1. Membrane Transporter/Ion Channel
  2. Sodium Channel

Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.

Sodium Channel Related Products (65):

Cat. No. Product Name Effect Purity
  • HY-12526
    Tetrodotoxin Inhibitor 99.99%
    Tetrodotoxin is a highly selective sodium channel blocker, with IC50 of 33 nM for Nav1.6.
  • HY-B0285A
    Amiloride hydrochloride Inhibitor >98.0%
    Amiloride (hydrochloride) is a relatively selective inhibitor of the epithelial sodium channel (ENaC), used in the management of hypertension and congestive heart failure.
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.85%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2 receptors, 5-HT2A receptors, potassium channel, sodium channel, with Ki of 363 nM and 8.3 nM for dopamine D2 receptor and serotonin 5-HT2A receptor, respectively.
  • HY-12593
    GS967 Inhibitor 99.80%
    GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late INa ) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
  • HY-16738A
    Eleclazine hydrochloride Inhibitor 99.47%
    Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM.
  • HY-B0285B
    Amiloride hydrochloride dihydrate Inhibitor 98.56%
    Amiloride hydrochloride dihydrate is an inhibitor of both Epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA).
  • HY-101840
    EIPA Inhibitor 99.73%
    EIPA is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
  • HY-106150B
    Eniporide hydrochloride Inhibitor 99.31%
    Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor.
  • HY-B0211
    Riluzole Antagonist 99.83%
    Riluzole is a glutamate antagonist used as an anticonvulsant and to prolong the survival of patients with amyotrophic lateral sclerosis.
  • HY-B0246
    Carbamazepine Inhibitor 99.75%
    Carbamazepine, a sodium channel blocker, is an anticonvulsant drug.
  • HY-17429
    Flecainide acetate Inhibitor 99.83%
    Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
  • HY-B0185A
    Lidocaine hydrochloride Inhibitor 99.95%
    Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.
  • HY-B0527A
    Amitriptyline hydrochloride Inhibitor 99.92%
    Amitriptyline Hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).
  • HY-B0575
    Triamterene Inhibitor 99.87%
    Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.
  • HY-B0185
    Lidocaine Inhibitor 99.52%
    Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.
  • HY-B0448A
    Phenytoin sodium Inhibitor 99.50%
    Phenytoin sodium is an inactive voltage-gated sodium channel stabilizer.
  • HY-B0495
    Lamotrigine Inhibitor 99.98%
    Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channel Target: Sodium Channel Lamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1].
  • HY-17401
    Ranolazine dihydrochloride Inhibitor 99.86%
    Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).
  • HY-B0448
    Phenytoin Inhibitor 99.55%
    Phenytoin is an inactive voltage-gated sodium channel stabilizer.
  • HY-12883
    PF 05089771 Inhibitor 98.19%
    PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.