1. Apoptosis
  2. TNF-alpha

TNF-alpha

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine. TNF-alpha can activate the NF-κB pathway by increasing the phosphorylation of IKK-α/β.

TNF-alpha is a negative regulator ofinsulin signal transduction. TNF-alpha is involved in regulating insulin resistance, obesity, as well as fatty acid (FA) and glucose metabolism. It has been confirmed that both adipose tissue and macrophages from activated adipose tissue secret TNF-alpha. The regulatory mechanisms of TNF-alpha on adipose tissue have been fully elucidated in mammals in the past decades. In addition, TNF-alpha is a limiting factor of lipid deposition in some fish species. TNF-alpha participates in regulating fat tissue mass in the gilthead sea bream (Sparusaurata L.), controlling adipose tissue lipid metabolism, and inhibiting the differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchusmykiss). TNF-alpha inhibits the expression of GSK-3β and induces β-catenin expression. TNF-alpha inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), as well as the activity of lipoprotein lipase (LPL) and fatty acid synthetase (FAS). In addition, the level of triglyceride (TG), total cholesterol (TC), nonesterified fatty acid (NEFA), and glycerol is decreased by TNF-alpha treatment in the liver.

TNF-alpha Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor 99.98%
    Lenalidomide is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-10984
    Pomalidomide Inhibitor >99.0%
    Pomalidomide is a known inhibitor of TNF-α release in LPS stimulated human PBMC with IC50 of 13 nM.
  • HY-15615A
    TIC10 Agonist 99.68%
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor 99.82%
    Lenalidomide hemihydrate is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-14622
    Necrostatin 2 Inhibitor 99.89%
    Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
  • HY-N0066
    Eucalyptol Inhibitor >98.0%
    Eucalyptol is an inhibitor of 5-HT3 receptor ,potassium channel, TNF-α and IL-1β.
  • HY-107390
    AX-024 Inhibitor >98.0%
    AX-024 is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
  • HY-N2350
    Cynaropicrin Inhibitor
    Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 99.10%
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-15643A
    LY 303511 hydrochloride Activator 98.41%
    LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.20%
    Cot inhibitor-2 is a COT/Tpl2 inhibitor.
  • HY-100735
    C 87 Inhibitor >98.0%
    C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
  • HY-N0724
    Mesaconitine Inhibitor 99.55%
    Mesaconitine is the main active component of genus aconitum plants.
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor 99.80%
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-A0203
    Pentosan Polysulfate >98.0%
    Pentosan polysulfate is a potent and selective HIV inhibitor.
  • HY-N0182
    Fisetin >98.0%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
  • HY-19717
    DCVC Inhibitor 99.89%
    DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor 98.73%
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-N1949
    Homoplantaginin Inhibitor 99.81%
    Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties.