1. Neuronal Signaling
  2. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor
    Fluoxetine (hydrochloride) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
  • HY-B0492
    Paroxetine hydrochloride Inhibitor
    Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor
    Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • HY-B0176A
    Sertraline hydrochloride Inhibitor
    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B1287
    Citalopram hydrobromide Inhibitor
    Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B0103A
    Fluvoxamine maleate Inhibitor
    Fluvoxamine maleate is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
  • HY-14258A
    Escitalopram oxalate Inhibitor
    Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
  • HY-B1490
    Imipramine hydrochloride Inhibitor
    Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM in vitro.
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor
    Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist
    Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor
    Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
  • HY-14469
    Sibutramine hydrochloride Inhibitor
    Sibutramine hydrochloride is a novel 5-HT (serotonin) and noradrenaline reuptake inhibitor (SNRI). The IC50 for Sibutramine block of voltage-gated K+ channel (KV)4.3 is 17.3 μM.
  • HY-14261
    Vilazodone Hydrochloride Inhibitor
    Vilazodone Hcl (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
  • HY-12850A
    Dasotraline hydrochloride Inhibitor
    Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
  • HY-B0725
    Doxepin Hydrochloride Inhibitor
    Doxepin HCl is a tricyclic antidepressant that is marketed worldwide.
  • HY-B0168B
    Milnacipran (1S-cis) hydrochloride Inhibitor
    Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia.
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor
    Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
  • HY-B0304A
    Dapoxetine hydrochloride Inhibitor
    Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).
  • HY-14262
    Vilazodone Inhibitor
    Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
  • HY-14261S
    Vilazodone D8 Inhibitor
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.