK1 depolymerizes MTs through two distinct mechanisms both in vitro and in vivo. First, SGK1 directly depolymerizes MT independently of its kinase activity. Second, SGK1 depolymerizes MT through the phosphorylation of tau specifically at Ser214.

SGK1 is under regulation of several hormones, mediators and cell stressors. SGK1 is cloned as a gene up-regulated by serum and glucocorticoids in rat mammary tumor cells.

SGK1 is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na+-reabsorption and accounts for blood pressure increase following high salt diet in mice made hyperinsulinemic by dietary fructose or fat.

SGK Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-15193
    EMD638683 Inhibitor 99.74%
    EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
  • HY-15192
    GSK 650394 Inhibitor 99.38%
    GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively.
  • HY-15193A
    EMD638683 R-Form Inhibitor 99.73%
    EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
  • HY-15193B
    EMD638683 S-Form Inhibitor
    EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.