1. Membrane Transporter/Ion Channel
  2. TRP Channel

TRP Channel

TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Related Products (49):

Cat. No. Product Name Effect Purity
  • HY-17386
    Rosiglitazone Modulator
    Rosiglitazone is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
  • HY-10448
    Capsaicin Agonist
    Capsaicin is a TRPV1 agonist with EC50 of 0.29±0.05 μM in HEK293 cells.
  • HY-15640
    Capsazepine Antagonist
    Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with IC50 of 562 nM.
  • HY-100001
    SKF-96365 hydrochloride Inhibitor
    SKF-96365 hydrochloride, a potent TRP Channel blocker, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.
  • HY-B0545
    Probenecid Agonist
    Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels.
  • HY-112302
    HC-070 Antagonist
    HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.
  • HY-101507
    Pico145 Inhibitor
    Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
  • HY-100965
    Diphenyleneiodonium chloride Activator
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM.
  • HY-15064
    HC-030031 Inhibitor
    HC-030031 is a potent and selective of TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
  • HY-101840
    EIPA Inhibitor
    EIPA is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
  • HY-19608
    GSK1016790A Agonist
    GSK101 (GSK1016790A) is a novel TRPV4 activator.
  • HY-100208
    HC-067047 Antagonist
    HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM).
  • HY-18779
    PF-4840154 Agonist
    PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
  • HY-19975
    RN-1734 Antagonist
    RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).
  • HY-15699A
    SAR7334 hydrochloride Inhibitor
    SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
  • HY-15699
    SAR7334 Inhibitor
    SAR7334 is a potent TRPC6 (Transient receptor potential cation channel, subfamily C, member 6) inhibitor.
  • HY-12245
    SB-366791 Antagonist
    SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM target: VR1/TRPV1 IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08.
  • HY-10634
    AMG 517 Antagonist
    AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
  • HY-11062
    Icilin Agonist
    Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
  • HY-12949
    ML204 Antagonist
    ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.