1. Neuronal Signaling
  2. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.86%
    Fluoxetine (hydrochloride) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.84%
    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-14258A
    Escitalopram oxalate Inhibitor >98.0%
    Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.00%
    Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.
  • HY-B1287
    Citalopram hydrobromide Inhibitor 99.71%
    Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine maleate is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.89%
    Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM in vitro.
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 98.25%
    Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.94%
    Vilazodone Hcl (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
  • HY-B0168B
    Milnacipran (1S-cis) hydrochloride Inhibitor 99.96%
    Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia.
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.75%
    Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
  • HY-14469
    Sibutramine hydrochloride Inhibitor >98.0%
    Sibutramine hydrochloride is a novel 5-HT (serotonin) and noradrenaline reuptake inhibitor (SNRI). The IC50 for Sibutramine block of voltage-gated K+ channel (KV)4.3 is 17.3 μM.
  • HY-B0725
    Doxepin Hydrochloride Inhibitor 99.41%
    Doxepin HCl is a tricyclic antidepressant that is marketed worldwide.
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor 99.40%
    Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
  • HY-B0304A
    Dapoxetine hydrochloride Inhibitor 99.85%
    Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).
  • HY-14262
    Vilazodone Inhibitor 99.91%
    Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
  • HY-14261S
    Vilazodone D8 Inhibitor
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.